Searchable abstracts of presentations at key conferences in endocrinology

ea0063p701 | Pituitary and Neuroendocrinology 2 | ECE2019

Acromegaly in a 29-year-old woman: restored fertility after surgery and radiosurgery

Roque Joao , Reis Dinis , Bugalho Maria Joao

Acromegaly is a rare condition and is frequently associated with infertility. There are very few reported cases of pregnancy in these patients, particularly after surgery and radiosurgery. This is a case of a 29-year-old woman with a 1-year history of nasal obstruction, headache and amenorrhea. She was mother of a 5-year-old child and was trying to get pregnant again, unsuccessfully. Clinical examination revealed coarsening of the facial features, hand and feet enlargement, hy...

ea0056ep70 | Diabetes, Obesity and Metabolism | ECE2018

Controversies of endocrine treatment in Prader-Willi syndrome: a case report of two monozygotic twins

Gomes Vania , Ferreira Florbela , Bugalho Maria Joao

Introduction: Prader-Willi syndrome (PWS) is a neurobehavioral imprinting disorder, which arises due to an absence of paternally expressed genes within the 15q11.2-q13 region. It is the most common syndromic form of obesity, with an estimated prevalence of about 1 in 25,000 individuals.Case report: we report the case of two monozygotic twins, 20-year-old, naturally conceived, both affected by PWS. They were born by eutocic delivery at 34 weeks of gestati...

ea0049ep119 | Clinical case reports - Pituitary/Adrenal | ECE2017

Adrenal haemorrhage: from Urology to Endocrinology

Silvestre Catarina , Gomes Ana , Carvalho Raquel , Bugalho Maria Joao

Background: Bilateral adrenal haemorrhage (Waterhouse–Friderichsen syndrome) is a rare consequence of sepsis (usually a result of meningococcal infection), with an estimated 15% mortality. Despite the predominant association with meningococcal infection, there are other recognised aetiologies: sepsis resulting from other organisms, and non-infectious causes, such as anticoagulant treatment, trauma and postoperative adrenal haemorrhage.Case report: A...

ea0049ep1448 | Thyroid (non-cancer) | ECE2017

Impact of RAC1/1b signalling on Sodium Iodide symporter regulation

Faria Marcia , Matos Paulo , Bugalho Maria Joao , Silva Ana Luisa

The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid cells. Its expression in thyroid tumors allows the use of radioactive iodine (131I) as co-adjuvant therapeutic tool to eliminate remaining tumor cells and metastases after total thyroidectomy. Nevertheless, certain subsets of patients with advanced forms of thyroid cancer lose the ability to respond to radioiodine therapy, which drastically reduces their survival rates. Recent studies ...

ea0056p810 | Pituitary - Clinical | ECE2018

Male hypogonadism – when two endocrine causes merge in the same patient

Araujo Alexandra Novais , Wessling Ana , Bugalho Maria Joao

Introduction: Male hypogonadism is defined by lower levels of testosterone than expected for age-matched individuals. In primary or hypergonadotropic hypogonadism, LH and FSH show a compensatory elevation to low testosterone levels, while in the secondary or hypogonadotropic hypogonadism the low testosterone levels are a result of insufficient gonadotropin levels. Hyperprolactinemia is a cause of hypogonadotropic hypogonadism. It is not only caused by lactotroph adenomas (prol...

ea0081ep752 | Pituitary and Neuroendocrinology | ECE2022

Clinical presentation of non-functioning pituitary tumors: the experience at a tertiary care hospital in Portugal

Ines Alexandre Maria , Gomes Ana , Nobre Ema Lacerda , Marques Pedro , Bugalho Maria Joao

Introduction: Clinically non-functioning pituitary tumors (NFPTs) lack clinical or biochemical evidence of pituitary hormone excess. Their clinical presentation is heterogeneous, including mass effect-related symptoms and/or hypopituitarism, or even no symptoms in incidentally-detected NFPTs. We aimed to evaluate the clinical presentation spectrum of NFPTs in a cohort of patients managed at our hospital.Methods: Clinical, demographic, biochemical and ima...

ea0063p699 | Pituitary and Neuroendocrinology 2 | ECE2019

Hypogonadotropic hypogonadism in a male patient with glycogen storage disease type 1A

Alexandre Maria Ines , Gomes Ana Coelho , Oliveira Anabela , Bugalho Maria Joao

Introduction: The glycogen storage disease (GSD) is a rare disorder of carbohydrate metabolism resulting from the defective synthesis and utilization of glycogen. GSD-1a is a subtype of GSD caused by a deficiency in glucose-6-phosphatase activity, which leads to decreased conversion of glucose-6-phosphate to glucose. The dominant features at presentation are hypoglycemia and lactic acidemia. Long-term complications include blood glucose lability, lactic acidemia, short stature...

ea0049gp226 | Thyroid Cancer | ECE2017

Malignancy Rate in Thyroid Nodules: Cytology versus Histology in challenging categories

Silvestre Catarina , Luis Rita , Bugalho Maria Joao , de Almeida Margarida Mendes , Carvalho Raquel

Background: To stratify the risk of malignancy, thyroid fine-needle aspiration cytology (FNAC) is an important and cost-effective method to evaluate nodules. The Bethesda System for Reporting Thyroid Cytopathology III, IV and V categories are diagnostic challenges, falling between benign and malignant.Objective: Determinate the malignancy rates of thyroid nodules classified as Bethesda Categories III-V.Methods: Retrospective study ...

ea0049gp237 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Thyrotoxic Periodic Paralysis due to Graves’ disease: a mandatory differential diagnosis in Asian patients presenting with paralysis and hypokalemia

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Vilas Ana Paula , Bugalho Maria Joao

Introduction: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of hyperthyroidism that is underdiagnosed and frequently missed. It is relatively common in Asian men with GravesÂ’ disease. TPP attacks are frequently associated with hypokalemia.Case presentation: We describe a 26-year-old Asian male with an unremarkable past medical history who was admitted following sudden onset of flaccid paralysis of the lower extre...

ea0049gp239 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Renal cell carcinoma metastasis to thyroid tumor: a case report

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Subacute thyroiditis (SAT) association with papillary thyroid carcinoma (PTC) has been rarely reported in the literature. Metastatic neoplasms to the thyroid are rare in clinical practice. Renal cell carcinomas (RCC) are the most frequent site of origin of thyroid metastases (12 to 34%). Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. Tuberous sclerosis (TS) is associated with several renal manifestat...