Searchable abstracts of presentations at key conferences in endocrinology

ea0029p236 | Calcium & Vitamin D metabolism | ICEECE2012

Bone biomarkers, body composition and metabolic profile in patients with primary hyperparathyroidism

Cvijovic G. , Micic D. , Kendereski A. , Zoric S. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

ea0029p436 | Clinical case reports - Thyroid/Others | ICEECE2012

Hypoparathyroidism - a rare cause of heart failure

Zoric S. , Micic D. , Kendereski A. , Cvijovic G. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Introduction: Calcium plays a key role in myocardial contractions and relaxation. Heart failure induced by hypocalcemia is rare but potentially reversible case.Case report: We present the case of 50 years old woman with muscle cramps, cataract, chest pain and dyspnea that lasts 2 years. In regional health center she was treated as psychiatric patient and COPD. Last few months she became extremely malaise with crural edemas and walking distance of 100 m. ...

ea0006p29 | Diabetes, metabolism and cardiovascular | SFE2003


Sumarac-Dumanovic M , Micic D , Mirkovic D , #Dj|#Macut|# , Kendereski A , Zoric S , Cvijovic G , Pejkovic D

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...

ea0004p78 | Reproduction | SFE2002


Macut D , Micic D , Cvijovic G , Sumarac M , Kendereski A , Zarkovic M , Bjekic J , Casanueva F

It is supposed a simillar dirnal change of TSH, free fatty acids (FFA) and leptin in humans. Hypothalamic-pituitary-thyroid axis (HPT) is suppressed during food deprivation while there is an elevation of FFA further influencing glucose metabolism. The aim of our study was to investigate whether leptin can act as a metabolic signal linking the adipose tissue metabolism and the HPT. We studied 13 women with polycystic ovary disease-PCOS (mean age: 26.6±1.83 years; BMI: 34...

ea0029p183 | Bone & Osteoporosis | ICEECE2012

Adiponectin and bone mineral density in obese postmenopausal women

Milin J. , Micic D. , Stamenkovic-Pejkovic D. , Jeremic D. , Kendereski A. , Zoric S. , Cvijovic G. , Sumarac-Dumanovic M.

Introduction: Adiponectin and its receptors are expressed in human osteoblasts, suggesting that adiponectin may be a hormone linking bone and fat metabolism. In contrast to adiponectin anabolic effect on bone in vitro studies, clinical and animal studies suggest that adiponectin may have negative effects on bone by stimulating the receptor activator of nuclear factor-κB ligand (RANKL) pathway and inhibiting the production of the decoy receptor for RANKL and osteopr...

ea0029p1248 | Obesity | ICEECE2012

Association between osteocalcin and insulin resistance in obese women

Sumarac-Dumanovic M. , Milin J. , Stamenkovic-Pejkovic D. , Jeremic D. , Cvijovic G. , Zoric S. , Jorga J. , Micic D.

Introduction: Recent animal’s studies suggest that osteocalcin have influence on beta cell proliferation, insulin secretion and insulin sensitivity. Osteoblasts appear to regulate energy expenditure by acting on adipocytes and pancreatic islet cells via osteocalcin, a 49-residue polypeptide. In turn, adipose tissue may also influence bone remodeling by regulating the activity of osteoblasts through adipokines, including leptin and adiponectin. Some of the complex mechanis...

ea0011p603 | Neuroendocrinology and behaviour | ECE2006

Unrecognized chronic hypopituitarism in patients who survived hemorrhagic fever with renal syndrome

Stojanovic M , Pekic S , Cvijovic G , Kendereski A , Doknic M , Miljic D , Zivkovic V , Djurovic M , Micic D , Popovic V

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease caused by Hantavirus. One of the rare complications of this disease is hypopituitarism (only sporadically reported) due to hemorrhage, necrosis and atrophy of anterior pituitary lobe. The aim of the study was to investigate the anterior pituitary function in patients who recovered from HFRS.We evaluated 31 patients (29 male and 2 female), aged 38.7±2.2 years, with BMI 25.7±0...

ea0029p1255 | Obesity | ICEECE2012

Insulin and C-peptide response after a test meal in obese patients before and 5 days after bariatric gastric by pass surgery

Micic D. , Bajec D. , Polovina S. , Radenkovic D. , Sumarac-Dumanovic M. , Gregoric P. , Cvijovic G. , Ignjatovic S. , Dajak M. , Micic D. , Jeremic D.

Different hypothesis exist about the mechanism of glycose control after bariatric surgery involving intestinal bypass. The aim of our study was to determine the insulin and C-peptide response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric by pass surgery. Glycaemia (mmol/l; glucose oxidase), insulin (ECLIA, Roche Diagnostics, pmol/l) and C-peptide (ECLIA, Roche Diagnostics, pmol/l) were det...

ea0008p20 | Cytokines and growth factors | SFE2004

Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia

Miljic D , Pekic S , Pesko P , Djurovic M , Doknic M , Petakov M , Damjanovic S , Micic D , Cvijovic G , Diguez C , Casanueva FF , Popovic V

Ghrelin is a potent growth hormone (GH) secretagogue in rats and in humans. Since stomach is the main source of circulating ghrelin, gastrectomy reduces plasma ghrelin concentrations by 65%. The implications of decreased circulating ghrelin on GH secretion have not yet been investigated. Furthermore, the neuroendocrine pathways through which ghrelin acts to release GH are largely unknown. We aimed to investigate GH response after insulin induced hypoglycemia (ITT) and after sy...