Searchable abstracts of presentations at key conferences in endocrinology

ea0044p185 | Obesity and Metabolism | SFEBES2016

A retrospective study assessing the effects of OSA in women with PCOS attending the weight management clinic

Kahal Hassan , Dimitriadis George K. , Kyrou Ioannis , Ali Asad , Tahrani Abd A , Randeva Harpal

Introduction: Obstructive Sleep Apnoea (OSA) is more common in women with Polycystic Ovary Syndrome (PCOS). There is paucity of data regarding the impact of OSA in women with PCOS.Methods: We conducted a retrospective study using electronic patients’ records of premenopausal women with PCOS who were first seen in the weight management clinic (WMC) between March/2008 and November/2014. PCOS diagnosis was documented either by referring clinician or es...

ea0041ep822 | Obesity | ECE2016

Visceral adiposity index as a marker of hepatic steatosis in overweight and obese premenopausal women

Vassilatou Evangeline , Vassiliadi Dimitra , Lazaridou Helen , Koutsomitopoulos Nikitas , Kelekis Nikolaos , Hadjidakis Dimitrios , Dimitriadis George

Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopau...

ea0037ep303 | Calcium and Vitamin D metabolism | ECE2015

Fragility fractures as the initial manifestation of indolent systemic mastocytosis

Vassilatou Evangeline , Gavoyiannakis Nickolas , Chatzipetrou Alexia , Koulias Christoforos , Makris Michael , Garoflos Eustathios , Hadjidakis Dimitrios , Rigopoulos Dimitrios , Dimitriadis George

Introduction: Systemic mastocytosis (SM) is a rare disorder characterised by clonal proliferation of abnormal mast cells in several tissues, most often skin and bone marrow. Indolent systemic mastocytosis (ISM) is the commonest disease variant in adults, characterised by very low rate of mast cell proliferation. SM has been recognised as a cause of secondary osteoporosis.Objective: To evaluate bone mineral density and fragility fractures in ISM patients....

ea0032p972 | Steroid metabolism and action | ECE2013

Differences in adipose tissue lipolysis in critically ill septic patients with and without shock

Vassiliadi Dimitra , Ilias Ioannis , Kopterides Petros , Nikitas Nikitas , Theodorakopoulou Maria , Diamantakis Argyris , Dimitriadis George , Boutati Eleni , Maratou Irini , Dimopoulou Ioanna

Introduction: Critical illness, and sepsis in particular, drives adipose tissue lipolysis up (with triglycerides (TG) being split to free fatty acids (FFA) and glycerol (GLYC)) to meet increased energy demands. Few studies have addressed lipolysis with tissue microdialysis (MD).Aim: To assess indexes of lipolysis in septic patients with and without shock.Subjects and methods: The study included 110 men and 73 women (mean age+<small...

ea0016p800 | Thyroid | ECE2008

Insulin resistance and oxidative stress induce advanced glycation end products formation in patients with clinical and subclinical hypothyroidism

Peppa Melpomeni , Hadjidakis Dimitrios , Alevizaki Maria , Dimitriadis George , Isari Georgia , Economopoulos Theofanis , Uribarri Jaime , Vlassara Helen , Raptis Sotirios A

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism – overt (OH) or subclinical (SUH) – is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...

ea0099p261 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Familial partial lipodystrophy:genetic and clinical data from a greek referral center

Kountouri Aikaterini , Korakas Emmanouil , Maratou Eirini , Ikonomidis Ignatios , Balampanis Konstantinos , Pliouta Loukia , Liatis Stavros , Tentolouris Nikolaos , Toulas Panagiotis , Kousathana Foteini , Giatzakis Christoforos , Dimitriadis George , Lambadiari Vaia

Background: Familial partial lipodystrophy (FPLD) is a rare syndrome in which a patient’s phenotype is not dependent merely on the specific genetic mutation, but also on a combination of other demographic, environmental and genetic factors. In this report, we present a large cohort of novel mutation in FPLD patients from a large referral center in Greece and we investigate the possible relationship between the genetic variations detected and their phenotype and the effect...

ea0099p464 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Combined dulaglutide-dapagliflozin treatment improves vascular dysfunction and albuminuria vs DPP4 inhibitors independently of glycaemic control

Korakas Emmanouil , Ikonomidis Ignatios , Thymis John , Kountouri Aikaterini , Pliouta Loukia , Katogiannis Konstantinos , Benas Dimitris , Balampanis Konstantinos , Prentza Vasiliki , Kousathana Foteini , Kostelli Gavriela , Dimitriadis George , Raptis Athanasios , Lambadiari Vaia

Background: The association between diabetes mellitus and diabetic nephropathy with vascular and endothelial properties is well-established. In this study, we compared the effect of combined treatment with dulaglutide and dapagliflozin versus DPP-4 inhibitors on endothelial glycocalyx, arterial stiffness, myocardial function and albuminuria in patients with type 2 diabetes mellitus and albuminuria.Methods: A total of 60 patients with type 2 diabetes mell...