Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep870 | Clinical case reports - Pituitary/Adrenal | ECE2017

Central diabetes insipidus and cerebral salt wasting syndrome: a challenging coexistence

Costa Maria Manuel , Esteves Cesar , Castedo Jose Luis , Pereira Josue , Carvalho Davide

Introduction: Combined central diabetes insipidus (DI) and cerebral salt wasting syndrome (CSW) is a rare clinical finding. However, when this happens, mortality is high due to delayed diagnosis and/or inadequate treatment.Case report: 42-year-old man referred to neurosurgery due to a non functional pituitary macroadenoma with bitemporal hemianopsia. He underwent partial ressection of the tumour on July 2nd 2015. On the following day of surgery he presen...

ea0049ep871 | Clinical case reports - Pituitary/Adrenal | ECE2017

Adipsic diabetes insipidus – a diagnostic and therapeutic challenge

Magalhaes Daniela , Esteves Cesar , Costa Maria Manuel , Rodrigues Pedro , Carvalho Davide

Introduction: In diabetes insipidus (DI) the serum sodium is often in the high normal range, required to provide the ongoing stimulation of thirst to replace the urinary losses. Marked hypernatremia can occur if a central lesion impairs both ADH release and thirst.Case report: A 57-year-old woman presented with dysuria, polyuria and fever. She was medicated with ciprofloxacin, however, she maintained symptoms, accompanied in the next day by nausea, vomit...

ea0049ep1077 | Pituitary - Clinical | ECE2017

Pituitary apoplexy – presentation, management and outcome in 35 cases

Costa Maria Manuel , Carvalho Bruno , Castedo Jose Luis , Vinha Eduardo , Pereira Josue , Bernardes Irene , Carvalho Davide

Introduction: Pituitary apoplexy is a rare disease which results of haemorrhage and/or infarction of pituitary gland. The optimal management of this problem still remains controversial between surgery and conservative treatment.Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow up of patients with apoplexy. Methods:Retrospective study of 35 pituitary apoplexy followed in a portuguese hospital from 2006 to 2016.<p...

ea0049ep1078 | Pituitary - Clinical | ECE2017

Inferior petrosal sinus sampling: experience of a terciary hospital

Costa Maria Manuel , Castedo Jose Luis , Vinha Eduardo , Pereira Josue , Bernardes Irene , Carvalho Davide

Introduction: Inferior Petrosal Sinus Sampling (IPSS) is the gold standard test to distinguish between Cushing Disease and ectopic ACTH secretion (EAS), mostly when the biochemical tests are discordant and/or there is no lesion in MRI.Aim: To evaluate the results of IPSS in the diagnosis of ACTH-dependent Cushing syndrome.Methods: Retrospective study that analysed IPSS results performed in the last decade in our centre and integrat...

ea0049ep1181 | Male Reproduction | ECE2017

CHARGE syndrome – late diagnosis in adulthood

Costa Maria Manuel , Esteves Cesar , Castedo JoseLuis , Pignatelli Duarte , Carvalho Davide

Introduction: CHARGE syndrome is a rare autossomal dominant genetic disorder with an estimated birth incidence of 1:10000. It affects multiple organ systems and can have a variable phenotypic expression.Case report: 34-years-old man, referred to Endocrinology in the context of bilateral gynecomastia. He had an acute corneal hydrops which was treated by ophthalmology. Physical examination showed short stature (149 cm), obesity (BMI 31.5 kg/m2),...

ea0041ep490 | Diabetes complications | ECE2016

Mauriac syndrome – a rare type 1 diabetes mellitus complication and an opportunity for intervention

Souteiro Pedro , Belo Sandra , Costa Maria Manuel , Carneiro Fatima , Carvalho Davide

Introduction: Mauriac Syndrome is characterized by the presence of hepatomegaly, growth retardation, delayed puberty and cushingoid features. This entity is traditionally diagnosed during the work-up of hepatic enzymes alterations in children/young adults with type 1 diabetes mellitus (T1DM) with poor glycaemic control. However, the impact of metabolic control in the normalization of hepatic analytic profile is not clarified.Methods and design: Retrospec...

ea0037ep1243 | Clinical Cases–Pituitary/Adrenal | ECE2015

Acromegaly caused by atypical pituitary adenoma

Costa Maria Manuel , Saavedra Ana , Castro Ligia , Basto Margarida , Pereira Josue , Vinha Eduardo , Carvalho Davide

Introduction: Atypical pituitary adenomas have higher risk of aggressive behaviour in particular by the higher growth, local invasion and high risk of recurrence after surgery. In acromegaly the resistance to somatostatin analogues may be another manifestation of these adenomas since higher levels of Ki-67 are associated with poor response to therapy.Case report: A 41-year-old woman presented to our consult with history of headaches, growth of the hands,...

ea0035p311 | Clinical case reports Thyroid/Others | ECE2014

A rare case of cutaneous metastization of a differentiated thyroid carcinoma initially diagnosed as Hurthle cell adenoma

Castedo Jose-Luis , Costa Maria Manuel , Pimenta Tiago , Pestana-Silva Roberto , Carvalho Davide

Introduction: Cutaneous metastization of differentiated thyroid carcinomas is a rare event.Clinical case: MMS, a 69-year-old male was submitted to left hemithyroidectomy+isthmectomy on May 2006 after FNA of a left node revealed follicular tumor. Histology showed Hurthle cell adenoma. The patient maintained irregular follow-up by endocrinologist. In October 2011 he referred the appearance of small bilateral cervical skin nodules. Physical exam showed thre...

ea0049gp227 | Thyroid Cancer | ECE2017

Fine needle aspiration biopsy in pediatric patients with thyroid nodules

Costa Maria Manuel , Silva Rita Santos , Castro-Correia Cintia , Sucesso Maria Bom , Coelho Tiago Henriques , Barroca Helena , Fontoura Manuel

Introduction: Although thyroid nodules (TN) are less common in children than in adults, the risk of malignancy is much higher in pediatric age and therefore representing greater concern in this age group.Objective: Evaluate a cohort of pediatric patients with TN and search differences between subjects with malignant and benign TN regarding sex, age, compressive symptoms, cervical ultrasound characteristics, family history of differentiated thyroid cancer...

ea0037ep1224 | Clinical Cases–Pituitary/Adrenal | ECE2015

Cushing's disease in a patient with complicated varicella

Saavedra Ana , Belo Sandra , Costa Maria Manuel , Nogueira Claudia , Freitas Paula , Santos Ana , Santos Lurdes , Carvalho Davide

Introduction: Immunossupression is a possible consequence of hypercortisolism, putting these patients in a state of increased risk of infections.Case report: Female, 19 years old. In July 2014 she seek for medical care because she became feverish and developed an erythematous rash on her face/trunk with subsequent widespread to the entire body. She was admitted in the ICU with the diagnosis of severe varicella with acute cholestatic hepatitis and conflue...