Searchable abstracts of presentations at key conferences in endocrinology

ea0020p673 | Steroid Receptors | ECE2009

Non-classical rapid effects of glucocorticoids on the beta cell function in response to glucose in healthy men

Vila Greisa , Krebs Michael , Baumgartner-Parzer Sabina , Riedl Michaela , Clodi Martin , Pacini Giovanni , Luger Anton

Glucocorticoids suppress insulin secretion, inhibit glucose uptake in peripheral tissues, and promote gluconeogenesis in the liver. These effects are known to be mediated via genomic mechanisms of slow onset. Despite recent evidence on rapid non-genomic glucocorticoid signaling in several organs, there is no information on rapid glucocorticoid effects on carbohydrate metabolism in humans.Here we present data on the rapid effects of hydrocortisone on the ...

ea0016p504 | Obesity | ECE2008

Plasma adrenomedullin positively correlates to body mass index, and significantly decreases after bariatric surgery

Clodi Martin , Vila Greisa , Riedl Michaela , Handisurya Ammon , Maier Christina , Morgenthaler Nils G , Luger Anton

Adrenomedullin is a vasoactive peptide originally discovered in extracts of human pheochromocytoma. It is highly expressed in plasma and adipose tissue of obese subjects and considered as a member of the adipokine family. Adrenomedullin inhibits adipogenesis under the transcriptional control of insulin. We determined plasma adrenomedullin concentrations in a cohort of 360 healthy subjects and found a very significant positive correlation to body mass index (BMI). In parallel, ...

ea0016p506 | Obesity | ECE2008

Cholinergic regulation of meal induced ghrelin and PYY release is impaired in obesity

Maier Christina , Riedl Michaela , Vila Greisa , Wolzt Michael , Clodi Martin , Ludvik Bernhard , Luger Anton

Ghrelin and PYY are gastrointestinal peptides involved in appetite regulation. The cholinergic part of the vagal nerve participate in the regulation of glucose and insulin levels. We aimed to examine the effects of the cholinergic antagonist atropine on ghrelin, PYY, glucose and insulin under basal conditions and after meal ingestion in lean and obese subjects. Eight lean and eight obese subjects received in a randomized, double-blind, placebo controlled crossover study design...

ea0041ep780 | Obesity | ECE2016

Glucose and insulin up-regulate the cardiovascular biomarker GDF15 in vivo and in vitro: effect of meal content and obesity

Schernthaner-Reiter Marie Helene , Kasses Dominik , Tugendsam Christina , Riedl Michaela , Peric Slobodan , Clodi Martin , Luger Anton , Vila Greisa

Introduction: Growth differentiation factor 15 (GDF15) has recently been characterized as a cardiovascular risk factor. GDF15 correlates with insulin resistance and obesity in cross-sectional studies and exerts anorexigenic effects in interventional rodent studies. GDF15 has been proposed as a possible therapeutic target in the treatment of obesity, however its meal- and nutrient-dependent regulation in humans has not been investigated previously.Methods...

ea0022p714 | Obesity | ECE2010

Effects of breastfeeding on maternal appetite-regulating hormones

Vila Greisa , Hopfgartner Judith , Grimm Gabriele , Riedl Michaela , Baumgartner-Parzer Sabina , Kautzky-Willer Alexandra , Clodi Martin , Luger Anton

Gestational weight gain has been linked to obesity in women of childbearing age. Mothers who breastfeed present less postpartum weight retention. The underlying pathophysiological mechanisms are unknown. This study aimed at investigating the impact of breastfeeding on maternal appetite-regulating hormones.The clinical trial recruited 29 women divided in three age- and BMI-matched groups. The first group included 10 fully breastfeeding mothers of 3 to 6 m...

ea0016oc1.9 | Neuroendocrinology and pituitary | ECE2008

Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men

Vila Greisa , Clodi Martin , Geyeregger Rene , Riedl Michaela , Stulnig Thomas M , Struck Joachim , Luger Thomas A , Luger Anton

Oxytocin is a hormone and neurotransmitter with antiinflammatory and neuroimmune-modulatory properties. Physiological states of elevated plasma oxytocin levels are associated with reduced hypothalamic┬ľpituitaty┬ľadrenal response to different stressors. We examined the effect of exogenous oxytocin administration on bacterial endotoxin induced innate immune responses in humans. Ten healthy men received in a randomized, placebo-controlled, cross-over design (1) placebo, ...

ea0016p505 | Obesity | ECE2008

Plasma osteopontin correlates with insulin resistance in obese subjects, but increases following bariatric surgery parallel to other markers of bone turnover

Riedl Michaela , Vila Greisa , Maier Christina , Handisurya Ammon , Shakeri-Manesch Soheila , Prager Gerhard , Wagner Oswald , Kautzky-Willer Alexandra , Clodi Martin , Luger Anton

Osteopontin (OPN) is a multifunctional glycoprotein implicated, among others, in bone metabolism, cardiovascular disease, diabetes and obesity. It promotes inflammation and insulin resistance. Osteopontin is elevated in the plasma and adipose tissue of obese subjects and decreases upon diet induced weight loss. Here we investigated the effect of bariatric surgery on plasma OPN concentrations in morbidly obese patients. 40 obese patients aged 43.1±1.8 years were recruited ...