Searchable abstracts of presentations at key conferences in endocrinology

ea0037s1.2 | Glucocorticoid action in health and disease | ECE2015

Subclinical Cushing's syndrome and cardiovascular disease

Dalmazi Guido Di

Subclinical Cushing’s syndrome, defined as evidence of alterations of the HPA axis in patients without stigmata of hypercortisolism, is a frequent finding among patients with adrenal incidentalomas. It is well-known that this condition is associated with several co-morbidities, such as hypertension in 2/3 of the cases, diabetes in 1/3, and dyslipidemia, which impair the cardiovascular risk profile of those patients. Recently, different independent reports on the natural h...

ea0029s35.1 | Endocrinology and the Olympics: Will hormones help to win? | ICEECE2012

Does the high performance athlete need hormone replacement?

Di Luigi L.

Endogenous hormones (e.g. catecholamines, glucocorticoids, growth hormones, androgens, growth factors) may affect the characteristics of physical capacity and performance in athletes by influencing, throughout long-term and short term effects, morphological and functional qualities of neuromuscular, cardiovascular, metabolic and adaptive systems. Exercise per se is associated to the release of different hormones: acute exercise stimulates an acute hormones secretion (e.g. cate...

ea0011p4 | Bone | ECE2006

Clinical aspects of diabetic osteoarthropathy in type 1 and type 2 diabetes mellitus patients

Shepelkevich AP , Romeiko DI

Aims: The clinical and radiological observation of patients with diabetic osteoarthropathy (DOAP) was carried out with the aim of determining the most significant factors in type 1 and type 2 diabetes mellitus (DM) patients.Methods and materials: Anamnesis, clinical and radiological data were analsed in 28 DOAP patients. The patients were divided into two groups according to the type of diabetes: group 1 included 14 patients with type 1 DM (mean age 37.8...

ea0003s4 | British Thyroid Association - Pitt-Rivers Lecture | BES2002

Molecular genetics of congential hypothyroidism

Di|#Lauro R

Congenital hypothyroidism (CH) is one of the most frequent congenital diseases. In 85% of cases, this condition is due to thyroid dysgenesis (TD) whose phenotype - thyroid absent or ectopically located and/or severely reduced in size - clearly represent disturbances during gland organogenesis. Some years ago we discovered that three transcription factors, TTF-1, TTF-2 and Pax-8, are expressed not only in mature thyroid cells but also in their precursors. Work in animal models ...

ea0003s4biog | British Thyroid Association - Pitt-Rivers Lecture | BES2002

British Thyroid Association - Pitt-Rivers Lecture

Di Lauro R

Roberto Di Lauro, School of Medicine of the University of Naples 'Federico II', Naples, Italy AbstractRoberto Di Lauro is Professor of Human Genetics at the School of Medicine of the University of Naples 'Federico II'. He is also responsible for the Laboratory of Biochemistry and Molecular Biology at the Stazione Zoologica 'Anton Dohrn' (Naples). He was visiting associate from 1974 to 1978 and visiting scientist from 1...

ea0073js3.2 | ESE/Endocrine Society Joint Session: Emerging endocrine abnormalities and COVID-19 outcomes | ECE2021

Fractures

di Filippo Luigi

Osteoporotic fractures are the main clinical manifestations of skeletal fragility and are associated with decreased survival and impaired quality of life in the general population. At the beginning of COVID-19 spread in Europe, despite several studies investigated COVID-19 clinical characteristics, no data were reported on the prevalence of vertebral fractures (VFs) in patients affected and disease impact on osteoporotic patients. We performed a retrospective study at San Raff...

ea0049ep1171 | Male Reproduction | ECE2017

Male pseudohermaphroditism with 45,X/46,X,idic(Y) karyotype: a case presenting with dysgenetic testis on one side and almost normally sized testis on the other side

Di Bari Flavia , Vita Roberto , Benvenga Salvatore

: Dicentric Y chromosome [idic(Y)] is the most common structural abnormality of this chromosome, and generally results from altered meiotic breakage and reunion of sister chromatids. Since this rearrangement is unstable, idic(Y) may be lost in subsequent cell cycles, resulting in a mosaic 45,X cell line. Variable are the phenotype and gonads (from streak gonads to ovotestes or dysgenetic testes). Few cases of 45,X/46,X,idic(Y) male pseudohermaphroditism with testes have been r...

ea0025cm2.2 | Endocrine problems in pregnancy | SFEBES2011

Treatment of hyperthyroidism in pregnancy: risk for the unborn

Clementi Maurizio , Cassina Matteo , Di Gianantonio Elena

Clinical hyperthyroidism is not uncommon in pregnancy, with a reported prevalence of 0.1–0.4%, and is caused most frequently by Graves disease. Careful monitoring of thyroid function is critical in preventing the many potential complications that can occur in pregnancies of mothers with hyperthyroidism. Maternal complications include hypertension, thyroid storm, heart failure preterm labour, and placental abruption. Foetal and neonatal complications include stillbirth, in...

ea0029p305 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Lipid profile in children with persistent idiopathic subclinical hypothyroidism

De Martino L. , Cerbone M. , Barbieri F. , Esposito A. , Di Donato I. , Di Mase R. , Salerno M.

Background: There is a great controversy on whether subclinical hypothyroidism (SH) in children should be treated for TSH values between 4.5 and 10 mU/l. In adults SH has been associated with abnormalities in lipid profile and increased risk of atherosclerosis. Data in untreated SH children are scanty.Objective: The aim of this cross-sectional controlled study was to evaluate in children the effects of long term untreated SH on lipid profile and endothel...

ea0029p309 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Risk factors of metabolic syndrome in adolescent with classical congenital adrenal hyperplasia

Esposito A. , De Martino L. , Improda N. , Capalbo D. , Di Mase R. , Di Donato I. , Salerno M.

Background: Patients with classical congenital adrenal hyperplasia (CAH) require life-long therapy with glucocorticoids in order to suppress the androgen production through the inhibition of CRH and consequently ACTH. The therapy must be balanced to avoid either iatrogen hypercortisolism or hyperandrogenism both potentially associated with adverse cardiovascular risk profile.Objective: Aim of this cross-sectional controlled study was to investigate the m...