Searchable abstracts of presentations at key conferences in endocrinology

ea0077hdi2.1 | How do I. . .? 2 | SFEBES2021

How do I investigate abnormal alkaline phosphatase?

Crowley Rachel

Alkaline phosphatase is a widely-ordered test from the clinical laboratory. This brief clinical overview will cover the considerations an endocrinologist should make when assessing a patient referred with an incidental finding of either low or elevated alkaline phosphatase. Some discussion from a laboratory perspective will be included, with a clinic visit and the many caveats for interpretation of alkaline phosphatase in mind, as well as the patient f...

ea0037mte9 | (1) | ECE2015

Management of craniopharyngioma

Crowley Rachel

The experience of patients with craniopharyngioma is not benign; these patients are subject to increased mortality compared to age- and gender-matched peers and increased morbidity from hypopituitarism, obesity, thirst and electrolyte disorders and sleep disturbance. This talk will explore the challenges specific to management of this patient cohort, how they differ from other patients with tumoural hypopituitarism, strategies to minimize hypothalamic damage and how to assess ...

ea0013p249 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Sleep disorders in craniopharyngioma patients – a preliminary report

Crowley Rachel , Costello Richard , Thompson Christopher

Objective: Our aim was to identify and treat sleep disorders in asymptomatic patients with craniopharyngioma and to identify co-existing respiratory disease.Methods: 5 patients (1 male) with a diagnosis of craniopharyngioma, were identified from the local pituitary database and admitted for polysomnography (Alice 4, Respironics), as part of a study of hypothalamic disease in craniopharyngioma. Sleep disturbance was defined as an apnoea index (AHI) of &#6...

ea0063p413 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Phenotypic variability within a family with multiple endocrine neoplasia type 1 (MEN1) syndrome

Ahmad Tariq , Sharma Jayant , Crowley Rachel , Kyithar Ma Pyeh

MEN1 is an autosomal dominant endocrine tumour syndrome, caused by inactivating mutations of the MEN1 tumour suppressor gene at 11q13 locus and characterised by occurrence of hyperparathyroidism, pancreatic tumours and pituitary adenomas. We describe a family with MEN1 syndrome. The index case was a 71-year-old man, referred to Endocrinology clinic in Midland Regional Hospital Portlaoise for hypercalcemia (calcium 3 mmol/l, phosphate 0.5 mmol/l, PTH 350 pg/ml, creatin...

ea0037ep738 | Pituitary: clinical | ECE2015

Obstructive sleep apnoea is common in patients who have had surgery for non-functioning pituitary adenomas; preliminary data

Hernandez Martin Cuesta , Crowley Rachel , Costello Richard , Thompson Christopher

Introduction: Some patients complain of excessive daytime somnolence following pituitary surgery.Aim: To investigate the presence of obstructive sleep apnoea (OSA) following surgery for non functioning pituitary adenomas (NFPA).Design and methods: We assessed the prevalence of OSA in 16 routinely selected patients following surgery for NFPA and 13 obese controls attending a tertiary referral centre, by means of the Epworth Sleepine...

ea0037ep1244 | Clinical Cases–Pituitary/Adrenal | ECE2015

Slipped upper femoral epiphysis: a rare clinical manifestation of MEN2: a case report

Slattery Laura , Doherty Jayne , O'Shea Donal , McKenna Malachi , Crowley Rachel

Introduction: Multiple endocrine neoplasia type 2 (MEN2) comprise a group of heritable disorders that result from mutations in the RET proto-oncogene on chromosome 10. MEN2 is sub classified into MEN2A and MEN2B; these syndromes are characterised by the development of tumours at multiple sites. MEN2A is characterised by medullary thyroid cancer, phaeochromocytoma, and primary parathyroid hyperplasia.Description/case presentation: The index case is a 49 y...

ea0034p139 | Clinical practice/governance and case reports | SFEBES2014

Jumping the gun: an audit of adrenal biopsies in a tertiary referral centre

Chortis Vasileios , Scordilis Kassiani , Arlt Wiebke , Crowley Rachel

New adrenal lesions discovered during cross-sectional abdominal imaging pose an increasingly common diagnostic challenge; their initial management should focus on the exclusion of malignancy and autonomous hormone excess. The role of adrenal biopsies in this context is limited and pathologists often struggle to differentiate benign from malignant adrenal tissue even when analysing the entire tumour specimen. Guidelines recommend that adrenal biopsy should only be considered if...

ea0025p80 | Clinical biochemistry | SFEBES2011

Targets for improvement of care for thyroid carcinoma patients in the multidisciplinary setting

Lowney Aoife , Crowley Rachel , O'Halloran Domhnall , Tuthill Antoinette

The British Thyroid Association recommends that a specialist multidisciplinary team (MDT) is responsible for thyroid cancer management. In accordance with this recommendation, a team was formed to manage thyroid carcinoma in a tertiary referral centre. The team included endocrinology, general surgery, ENT, cytology, radiology and radiation oncology consultants.This audit was performed to assess management of thyroid carcinoma before the establishment of ...

ea0021p206 | Endocrine tumours and neoplasia | SFEBES2009

Case report: multiple endocrine neoplasia type 2a and hereditary haemorrhagic telangiectasia presenting consecutively in a single patient

Hussein Omer , Crowley Rachel , Sheahan Patrick , Brady Adrian , Tuthill Antoinette

Multiple endocrine neoplasia type 2a (MEN 2a) is an autosomal dominant disorder with an incidence of ~1 in 30 000 of the population. It is characterized by medullary thyroid cancer (MTC), benign or malignant phaeochromocytomas, and parathyroid hyperplasia or tumours.Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), is also an autosomal dominant disorder; this condition occurs with an incidence of ~1–2 per 100 000 of the population....

ea0074oc9 | Oral Communications | SFENCC2021

Cardiac arrhythmia and ischaemic stroke in a young man with Resistance to Thyroid Hormone beta

Hannon Anne Marie , Kinsella Justin , Crowley Rachel , Moran Carla

Case history: A 42 year old male teacher presented to the emergency department with an acute right MCA infarct, on a background of paroxysmal atrial fibrillation/flutter and recurrent supraventricular tachycardia. He had chronic palpitations, with previous failed cardiac ablation. He had no other medical history, specifically, no history of ear infections or learning difficulties. There was no known family history of thyroid dysfunction. Previous TSH levels (no FT4 measurement...