Endocrine Abstracts

Introduction: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. The relationship between apelin serum concentration and dysmetabolic conditions such as type 2 diabetes (T2D) is still controversial. The aim of our study was to investigate the association of apelin with gestational diabetes mellitus (GDM).Design and methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GD...

Purpose: Cocaine and amphetamine-regulated transcript (CART) influences the appetite, obesity and pancreatic functions. The aim of this study is to determine the CART level of patients with PCOS and examine the relation with the insulin resistance in patients with PCOS.Methods: 41 patients with PCOS and and 39 healthy women were included in the study whose age and BMI matched. For PCOS diagnosis, 2003 Rotterdam criteria were used. The fasting serum gluco...

Introduction: Lipocalin-2 is abundantly expressed in mature adipocytes and causes insulin resistance. In the physiopathology of PCOS, insulin resistance has great importance. The purpose of this study was to determine serum lipocalin-2 levels in patients with PCOS and to investigate its relationship with body fat percentage, hs-CRP and insulin resistance.Methods and designs: This study was planned as a case controlled study. We enrolled 44 women with PCO...

Objective: The red blood cell distribution width (RDW) is being recognized as a global marker of chronic inflammation, high level of oxidative stress, and cardiovascular disease risk. We aimed to investigate the relation between the level of RDW and highly sensitive C-reactive protein (hs-CRP), insulin resistance, BMI and body fat percentage in women with polycystic ovary syndrome (PCOS).Methods: Cross-sectional study of 90 PCOS (2003 Rotterdam Consensus...

Context: Irisin is secreted by skeletal muscles into circulation and proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: The aim of this study was to evaluate the effects of acute exercise training (6 week) on circulating plasma irisin in adult mens.Design and setting: This was a cross-sectional study conducted in a university hospital.Participants: A tota...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

Background: This study was planned to reveal the effect of propylthiouracil treatment on CD40, hs-CRP and Fetuin-A levels of subjects with subclinical hyperthyroidism.Material and methods: After checking CD40, hs-CRP and Fetuin-A levels of 35 patients with subclinical hyperthyroidism, they were given 50 mg of propylthiouracil tablet (thrice daily). After the 3-month administration, CD40, hs-CRP and Fetuin-A levels were then compared to the levels before ...

Background: The objective of this trial is to determine pre- and post-levothyroxine treatment levels of inflammation markers, high sensitive-C reactive protein (hs-CRP) and fetuin A in cases with subclinical hypothyroidism.Material and methods: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for hs-CRP ile fetuin A levels, followed by administration of 50 μg levothyroxin...

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Following birth but ...