Searchable abstracts of presentations at key conferences in endocrinology

ea0090p36 | Calcium and Bone | ECE2023

No effects of high-dose vitamin D supplementation on white blood cell count, CRP and risk of upper respiratory tract infections in infertile men – Secondary analyses from a randomized clinical trial

Wall-Gremstrup Gustav , Holt Rune , Juul Anders , Joergensen Niels , Blomberg Jensen Martin

Background: vitamin D has been associated with different beneficial effects on the immune system. The vitamin D activating (CYP2R1 and CYP27B1) and inactivating (CYP24A1) enzymes, including the vitamin D receptor (VDR) are expressed in several types of white blood cells (WBC). A range of studies have explored whether vitamin D positively affects risk of and severity of respiratory tract infections such as tuberculosis, influenza, cold and COVID-19.Object...

ea0090p392 | Endocrine-related Cancer | ECE2023

Influence of CaSR in testicular germ cell tumors

Hjerresen Jasmin , Gobel Nielsen Gustav , Hjorth Andreassen Christine , Juul Anders , Blomberg Jensen Martin

More than 90% of malignant testicular tumors arise in the germ cells and are denoted testicular germ cell tumors (TGCTs). TGCTs are one of the most common cancers among men between 15 to 40 years of age and arise from a common precursor cell, the germ cell neoplasia in situ (GCNIS), an arrested and transformed fetal gonocyte that become invasive after puberty. TGCTs are divided into seminomas and nonseminomas based on histology. Fortunately, TGTCs are highly sensitive to cispl...

ea0032p526 | Endocrine tumours and neoplasia | ECE2013

Expression of FGF23, Klotho, CaSR, and PTHrP in carcinoma in situ and germ cell tumors of the testis: implications for testicular microlithiasis

Blomberg Jensen Martin , Nielsen John E , Jorgensen Anne , Juul Anders , Rajpert-De Meyts Ewa

Introduction: Vitamin D (VD) metabolism is active in normal testis, but lost during the malignant progression from carcinoma in situ (CIS) to overt germ cell tumors (TGCTs). CIS and TGCTs are often associated with intratubular deposition of hydroxyapatite (microlithiasis). Imbalance in FGF23 and PTH homeostasis may result in calcification of mesodermal-derived tissue, so we hypothesized that this mechanism may be involved in testicular microlithiasis. Here, we investi...

ea0090p170 | Reproductive and Developmental Endocrinology | ECE2023

RANKL signalling in female reproduction: a novel role of RANKL outside the skeleton?

Bech Arting Liv , Kooij Ireen , Krarup Knudsen Nadia , Hjorth Andreassen Christine , Juel Mortensen Li , Juul Anders , Blomberg Jensen Martin

Background and Purpose: Infertility affects 15% of couples globally, and only few treatment options are available. Gonadotropins are classic and potent regulators of ovarian and female reproductive function, but novel endocrine crosstalk appears to exist between gonads and the skeleton that may influence female fertility. One of the new players include the RANKL signalling system, which consists of the receptor activator of nuclear factor κβ ligand (RANKL), the recep...

ea0090p180 | Reproductive and Developmental Endocrinology | ECE2023

Vitamin D and IVF/ICSI outcome: Are we measuring the right metabolites?

Kooij Ireen , Gry Kristensen Stine , Bentin-Ley Ursula , Lorenzen Mette , Krog Hans , Juul Anders , Holt Rune , Blomberg Jensen Martin

Background: Numerous studies have suggested that optimal vitamin D status increases treatment success of women undergoing assisted reproductive treatments. However, conflicting data exist, and the relationship remains controversial, prompting the need for more comprehensive studies investigating all the metabolites of vitamin D in women undergoing IVF/ICSI treatment. Objective: To investigate the relationship between follicular fluid levels of the three ...