Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep857 | Thyroid | ECE2020

Association with 3-iodothyronamine improves the effect of levothyroxine on neurocognitive symptoms in a mouse model of adult-onset hypothyroidism

Rutigliano Grazia , Frascarelli Sabina , Borsò Marco , Bandini Lavinia , Zucchi Riccardo

Adult-onset hypothyroidism is related to anxiety, depression, and impaired neurocognition. Guidelines from all professional societies recommend levothyroxine (LT4) monotherapy as the treatment of choice. However, ~15% hypothyroid patients do not achieve a satisfactory functional level despite TSH within the reference range. The beneficial effects of combining LT4 and liothyronine (LT3) to improve neuropsychiatric functions remains unclear. Recently, 3-iodothyronamine (T1A...

ea0070aep858 | Thyroid | ECE2020

3-iodothyronamine ameliorates ischemia-induced synaptic dysfunction in mouse entorhinal cortex

Tozzi Francesca , Rutigliano Grazia , Borsò Marco , Zucchi Riccardo , Origlia Nicola

Abnormalities in thyroid hormone (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer’s disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH metabolism, gained interest for its ability to modulate the nervous and the vascular systems. In the present work, we studied the effect of T1AM on ischemia-induced synaptic dysfunction in the entorhinal cortex (EC), a bra...

ea0070ep418 | Thyroid | ECE2020

3-iodothyronamine (T1AM) is taken up and rapidly metabolized in cell culture medium only at low concentration

Saponaro Federica , Borsò Marco , Verlotta Sara , Bandini Lavinia , Saba Alessandro , Ghelardoni Sandra , Zucchi Riccardo

3-iodothyronamine (T1AM) is rapidly catabolized to iodothyroacetic acid after few hours by serum proteins. To avoid a rapid metabolism during any treatment, DMEM devoid of FBS has been used, inducing changes in the cell culture environmental. We evaluated the uptake and the metabolism of different concentrations of T1AM, in presence of supplemented medium, and the presence of 3-iodothyroacetic aldehyde (Ald), a putative intermediate of T1AM catabolism to TA1.<p ...

ea0014p418 | (1) | ECE2007

The relationship between the increased body mass index and the bone fracture prevalence in postmenopausal pollen allergic women

Ferencz Viktoria , Meszaros Szilvia , Csupor Emoke , Toth Edit , Bors Katalin , Falus Andras , Horvath Csaba

Our aim was to investigate whether pollen-allergy can affect fractures in postmenopausal women. A total of 125 postmenopausal pollen-allergic women (mean age 61.26 yr) were split into four groups: treated neither with H1 histamine receptor (H1R) antagonist nor with inhaled corticosteroid (n=43), treated only with H1R antagonist (n=53), treated both with H1R antagonist and inhaled corticosteroid (n=17), treated only with inhaled corticosteroid (n=12)...

ea0070oc5.1 | Thyroid | ECE2020

TSH-Independent upregulation of thyroid-specific gene expression in dehal1 knockout mice

Alikhani Pouya , Gonzalez-Guerrero Cristian , Liao Xiao-Hui , Borsò Marco , Peluso Teresa , Zucchi Riccardo , Refetoff Samuel , Moreno Jose Carlos

Background: Most thyroid specific genes are transcriptionally regulated by TSH-TSHR signalling and T4-driven negative feedback of TSH secretion at the pituitary. However, local autoregulation of transcription has been described from IGF-IGFR, follicular thyroglobulin, or iodine. We aimed to investigate the TSH dependency of thyroid transcriptional regulation in the Dehal1 knockout, devoid of iodide-recycling capacity from iodotyrosines.Methods: ...