Endocrine Abstracts

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases characterized by enzyme deficiencies in cortisol secretion. The most common form is 21-alpha hydroxylase deficiency. Here, we report a patient with undertreated CAH and bilateral large adrenal masses.Case report: 34 years old male patient diagnosed with CAH and testicular anorchia at the age of 7 admitted to our clinic for general weakness. Hydrocortisone treatm...

Aim: In this study, we aimed to evaluate the vitamin D and calcium treatments adherence in patients with hypoparathyroidism after surgery.Materials and methods: To elucidate the medication adherence, we performed a questionnaire survey using the six item Morisky Medication Adherence Scale for medication of patients with postoperative hypoparathyroidism. These 6 questions were as follows; 1) Do you sometimes have problems remembering to take your medicati...

Background: Gestational diabetes insipidus (DI) is a rare complication of pregnancy, usually developing in the last trimester and resolves spontaneously 4–6 weeks post-partum. It is mainly caused by excessive vasopressinase activity, an enzyme expressed by placental trophoblasts which metabolises arginine vasopressin (AVP). However in some cases, it can develop in a patient who had limited reserve of ADH and marginal central DI prior to pregnancy and may not reso...

Aim: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer. We also assessed whether the ABO/Rh factor had any effect on prognosis, agressive features and advanced stage of thyroid malignancies.Methods: Medical records of patients who underwent thyroidectomy between December 2006 and September 2014 were evaluated retrospectively. Demographical and clinical features, cytological results (according to Bethesda c...

Introduction: Lithium is the preferred and most efficacious therapy for acute and maintenance therapy of bipolar depressive disorder. Lithium use is associated with an increased incidence of hyperparathyroidism (4.3–6.3%) and have a female preponderance. Bilateral neck exploration was the most common surgical approach while a few patients were managed medically. The initial management of Lithium-associated hyperparathyroidism (LAH) is medical intervention which includes d...

Introduction: Pretibial myxedema is a rare manifestation of Graves’ disease caused by local autoimmune attack of the connective tissue probably mediated by anti TSH receptor autoantibodies (TRab). Its prevalence changes between 0.4 and 5% in Graves ‘patients and usually is accompanied by opthalmopathy. The diagnosis requires physical examination and clinical suspicion and in doubtful cases biopsy may be performed.Case 1: Sixty four years old fe...

Aim: Radioactive iodine (RAI) is one of the treatment approaches in Graves and toxic nodular or multinodular goiter (TNG/TMNG) with low cost and high efficacy. In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine for hyperthyroidism years ago.Methods: Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated...

Introduction: Hepatic dysfunction in hyperthyroidism may occur due to high thyroid hormones, medications or associated autoimmune liver disease. Autoimmune hepatitis or primary biliary cirrhosis (PBC) has rarely been reported in Graves’ disease. We report a patient presenting with pruritus and diagnosed as accompanying PBC and Graves’ disease.Case: A 50 years old female patient applied with progressive pruritus for at least 4 months. Laboratory...

Aim: Multiple endocrine neoplasia-1 (MEN-1) is described in patients as presence of clinical two or more primary MEN-1 associated tumors or patients who have MEN-1 clinics and also have family members with MEN-1 associated tumors. It is associated with loss of activation genetic mutation in a tumor suppressor gene called Menin. MEN-1 is associated with tumors involving the parathyroid glands, anterior hypophysis, and pancreatic islet cells. Primary hyperparathyroidism (PHPT) i...

IntroductionAdrenal abnormalities can be detected incidentally during the imaging performed for malignancies. These abnormalities may include adrenal pathological conditions independent of primary malignancies. Pheochromocytomas detected as part of some familial syndromes are often bilateral.In this report, we present a case of isolated sporadic bilateral pheochromocytoma that was incidentally detected during malignancy workup and staging, which is a rar...