Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep302 | Clinical case reports - Pituitary/Adrenal | ECE2016

Hypophysitis as a complication of ipilimumab treatment

Svilias Ioannis , Cap Jan

Introduction: In the last few years new imunomodulatory drugs are used for the treatment of metastatic melanoma. One of these drugs is ipilimumab, a monoclonal antibody that activates the immune system by targeting CTLA-4 protein receptor. This monoclonal antibody is very effective but there is a higher risk of endocrinopathies like an adverse effect of treatment, mostly hypophysitis and hypothyroidism.Case: We present a 68-year-old patient with metastat...

ea0063ep16 | Adrenal and Neuroendocrine Tumours | ECE2019

Multiple endocrine neoplasia typu 2B – case report

Svilias Ioannis , Gabalec Filip , Cap Jan

Introduction: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder with an estimated prevalence of 1 per 30,000 in the general population. MEN2 is subclassified into two distinct syndromes: types 2A (MEN2A) and 2B (MEN2B). MEN2A and 2B are inherited in an autosomal dominant pattern with very high penetrance. In both syndromes, there is an occurrence of multicentric tumour formation in all organs where the RET proto-oncogene is expressed.<p ...

ea0049ep1197 | Clinical case reports - Thyroid/Others | ECE2017

Where is the thyroxin disappearing?

Svilias Ioannis , Gabalec Filip , Cap Jan

Introduction: The most common cause of loss of adequate substitution on a stable dose of replacement therapy is noncompliance. Impaired absorption and weight gain are also possible. We present a rare case of renal loss of thyroxin in severe nephritic syndrome.Case report: We present a 46 year old female after total thyroidectomy for Graves-Basedow disease. From 2005 she was euthyroid on a stable dose of L-thyroxin (100 μg/day). On phy...

ea0041ep1002 | Thyroid (non-cancer) | ECE2016

Occurrence of ATD-induced agranulocytosis and its treatment

Cepkova Jitka , Lasticova Martina , Cap Jan

Introduction: Agranulocytosis represents a serious complication of thyreostatic (ATD) treatment. The aim of our work was to determine how often did agranulocytosis occur in Graves’ disease patients admitted to the thyroid treatment department of our clinic for RAI treatment between the years 1999 and 2014.Patients and methods: We have retrospectively analysed 699 patients (572 women and 127 men at the average age of 51.5±12.9 years). 327 (47%) ...

ea0037ep1088 | Endocrine tumours | ECE2015

Hodgkin's lymphoma presented as goitre: case report

Jakubikova Iva , Cap Jan , Gabalec Filip

Introduction: Lymphomas account for <5% of thyroid malignancies. The vast majority of them are non-Hodgkin’s lymphomas (NHL), especially mucosa-associated lymphoid tissue lymphomas (MALT) and diffuse large B-cell lymphomas (DLBCL). However, Hodgkin’s lymphoma affecting thyroid gland is very rare. Worldwide has been reported <50 cases so far and we describe another one.Case report: A 22-year-old woman was referred to our department of en...

ea0035p932 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Cabergoline-induced pneumocephalus: an unusual complication of macroprolactinoma treatment

Svilias Ioannis , Gabalec Filip , Cap Jan

Prolactinomas are the most common hormonally active tumours of the pituitary. The treatment of choice is pharmacological. They are treated with cabergolin, which decreases the level of prolactin as well as the size of the tumour. Rarely, dangerous complications can arise after a quick reduction of the tumour’s size.Case presentation: Two men with macroprolactinomas were initially treated with cabergoline (Dostinex®) in a dose of 1 mg per week w...

ea0026p240 | Pituitary | ECE2011

Detection of antipituitary antibodies using human and primate pituitary glands in patients with autoimmune thyroid disease and diabetes mellitus type 1

Srbova Libuse , Nikolov Hadzi , Cap Jan

Lymphocytic hypophysitis is a rare endocrine autoimmune disorder. Principal laboratory markers for diagnosis are antipituitary antibodies (APA). So far there are no standardized methods for the detection of APA and it is not completely clear which antigens are they targeted to as well. At present the indirect immunofluorescence technique is commonly used for their detection. For this purpose cryostat sections of pituitary gland are used. Commercially accessible sections are ac...

ea0022p208 | Clinical case reports and clinical practice | ECE2010

A family with Von Hippel - Lindau disease (VHL)

Svilias Ioannis , Cap Jan , Vasatko Tomas

We present a family with Von Hippel - Lindau disease (VHL). First two brothers were diagnosed with pheochromocytoma, one of them consecutively in both adrenals in a 16-years’ interval. Then the daughter of one of these two men was diagnosed with pheochromocytoma in both adrenals and one extraadrenal tumour. Later the daughter of the second man was successfully operated for unilateral pheochromocytoma. No neurological signs were present, no other tumours found, and the ocu...

ea0073ep203 | Thyroid | ECE2021

A rare brain metastases of papillary thyroid cancer

Svilias Ioannis , Cap Jan , Gabalec Filip

IntroductionPapillary thyroid cancer (PTC) has generally good prognosis irrespective of lymph node metastases. The rate of survival in patients with distant metastases is variable, depending upon the site of metastases and radioiodine accumulation status. The median survival of patients with brain metastases is approximately one year.CaseWe present a 66 years old woman with a tumour triplicity (PTC, breast ca...

ea0090ep800 | Pituitary and Neuroendocrinology | ECE2023

Metastatic insulinoma in MEN1 patient

Havlinova Barbora , Soukup Jiri , Hovorkova Eva , Cap Jan

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...