Endocrine Abstracts

Introduction: There is variation in practice with regards to preoperative optimization protocols and postoperative management in pheocromocytoma and related paraganglioma (PPGL). We aimed to review the literature on perioperative strategies to reduce morbidity and mortality following surgery for PPGL and enhance understanding of optimal approaches.Methods: Two databases were systematically searched in January 2020 for terms related to perioperative manag...

Introduction: Persistent or intermittent postoperative discordance between growth hormone (GH) after OGTT and insulin-like growth factor-1 adjusted for age and gender (IGF-1) is up to 39% according to different studies. The aim of this study was to evaluate the impact of this discrepancy (normal GH and elevated IGF1 or vice versa) over the risk of biochemical and tumour recurrence after initial successful surgery for acromegaly.Methods: In this retrospec...

Background: Silent corticotroph adenomas (SCAs) are considered to be clinically silent and non-secreting but exhibit positive adrenocorticotropic hormone (ACTH) immunostaining. Whether, SCAs behave more aggressively than other non-functioning adenomas, remains controversial. We characterized our tertiary centre cohort of SCA patients, compared them to gonadotroph adenomas (GAs) and assessed for features predictive of recurrence.Objective: To compare char...

Introduction: Pheochromocytoma (PCC) has a wide spectrum of clinical manifestations, from insidious disease to extreme symptoms. Various mechanisms of catecholamine and other mediators actions were related to the diversity of PCC presentation.Aim: We describe a retrospective study, of patients with PCC from a tertiary hospital, focusing on clinical and biochemical characteristics of PCC depending on means of discovery.Material and ...

Introduction: Collision tumors in the thyroid gland are uncommon entities constituting <1% of all thyroid tumors. These are defined as two distinct histological types of tumors arising concurrently within the thyroid, with the combination of Medullary Thyroid Cancer (MCT) and Papillary Thyroid Cancer (PTC) being the most common occurrence. PTC and MTC differ in management strategies and clinical courses, highlighting the importance of accurate diagnosis.<p class="abste...

Objectives: In the last decades, thyroid cancer incidence has increased all over the world. This may be due to heightened medical surveillance and more addressability to surgery, as many cancers are diagnosed while under 1 cm. The aim of our study was to obtain data about the prevalence and histological subtypes of primary thyroid carcinoma in patients undergoing thyroidectomy.Materials and methods: We retrospectively analysed the files of 953 patients w...

Introduction: Long pentraxin 3 (PTX3), a protein cells produce in response to several inflammatory stimuli, is essential in innate immunity, controlling inflammation, tissue remodeling, and cancer dynamics. PTX3 promotes the migration and invasion of cells in different tumor models. This study aims to (I) immunohistochemically assess the presence and distribution of PTX3 in tissue samples from non-medullary thyroid cancer (NMTC) and (II) (TC) to determine the differences of ci...