Endocrine Abstracts

Introduction: In the last few years new imunomodulatory drugs are used for the treatment of metastatic melanoma. One of these drugs is ipilimumab, a monoclonal antibody that activates the immune system by targeting CTLA-4 protein receptor. This monoclonal antibody is very effective but there is a higher risk of endocrinopathies like an adverse effect of treatment, mostly hypophysitis and hypothyroidism.Case: We present a 68-year-old patient with metastat...

Introduction: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder with an estimated prevalence of 1 per 30,000 in the general population. MEN2 is subclassified into two distinct syndromes: types 2A (MEN2A) and 2B (MEN2B). MEN2A and 2B are inherited in an autosomal dominant pattern with very high penetrance. In both syndromes, there is an occurrence of multicentric tumour formation in all organs where the RET proto-oncogene is expressed.<p ...

Introduction: The most common cause of loss of adequate substitution on a stable dose of replacement therapy is noncompliance. Impaired absorption and weight gain are also possible. We present a rare case of renal loss of thyroxin in severe nephritic syndrome.Case report: We present a 46 year old female after total thyroidectomy for Graves-Basedow disease. From 2005 she was euthyroid on a stable dose of L-thyroxin (100 μg/day). On phy...

Introduction: Agranulocytosis represents a serious complication of thyreostatic (ATD) treatment. The aim of our work was to determine how often did agranulocytosis occur in Graves’ disease patients admitted to the thyroid treatment department of our clinic for RAI treatment between the years 1999 and 2014.Patients and methods: We have retrospectively analysed 699 patients (572 women and 127 men at the average age of 51.5±12.9 years). 327 (47%) ...

Introduction: Lymphomas account for <5% of thyroid malignancies. The vast majority of them are non-Hodgkin’s lymphomas (NHL), especially mucosa-associated lymphoid tissue lymphomas (MALT) and diffuse large B-cell lymphomas (DLBCL). However, Hodgkin’s lymphoma affecting thyroid gland is very rare. Worldwide has been reported <50 cases so far and we describe another one.Case report: A 22-year-old woman was referred to our department of en...

Prolactinomas are the most common hormonally active tumours of the pituitary. The treatment of choice is pharmacological. They are treated with cabergolin, which decreases the level of prolactin as well as the size of the tumour. Rarely, dangerous complications can arise after a quick reduction of the tumour’s size.Case presentation: Two men with macroprolactinomas were initially treated with cabergoline (Dostinex®) in a dose of 1 mg per week w...

Lymphocytic hypophysitis is a rare endocrine autoimmune disorder. Principal laboratory markers for diagnosis are antipituitary antibodies (APA). So far there are no standardized methods for the detection of APA and it is not completely clear which antigens are they targeted to as well. At present the indirect immunofluorescence technique is commonly used for their detection. For this purpose cryostat sections of pituitary gland are used. Commercially accessible sections are ac...

We present a family with Von Hippel - Lindau disease (VHL). First two brothers were diagnosed with pheochromocytoma, one of them consecutively in both adrenals in a 16-years’ interval. Then the daughter of one of these two men was diagnosed with pheochromocytoma in both adrenals and one extraadrenal tumour. Later the daughter of the second man was successfully operated for unilateral pheochromocytoma. No neurological signs were present, no other tumours found, and the ocu...

IntroductionPapillary thyroid cancer (PTC) has generally good prognosis irrespective of lymph node metastases. The rate of survival in patients with distant metastases is variable, depending upon the site of metastases and radioiodine accumulation status. The median survival of patients with brain metastases is approximately one year.CaseWe present a 66 years old woman with a tumour triplicity (PTC, breast ca...

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...