Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep753 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly: a rare disease with multiple, complex complications

Istrate Andra Cristiana , Leustean Letitia , Ungureanu Maria- Christina , Teodoriu Laura , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

ea0090ep1146 | Late Breaking | ECE2023

Normal adult height in a pacient with untreated congenital hypopituitarism: a case report

Bilha Stefana , Popa Viviana , Teodoriu Laura , Christina Ungureanu Maria , Preda Cristina

With congenital hypopituitarism, the clinical manifestations of pituitary hormone deficiencies usually appear during infancy or early childhood. Typically, one or more anterior pituitary hormones are deficient, and the most severe manifestations include neonatal hypoglycemia, electrolyte imbalances and failure to thrive. We present the case of a 43 year old male, with cardiovascular and metabolic comorbidities (arterial hypertension, type 2 diabetes mellitus), with no prior ho...

ea0090ep1169 | Late Breaking | ECE2023

Distant metastasis in a female patient with thyroid and breast carcinoma with low value of Thyroglobulin. Association between thyroid and breast cancer

Teodoriu Laura , Bilha Stefana , Gafton Elena , Leustean Letitia , Ungureanu Maria-Christina , Preda Cristina , Stefanescu Cipriana

Breast cancer (BC) is the most common type of cancer and the leading cause of cancer-related death in women worldwide. A considerable number of these long-term survivors may therefore have an elevated risk of developing a second primary malignancy (SPM). Thyroid cancer (TC) is the most prevalent endocrine malignancy among women. Epidemiologic studies have indicated that patients with BC have a higher risk of developing TC as an SPM, and vice versa, than would be expected in th...

ea0063p1033 | Interdisciplinary Endocrinology 2 | ECE2019

Adipocytokines dynamics in patients operated for rectal neoplasm

Florescu Alexandru , Branisteanu Dumitru , Grigoras Ioana , Bilha Stefana , Dimofte Gabriel , Scripcariu Dragos V

Adipose tissue performs an important endocrine role, mediated by hormones (adipocytokines) which are specifically secreted by the adipocytes. Epidemiological data consistently show an association between weight gain and the risk of colorectal cancer in adults.This observation led to the evaluation of a possible linking role of adipocytokines with cancer pathogenesis. There are several studies that associate adipocytokines with colorectal malignancy, but few data about patients...

ea0037ep1259 | Clinical Cases–Thyroid/Other | ECE2015

Fine needle aspiration biopsy: a method to distinguish between thyroid nodules and parathyroid adenomas

Gatu Alina-Andreea , Velicescu Cristian , Bilha Stefana , Mogos Voichita , Branisteanu Dumitru

Introduction: High-resolution ultrasound (US) allows the location of large parathyroid adenomas. These tumours should be however differentiated from thyroid nodules. For the confirmation of the parathyroid adenoma, we propose US-guided fine-needle aspiration biopsy (FNAB) of suspected nodules, with additional parathyroid hormone (PTH) analysis in the washout of the aspirate (PTH-FNA).Case report: A 51-year old woman with recently installed menopause and ...

ea0037ep1269 | Clinical Cases–Thyroid/Other | ECE2015

The association between Graves' disease and thyroid cancer: coincidence or causality? Case report

Bilha Stefana , Repede Ionut , Gatu Alina , Danila Radu , Velicescu Cristian , Mogos Voichita , Branisteanu Dumitru D

Introduction: Graves’ disease (GD) has been related to a higher incidence of thyroid cancer. Thyroid nodules found in GD seem to have a higher risk for malignancy. The prognosis of thyroid cancer may be aggravated by the association with GD.Case report: We present the case of N.I, a 56-year-old woman diagnosed with multinodular goitre and overt hyperthyroidism for which therapy with carbimazole 40 mg/day was started. She was referred to our Endocrin...

ea0070aep202 | Bone and Calcium | ECE2020

Body composition and adipokines influence upon bone mineral density and bone metabolism in renal transplant receivers

Matei Anca , Bilha Stefana , Constantinescu Daniela , Cianga Petru , Covic Adrian , Branisteanu Dumitru

Introduction: Renal transplant receivers (RTR) have a higher risk for osteoporosis, obesity and sarcopenia, which all seem to be interrelated. FGF23 and adipokine disorders, often recognized in RTR, might be involved in the fat-muscle-bone crosstalk. The current study aims to evaluate the influence of body compartiments and adipokines on bone mass in RTR.Methods: Thiscross-sectional study investigates the predictive role of body composition, adipokines (...

ea0056p173 | Bone ' Osteoporosis | ECE2018

Is FGF23 a key factor in primary hyperparathyroidism?

Gatu Alina-Andreea , Velicescu Cristian , Repede Dan Ionut , Bilha Stefana , Florescu Alexandru , Matei Anca , Branisteanu Dumitru

Published data regarding the role of FGF23 in primary hyperparathyroidism and its prognostic applicability are scarce and discordant.Aims: To assess FGF23 profile in patients with primary hyperparathyroidism undergoing surgery.Matherials and methods: Longitudinal study involving 48 patients aged 30–80 years with primary hyperparathyroidism caused by solitary parathyroid adenoma, submitted to parathyroidectomy. We evaluated FGF...

ea0081p398 | Pituitary and Neuroendocrinology | ECE2022

SARS-CoV-2 infection in acromegaly patients: case series

Bilha Stefana , Matei Anca , Cristiana Istrate Andra , Leustean Letitia , Christina Ungureanu Maria , Branisteanu Dumitru D. , Preda Cristina

Introduction: SARS-Cov-2 infection challenged the appropriate management of acromegaly, because of delayed or limited admissions and treatment. Despite lack of data regarding SARS-Cov-2 infection in acromegalic patients (only one case reported to date), increased susceptibility to infection and poor prognosis might be triggered by the associated metabolic, cardiovascular and respiratory comorbidities. We report a series of acromegaly patients with a positive PCR test at their ...

ea0081ep86 | Adrenal and Cardiovascular Endocrinology | ECE2022

Head and neck paraganglioma: exploring the metastasizing potential. Case report

Teodoriu Laura , Boboc Andreea , Patrascu Ana-Maria , Bilha Stefana , Leustean Letitia , Ungureanu Maria-Christina , Stefanescu Cipriana , Preda Cristina

Introduction: Paragangliomas (PGLs) are tumors originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting.Case report: We present the case of a 60 years old male patient, which was admitte...