Searchable abstracts of presentations at key conferences in endocrinology

ea0063p410 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Large adrenal incidentalomas require a dedicated diagnostic procedure

Amodru Vincent , Taieb David , Guerin Carole , Paladino Nuncia Cinzia , Brue Thierry , Sebag Frederic , Castinetti Frederic

Introduction: The management of large non secreting adrenal tumors (at least 4 cm) is still a matter of debate as it is unclear whether imaging, especially 18F-FDG, can be used to characterize their potential malignancy. Moreover, the risk of new hypersecretion in non-operated tumors is uncertain. Our aim was to better characterize these large adrenal incidentalomas.Methods: Patients followed in our Center for a non-secreting large (at least 4 cm) adrena...

ea0037s12.3 | Advances in phaeochromocytoma diagnosis and management (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2015

Outcome of adrenal sparing surgery in heritable pheochromocytoma: the example of multiple endocrine neoplasia type 2

Castinetti Frederic

With the early management of medullary thyroid carcinoma, multiple endocrine neoplasia type 2 has become an example of chronic disease with prolonged follow-up to look for pheochromocytoma diagnosis and appropriate management. In any genetic disease where pheochromocytoma can happen bilaterally, the surgery has long been based on bilateral adrenalectomy (even in the presence of a single pheochromocytoma), and as a consequence on a life long treatment for adrenal insufficiency....

ea0032s2.3 | Cushing's Disease with negative pituitary imaging | ECE2013

Medical approach to Cushing’s disease: results of a French multicentre study

Castinetti Frederic

Surgery remains the first line treatment of Cushing’s disease. However, recent studies based on long term follow-up showed that the risk of late recurrence was close to 20–30% cases, whatever the immediate post-surgical cortisol level. In other cases, surgery is not possible due to contra-indications, or refusal by the patient. Medical treatment is thus of major importance in the management of Cushing’s disease, also taking into account the delay to obtain maxim...

ea0026s17.1 | Pituitary update | ECE2011

Radiosurgery and radiotherapy of pituitary adenomas

Castinetti Frederic

Transsphenoidal neurosurgery is the gold standard treatment for pituitary adenomas; however, it can be contra-indicated or ineffective. In these cases, medical treatment based on somatostatin analogs or GH receptor antagonist, can be used. Another approach is to use radiation therapy.Stereotactic radiosurgery (SR) is a procedure aiming at controlling hormone hypersecretion and tumor size of pituitary adenomas. This talk will mainly deal with the long-ter...

ea0090p539 | Late-Breaking | ECE2023

Somatic RET M918T variant can modify the natural history of MEN2 related medullary thyroid carcinoma: a case report and literature review

Sahakian Nicolas , Romanet Pauline , Cinzia Paladino Nunzia , Mirebeau-Prunier Delphine , Castinetti Frederic , Barlier Anne

Background: Multiple endocrine neoplasia type 2 associated medullary thyroid carcinoma (MTC) is driven by a strong genotype-phenotype correlation, the risk of aggressiveness being defined by the germline RET pathogenic variant (American Thyroid Association (ATA) guidelines). Based on this classification, the germline c.2370G>C, p.Leu790Phe (L790F) RET variant is considered to be of moderate risk of aggressive MTC, while the germline c.2753T>C, p.Met918Thr (M9...

ea0035p875 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Pre-surgical medical treatment, a major prognostic factor of remission in acromegaly

Albarel Frederique , Castinetti Frederic , Morange Isabelle , Conte-Devolx Bernard , Guibert Nicolas , Dufour Henry , Brue Thierry

Context: Following the recent evolution in therapeutic strategies for GH-secreting pituitary adenomas, determining optimal individualized patient management is now crucial.Objective: To determine whether pre-surgical medical treatment (PSMT) in patients with acromegaly improves surgical outcome and to specify thresholds for such a strategy.Methods and design: This retrospective study included 110 newly diagnosed acromegalic patient...

ea0022p13 | Adrenal | ECE2010

Pharmacokinetic evidence for hydrococortisone under and over replacement in adrenal insufficiency

Castinetti Frederic , Simon Nicolas , Ouliac Floriane , Lesavre Nathalie , Brue Thierry , Oliver Charles

Aim and methods: Cortisol substitution in adrenal insufficiency (AI) is a matter of debate. We performed a pharmacokinetic analysis of plasma and salivary cortisol following oral hydrocortisone intake in patients with AI, and a pharmacokinetic modelling simulation. Fifty patients with primary (n=20) or secondary (n=30) AI were recruited. After 24-h plasma and salivary cortisol measurements under usual hydrocortisone treatment, a pharmacokinetic modelling with dif...

ea0020p576 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Initial and long-term outcome of surgery in acromegaly: a ten-year, single centre study in 115 patients

Albarel Frederique , Castinetti Frederic , Morange Isabelle , Dubois Noemie , Dufour Henry , Conte-Devolx Bernard , Brue Thierry

Objective: To analyze characteristics of patients who had surgery for a GH-secreting adenoma in the past decade in our centre, to evaluate their initial outcome and long-term recurrence rate using stringent criteria and identify potential predictive factors of surgical remission.Methods: This retrospective study included 115 consecutive patients with acromegaly operated at the neurosurgical department of the Timone Hospital Marseille between 1997 and 200...

ea0073aep844 | Late Breaking | ECE2021

The relative’s viewpoint on acromegaly in remission : A psychosocial dimension of a chronic disease

Fourneaux Rachel , Marie Vermalle , Albarel Frederique , Morange Isabelle , Graillon Thomas , Amodru Vincent , Cuny Thomas , Dufour Henry , Brue Thierry , Castinetti Frederic

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

ea0090oc11.4 | Oral Communications 11: Late Breaking | ECE2023

Persistence of mild hypercortisolism in patients with Cushing’s disease treated with cortisol-lowering drugs : the Haircush study

Manon Fafin , Mohammedi Kamel , Bertherat Jerome , Raverot Gerald , DRUI Delphine , Yves Reznik , Castinetti Frederic , Chanson Philippe , Corentin Rouvray , Amandine Galioot , Brossaud Julie , Tabarin Antoine

Background: Medical treatment with cortisol-lowering drugs is commonly used following pituitary surgical failure or recurrence of hypercortisolism in patients with Cushing’s disease (CD). Studies using late-night salivary cortisol (LNSF) measurement have shown persistent disruption of the circadian secretion of cortisol despite normalization of UFC in a subset of medically treated CD patients. Study aim Our objective was to assess the long-term cortisol exposure in CD pat...