Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1426 | Thyroid (non-cancer) | ECE2017

A new strategy to estimate levothyroxine requirement after total thyroidectomy and radioiodine remnant ablation for ‘intermediate’ and ‘high’ risk differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: The approach for initial thyroid hormone suppression in patients who undergo surgery for differentiated thyroid cancer (DTC), is based upon the risk of disease recurrence. In particular, recent American Thyroid Association guidelines suggest to maintain TSH levels between 0.1 and 0.5 mU/l and less than 0.1 mU/l for patients with ‘intermediate’ and ‘high’ risk respectively. The aim of the study is to identify the major predictive factors of LT4...

ea0049ep1341 | Thyroid (non-cancer) | ECE2017

Is Levothyroxine requirement the same for tablet and soft gel formulation in postsurgical hypothyroidism?

Di Donna Vincenzo , Paragliola Rosa Maria , De Waure Chiara , De Rosa Annapina , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: In a previous publication we identified the major predictive factors of levothyroxine (LT4) requirement and proposed an efficient nomogram to calculate LT4 substitutive starting dose after total thyroidectomy for benign disease. The aim of this study was to assess whether the LT4 requirement differs between the tablet and the soft gel capsules formulations.Methods: One hundred and three consecutive patients su...

ea0041gp238 | Thyroid Cancer (1) | ECE2016

Correlation between basal and stimulated thyroglobulin in differentiated thyroid carcinoma of intermediate and high risk

Senes Paola , De Rosa Annapina , Paragliola Rosa Maria , Papi Giampaolo , Locantore Pietro , Pontecorvi Alfredo , Corsello Salvatore Maria

Thyroglobulin (Tg) is a highly sensitive tumor marker of differentiated thyroid cancer (DTC). To optimize the sensitivity, guidelines recommend Tg measurement after stimulation with recombinant TSH (rh-TSH) 6–12 months after radio remnant ablation (RRA). Based on recent evidence in Literature, it is possible to avoid the measurement of Tg after stimulation with rh-TSH (S-Tg) in presence of undetectable values of basal Tg (B-Tg) if high functional sensitivity (0.1 ng/ml) m...

ea0035p1140 | Thyroid Cancer | ECE2014

Thyroglobulin before radio remnant ablation during levothyroxine withdrawal can be considered an accurate parameter of remission of differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Locantore Pietro , Senes Paola , Prete Alessandro , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: Differentiated thyroid cancer (DTC) is the most frequent endocrine cancer. After surgery followed, if any, by 131I radio remnant ablation (RRA), follow-up monitoring consists of neck ultrasonography (US) and measurements of thyroglobulin (Tg) levels and anti-Tg antibodies (Ac-Tg) both on levothyroxine (L-T4) therapy and after recombinant TSH (rTSH). The aim of our study is to define a cut-off of Tg before RRA (RRA-Tg) during <...

ea0020p221 | Endocrine tumours and neoplasia | ECE2009

Severe elevation of testosterone serum levels as unique finding in occult Sertoli-Leydig ovarian cell tumors

Paragliola Rosa Maria , Ricciato Maria Pia , Gallo Francesca , De Rosa Annapina , Senes Paola , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Hirsutism affects 5–10% of women of reproductive age and may be the initial sign of an androgen disorder. We describe two cases of occult Sertoli-Leydig ovarian cell tumor suspected only on the basis of clinical and laboratory features.The first patient, a 42 year-old woman came to our attention for hirsutism. Several blood samples showed a very high testosterone concentration (~4 ng/ml), while non-ovarian causes of hyperandrogenism were excluded. A...

ea0016p793 | Thyroid | ECE2008

Hyperthyroidism associated to hyperthyrotropinemia: differential diagnosis between resistance to thyroid hormone and TSH secreting pituitary adenoma

Paragliola Rosa Maria , Locantore Pietro , Ingraudo Francesca , Gallo Francesca , Ianni Francesca , De Rosa Annapina , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Hyperthyroidism associated to hyperthyrotropinemia is a rare condition which can be due to two different causes: resistance to thyroid hormones and TSH secreting adenoma. The differential diagnosis is not easy.We have observed 8 patients with hyperthyroidism associated to inappropriately elevated TSH. All patients had similar basal levels of thyroid hormones and 7 out of 8 had a multinodular goiter.Four out of 8 patients showed lac...