Endocrine Abstracts

Introduction: Male prolactinomas are very rare pituitary tumors as they account for 1/10 among pituitary tumors secreting prolactin. They are usually larger and more aggressive than female ones. The gonadal deficit due to multi factorial mechanism is well known, but other deficiencies are diversely appreciated. Our aim was to analyze anterior and posterior pituitary functions in a large series of male prolactinomas.Subjects and methods: 117 male prolacti...

Cardiothyreosis (CT) is defined as an association of hyperthyroidism (HT) with severe heart complications such as rhythmic troubles, heart and/or coronary insufficiency. Recently ventricle-auricular block and arterial pulmonary hypertension (APHT) was added to the definition. CT is the most frequent and one of the most dangerous complications of hyperthyroidism (HT) in emerging countries compared to developed countries where this abnormality is deemed to be very rare. Our aim ...

Introduction: Generously supported by IPSEN)-->Epilepsy is a heterogeneous condition with different aetiologies including genetics, cerebral trauma, toxic exposures, infection, vascular diseases and neoplasms. Among the last ones, pituitary tumours (PT) are rarely responsible of convulsions, except when they are very large invading the nervous system. Our aim is to analyze the conditions under which the epilepsy appears and disappear...

Introduction: Suppurative meningitis (SM) is a life threatening disease. It is rarely observed as a primary presentation in large pituitary tumours (PT) destroying the sellar floor and/or invading the skull base. Our aim is to report 3 SM revealing macroprolactinomas.Case No. 1: A man aged 22, consulted for vomiting and fever. The diagnosis of SM was confirmed by lumbar puncture and blood cultures. Cerebral MRI showed multidirectional PT invading caverno...

Introduction: Acromegaly is a relatively rare disease with numerous complications. Our aim is to look for visceral abnormalities and tumour development in subjects with GH and insuIin like GH (or IGF1) excess.Subjets and methods: It is a retro-and prospective study that takes in account 112 patients at diagnosis, with pur pituitary tumours secreting GH, or mixed tumours secreting prolactin and GH diagnosed between 1980 and 2012. They all were questioned ...

Introduction: Generously supported by IPSEN)-->Pituitary tumours are known to cause headaches and visual troubles by compressing pituitary adjacent structures. Pressure on more distant structures is exceptional. In very large tumours such as prolactinomas, mixed adenomas or craniopharyngiomas, hydrocephalus, convulsions, memory troubles and even unconsciousness can be observed, but to our best knowledge motor deficits, such as hemipl...

Introduction: Prolactinomas are more invasive in males. Giant ones (height ≥4 cm) are relatively rare in literature.Our aim is to analyze their frequency, their radiological aspects, and their neurological, endocrine and ophthalmological complications.Methods: All of them had clinical exam, hormonal, ophthalmological, and radiological assessment based on cerebral MRI. Mixed adenomas were excluded. Positive diagnosis was based...

Introduction: Cardiothyreosis is a severe and most frequent heart complication due to hyperthyroidism. It includes severe arrhythmias, heart insufficiency or heart coronary insufficiency ± atrial ventricular block, or pulmonary hypertension.Our aim was to study cardiothyreosis frequency in females, its incidence, its causes, and its response to radical treatment.Subjects and methods: It is a retro-and prospective study which a...

Introduction: Cardiothyreosis (CT) is the most frequent and dangerous complication of hyperthyroidism (HT). It is defined as an association of HT with severe heart abnormalities such: rhythmic troubles, heart and/or coronary insufficiency, atrio-ventricular block, and arterial pulmonary hypertension.Our aim was to study its frequency, in Algerian population, analyze its profile and its response to radical treatment.Materials and me...

Introduction: Glucose metabolism disorders are well known in subjects with GH excess, but little is known about other metabolic abnormalities. Our aim is to analyze metabolic complications in subjects with acromegaly and pituitary gigantism.Subjects and methods: Records of 111 subjects were retrospectively examined, mean GH=62 ng/ml (n<5), mean age=39.11 (14–60). All had routine analysis for fasting blood glucose, cholesterol, triglycer...