Searchable abstracts of presentations at key conferences in endocrinology

ea0014p484 | (1) | ECE2007

Severe hyperandrogenism during the entire course of pregnancy does not cause virilization of a female infant born

Bertalan Rita , Halász Zita , Csabay László , Rigó János , Németh Sándor , Blázovics Anna , Toke Judit , Boyle Belema , Rácz Károly

Objevtives: Maternal hyperandrogenism occurs rarely during pregnancy as the consequense of maternal ovarian or adrenal disorders, or placental aromatase deficiency.Case: A 33-year-old pregnant women was referred because of high serum testosterone (240 ng/dl; normal, 20–60 ng/dl) measured at the 7th week of pregnancy. At presentation she had symptoms of moderate hyperandrogenism, which slightly increased until delivery. Abdominal and pelvic ultrasoun...

ea0073aep384 | Endocrine-Related Cancer | ECE2021

Oncogenic role of splicing factor SRSF2/SC35 in pancreatic and prostate adenocarcinomas

Berbel Inmaculada , Alors-Perez Emilia , Juan M Jiménez-Vacas , Ricardo Blázquez-Encinas , Cristina Viyuela-García , Álvaro Arjona-Sanchez , Juan Manuel Sánchez-Hidalgo , Marina Sánchez-Frías , Enrique Gómez-Gómez , Ortiz Manuel Gahete , Alejandro Ibañez Costa , Luque Raul M. , Justo P. Castaño

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...

ea0073oc9.3 | Oral Communications 9: Endocrine-Related Cancer | ECE2021

Dysregulation of alternative splicing unveils new avenues for targeting pulmonary carcinoids

Blázquez-Encinas Ricardo , Teresa Caro María , García-Vioque Víctor , Pedraza-Arévalo Sergio , Alors-Pérez Emilia , Dulcínea Herrera-Martínez Aura , Sánchez-Sánchez Rafael , Serrano-Blanch Raquel , Foll Matthieu , Fernández-Cuesta Lynnette , D Gahete Manuel , M Luque Raúl , Ibáñez-Costa Alejandro , P Castaño Justo

IntroductionDysregulation of alternative splicing is emerging as a new hallmark of cancer. This dysregulation may originate from mutations and/or altered expression of specific components of the splicing machinery. Indeed, our group has shown that the expression profile of the splicing machinery is altered in several types of cancer, including endocrine-related cancers. However, to date, the status of alternative splicing and its putative dysregulation h...