Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1455 | Thyroid (non-cancer) | ECE2017

Papillary thyroid microcarcinoma: is it worth ablating the patients with radioiodine?

Urhan Muammer , Cagiltay Eylem , Deniz Ferhat

Objective: Recently, radioablation has been offered for patients with thyroid microcarcinoma, however some authors favor just follow-up as the prognosis of this disease is excellent. In this study, we compared the long-term follow-up results, for a period of 16 years, in patients with thyroid microcarcinoma in a group of patients with thyroidectomy only and in another both thyrodectomized and radioablated.Methods: Two hundred sixty five patients with a p...

ea0020p562 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Heart rate variability of young men with hypogonadotropic hypogonadism

Deniz Ferhat , Ermis Necip , Kepez Alper , Kara Batuhan , Omer Azal

Objective: There is little data available regarding the effects of male sex hormones on cardiac autonomic function. The aim of this study is to evaluate the association between male sex steroids and cardiac autonomic function by comparing heart rate variability (HRV) parameters of young male hypogonadotropic hypogonadism patients to those of healthy controls.Design: The study consisted of 22 male hypogonadotropic hypogonadism patients (mean age 20.8&#177...

ea0016p285 | Endocrine tumours | ECE2008

The role of parathyroid hormone-related protein on gynecomatia in patients with Klinefelter's syndrome and idiopathic gynecomastia

Deniz Ferhat , Bolu Erol , Azal Omer , Ozata Metin , Kutlu Mustafa

Background: Parathyroid hormone-related protein (PTHrP) was discovered as a tumor product. It is also one of the complex epithelial and mesenchymal interaction signal mediator in breast development. An increase in the prevalence of malignancy in patients with Klinefelter’s syndrome, but not in patients with idiopathic gynecomastia has been previously reported. PTHrP may play a critical role in the development or progression of breast cancer.Aim: We ...

ea0041ep307 | Clinical case reports - Pituitary/Adrenal | ECE2016

A rare complication of macroprolactinoma treatment with cabergoline: herniation of optic chiasma

Ahmet Ay Seyid , Baskoy Kamil , Ozalper Veysel , Deniz Ferhat , Yonem Arif

Introduction: Prolactinoma is the most common form of all pituitary tumors, and currently, treatment with cabergoline constitutes first choice therapy for prolactinoma. Surgical approach is recommended when medical therapy fails or visual disturbance due to pituitary mass develops. Here we present a case of macroprolactinoma who developed empty sella and optic chiasm protrusion secondary to cabergoline treatment.Case: A 20-year-old male patient referred ...

ea0041ep308 | Clinical case reports - Pituitary/Adrenal | ECE2016

A rare case of panhypopituitarism: pituitary stalk interruption syndrome

Baskoy Kamil , Ahmet Ay Seyid , Basbug Barbaros , Deniz Ferhat , Yonem Arif

Introduction: Hypopituitarism is characterized by decreasing of pituitary hormones, which can result from diseases of the pituitary gland or the hypothalamus. The prevalence of hypopituitarism is 30–45 out of 100 000 in the world wide. Causes of panhypopituitarism are non-tumoral hypotalomopituitary reasons (50%), pituitary tumors (43%) and extra-pituitary tumors (7%). Here we want to present a very rare case of pan hypopituitarism; pituitary stalk interruption syndrome (...

ea0041ep320 | Clinical case reports - Pituitary/Adrenal | ECE2016

A case of Cushing syndrome: long-time before being diagnosed ultimately in despite of abdominoplasty and reduction mammoplasty

Ahmet Ay Seyid , Baskoy Kamil , Ozalper Veysel , Deniz Ferhat , Yonem Arif

Introduction: Cushing’s disease (CD) is rare systemic disease characterized by an endogenous hypercortisolism and it is the most common cause of Cushing’s syndrome (CS). CS is encountered more often in women than in men, associated with an increased morbidity and mortality. Hence, early diagnosis and proper management of the condition is crucial. Here, we present a case of CD, who had abdominoplasty and reduction mammoplasty but went undiagnosed long time with correc...

ea0041ep386 | Clinical case reports - Thyroid/Others | ECE2016

A rare variant of hyperthyroidism: unilateral Graves’ disease

Deniz Ferhat , Baskoy Kamil , Ay Seyid Ahmet , Urhan Muammer , Yonem Arif

Introduction: Despite the fact that Graves’ disease (GD) almost always presents as a diffuse hyperfunctioning goiter involving both lobes of the thyroid gland, it may rarely reveal at only unilateral lobe with bilobar thyroid gland. We herein present a case of unilateral GD involving the right thyroid lobe of a bilobar gland.Case report: A 42-year-old woman presented with symptoms and signs of hyperthyroidism; thyrotropin (TSH) was undetectable, whi...

ea0041ep409 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Functional analysis of G12E mutation of AVPR2 gene in Turkish patients with diabetes insipidus

Erdem Beril , Saglar Emel , Karaduman Tugce , Ozcan Merve , Deniz Ferhat , Mergen Hatice

Diabetes insipidus (DI) is a rare disorder which is characterized with inability to concentrate urine because of severe liquid-balance impairment. Mutations in AVPR2 gene is one of the causes of DI. AVPR2 is a G protein coupled receptor (GPCR) and its specific agonist is arginine vasopressin (AVP). When AVP binds to the AVPR2, which locates on the basolateral side of collecting duct principal cells of the kidney, it triggers accumulation of cAMP in the cell as a seconder messe...

ea0041ep445 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Functional characterization of a large deletion in the AVPR2 gene causing severe nephrogenic diabetes insipidus in a Turkish family

Saglar Emel , Erdem Beril , Karaduman Tugce , Ozcan Merve , Deniz Ferhat , Mergen Hatice

Changes in arginine vazopression type 2 receptor (AVPR2) gene mostly lead to a rare hereditary polyuric disease, X-linked nephrogenic diabetes insipidus (NDI). The disease is characterized by the production of large amounts of urine and an inability to concentrate urine in response to the antidiuretic hormone vasopressin. In our previous study we have identified a novel 388 bp deletion in the AVPR2 gene in a patient with NDI and in his family. For fu...

ea0037ep1329 | Clinical Cases–Thyroid/Other | ECE2015

Functional analysis of four mutants of the V2 receptor

Erdem Beril , Schulz Angela , Saglar Emel , Schoneberg Torsten , Deniz Ferhat , Mergen Hatice

Diabetes insipidus is a disorder characterised by severe liquid-imbalance because of the inability to concentrate urine. Inactivating mutations in either arginine vasopressin receptor type 2 (AVPR2) or aquaporin 2 (AQP2) gene can cause congenital Nephrogenic diabetes insipidus (NDI). AVPR2 is a G protein-coupled receptor (GPCR) and is mainly expressed at the basolateral site of the kidneys collecting duct principal cells. Activation of this receptor by vasopressin is responsib...