Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1269 | Clinical Cases–Thyroid/Other | ECE2015

The association between Graves' disease and thyroid cancer: coincidence or causality? Case report

Bilha Stefana , Repede Ionut , Gatu Alina , Danila Radu , Velicescu Cristian , Mogos Voichita , Branisteanu Dumitru D

Introduction: Graves’ disease (GD) has been related to a higher incidence of thyroid cancer. Thyroid nodules found in GD seem to have a higher risk for malignancy. The prognosis of thyroid cancer may be aggravated by the association with GD.Case report: We present the case of N.I, a 56-year-old woman diagnosed with multinodular goitre and overt hyperthyroidism for which therapy with carbimazole 40 mg/day was started. She was referred to our Endocrin...

ea0032p88 | Bone and Osteoporosis | ECE2013

Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women

Constantinescu Georgiana , Novac Roxana , Gaspar Ioana , Preda Cristina , Vulpoi Carmen , Mogos Voichita , Branisteanu Dumitru D

Body weight is positively correlated to bone mass. While gravity represents a stimulation stress for bone turnover, endocrine function of adipocytes may also influence bone.Objectives: We investigated the relative influence of weight, body composition and leptin upon lumbar bone mass in pre and postmenopausal women.Materials and methods: Cross-sectional study including six groups varying from 8 to 15 pre- / postmenopausal healthy v...

ea0032p168 | Calcium and Vitamin D metabolism | ECE2013

A clinical case of complicated hyperparathyroidismwith diagnosis delay due to vitamin D deficiency

Novac Roxana , Constantinescu Georgiana , Oprea Andreea , Mogos Voichita , Branisteanu Dumitru D

We present the case of a 75-year-old woman with a 10-year history of nephrolithiasis, for which she endured several sessions of extracorporeal shockwave lithotripsy (ESWL). She was directed to the Endocrinology unit for further investigations, due to persistent albeit minor increased values of blood calcium (10.48 mg/dl, normal 8.4–10.2 mg/dl). Here, the clinical supposition of primary hyperparathyroidism was confirmed. The tests revealed a mild hypercalcemia with hypopho...

ea0016p769 | Thyroid | ECE2008

The influence of chronic GH excess upon thyroid gland morphology evaluated by ultrasound

Buzduga Catalin , Ananie Teodora Emiliana , Mogos Simona , Zbranca Eusebie , Galesanu Corina , Mogos Voichita , Branisteanu Dumitru D

It is known that thyroid pathology is generally more frequently found in women than in men. The somatotroph axis stimulates skeleton growth, but also the development of smooth tissues, including the thyroid gland. We investigated the effect of chronic GH excess upon ultrasound-evaluated (7.5 MHz linear probe) thyroid gland morphology of 74 patients (40 women şi 34 men) diagnosed with acromegaly. When compared to mean thyroid volume of age- and sex-matched non-acromegali...

ea0081p398 | Pituitary and Neuroendocrinology | ECE2022

SARS-CoV-2 infection in acromegaly patients: case series

Bilha Stefana , Matei Anca , Cristiana Istrate Andra , Leustean Letitia , Christina Ungureanu Maria , Branisteanu Dumitru D. , Preda Cristina

Introduction: SARS-Cov-2 infection challenged the appropriate management of acromegaly, because of delayed or limited admissions and treatment. Despite lack of data regarding SARS-Cov-2 infection in acromegalic patients (only one case reported to date), increased susceptibility to infection and poor prognosis might be triggered by the associated metabolic, cardiovascular and respiratory comorbidities. We report a series of acromegaly patients with a positive PCR test at their ...

ea0016p775 | Thyroid | ECE2008

Tuberculosis of the thyroid gland: the chameleon of thyroid pathology

Zbranca Eusebie , Branisteanu Dumitru D , Zbranca Veronica , Pencea Vera , Dobrescu Gioconda , Mogos Voichita , Galesanu Corina , Hurmuzache Stefania , Zbranca Anca

Tuberculous thyroiditis is a very rare disease. Its clinical features are non-specific in most of the cases, mimicking other thyroid diseases. Confusions most frequently made are those with thyroid cancer and toxic nodular goiter. Therefore, diagnosis often comes as a histopathological surprise, after thyroid ablation for other reasons.Thyroid tuberculosis was diagnosed histopathologically in six out of 1232 cases of thyroid surgery. Preoperatory diagnos...

ea0073aep98 | Calcium and Bone | ECE2021

The bone impact of body composition, adipokines and FGF23-Klotho axis in active acromegaly

Bilha Stefana , Matei Anca , Constantinescu Daniela , Pavel-Tanasa Mariana , Mogos-Cioncu Raluca , Cianga Petru , Preda Cristina , Branisteanu Dumitru D.

IntroductionBody composition (BC), adipokines and the fibroblast growth factor-23 (FGF23) - Klotho axis interfere with bone metabolism and also suffer important modifications in acromegaly. We aimed to investigate their influence upon bone in active acromegaly, compared to controls.MethodsWe performed a cross sectional study, investigating the adipokines (leptin, adiponectin, resistin) secretion pattern, BC p...

ea0049ep252 | Calcium & Vitamin D metabolism | ECE2017

The volume of parathyroid adenoma is related to presurgical PTH and 25OH-D3, but not calcium levels at patients with primary hyperparathyroidism

Velicescu Cristian , Gatu Cristina , Grigorovici Alexandru , Danila Radu , Munteanu Valentin , Mogos Voichita , Vulpoi Carmen , Preda Cristina , Mogos Simona , Branisteanu Dumitru D

Aims: We wanted to evaluate the correlations between the volume of the surgically removed parathyroid adenoma and the presurgical metabolic profile of patients diagnosed with primary hyperparathyroidism.Materials and methods: Prospective multicentric study, enrolling 52 patients with primary hyperparathyroidism from two medical units, proposed for surgery. Serum calcium and PTH were evaluated in all patients before surgery, and 25OH-D3 was measured only ...

ea0016p673 | Steroid receptors | ECE2008

Vitamin D receptor gene polymorphism influences the amplitude of 1,25(OH)2D3 immune impact

van Etten Evelyne , Verlinden Lieve , Giulietti Annapaula , Lopez Elizabeth Ramon , Branisteanu Dumitru D , Ferreira Gabriela Bomfim , Overbergh Lutgaard , Verstuyf Annemieke , Bouillon Roger , Roep Bart O , Badenhoop Klaus , Mathieu Chantal

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) influences the differentiation and cytokine secretion of various immune cell types. These immune modulating effects of 1,25(OH)2D3 are mediated through the nuclear vitamin D receptor (VDR). In the immune system, the 1,25(OH)2D3/VDR complex interacts with promoter vitamin D responsive elements (VDRE), or interferes with the signalling of other transcription factor...