Endocrine Abstracts

Overnutrition, increased macronutritient intake, physical inactivity, and ageing are associated with expansion of adipose tissue mass and cytokines, favoring in genetically and metabolically susceptible subjects, the development of insulin resistance, metabolic syndrome and diabetes. Adipose tissue distribution in human is dependent on genetic and environmental factors. The control of the rate of filling of adipocytes seems to be the main factor determining the local, regional...

The research included 20 patients of average age 59±8.5 years (ranging from 45 to 75 years of age), of whom there were 8 male patients (40%) and 12 female patients (60%), with average diabetes duration of 4.8±3.16 years. In this group HbA1c levels ranged from 6.6% to 9.4%, while the average BMI level was 30±3.39 kg/m2. Prior to the introduction of gliclazide MR with the daily dosage of 30 mg, all the patients had been treated with metformin with the d...

Suppressive therapy with thyroxine is the standard conservative treatment for solitary benign thyroid nodules. However, factors which may influence the response to treatment remains controversal, as well as the risc of thyroxine administration.We prospectively evaluated the effects of twelve months thyroid-stimulating hormone suppression with Levothyroxine (L-T4) in reducing the volume of benign solitary nodules, and the effects of reduced...

Ghrelin is able to stimulate HPA axis in both humans and animals. Exaggerated ACTH and cortisol responses to ghrelin have been shown in patients with CD. Here we studied the role of ghrelin alone or in combination with CRH in the diagnosis of CD. In 21 CD patient (18 female, age 49.8±10.2 years, BMI 29.8±0.8 kg/m2, ten macroadenomas 11 microadenomas) we performed: i) ghrelin test (100 μg iv bolus) ii) CRH test (100 μg iv bolus) and iii) ghrelin+C...

Introduction: In adults, the most common cause of obstructive sleep apnoea is obesity. Other causes are anatomical craniofacial bony abnormalities, neurologic syndromes, alcohol and sedatives use, hypothyroidism, acromegaly and rarely thyroid goitre. Untreated obstructive sleep apnoea can lead to serious complications, including cardiovascular diseases, accidents, and premature death.Case report: A 56-year-old patient was referred to a pulmologist due to...

Introduction: Primary thyroid lymphoma (PTL) presents between 2 and 8% of all thyroid malignancies. Rapidly enlarging neck mass, especially in women with Hashimoto’s thyroiditis should steer the diagnostic procedures in the way of PTL. The most common type is diffuse large B-cell lymphoma. Adrenal incidentaloma are incidentally discovered adrenal masses without prior suspicion of adrenal disease.Case report: A 71-year-old woman with an adrenal incid...

Introduction: Gastric bypass surgery in obese patients results in weight loss, changes in gastrointestinal and pancreatic hormones and improvement of insulin sensitivity.Methods: GLP-1, insulin and glucose levels were measured after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5, 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase);GLP-1 (Active 7–36) (pM/l; ...

Introduction: Adrenal glands consist of two parts: adrenal cortex and adrenal medulla acting as two separate organs due to distinct structure, function and embryologic origin. Corticomedullary mixed tumor is an adrenal tumor mass which consists of mixed population of both adrenal cortical cells and medullar chromaffin cells.Case report: A 36-year-old woman was admitted to our Clinic with hypertensive episode, headache and palpitation. Ultrasound and CT c...

Introduction: Schwannomas are tumors derived from myelin sheat of nerves which can displace and compress nerves causing pain, weakness and numbness. Very rarely they become malignant.Case report: Thirty-one years old patient was hospitalized at our Department to evaluate hypopituitarism. He was born at term by cesarean section, with hydrocephalus and did not start to breath spontaneously. A few months later, he was diagnosed with scoliosis thoracalis dup...

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...