Searchable abstracts of presentations at key conferences in endocrinology

ea0016me1 | (1) | ECE2008

The impact of abdominal obesity

Micic Dragan

Overnutrition, increased macronutritient intake, physical inactivity, and ageing are associated with expansion of adipose tissue mass and cytokines, favoring in genetically and metabolically susceptible subjects, the development of insulin resistance, metabolic syndrome and diabetes. Adipose tissue distribution in human is dependent on genetic and environmental factors. The control of the rate of filling of adipocytes seems to be the main factor determining the local, regional...

ea0022p278 | Diabetes | ECE2010

Assessment of the therapeutic effectiveness of gliclazide MR after short-term application

Milenkovic-Vulovic Koviljka , Micic Dragan , Polovina Snezana

The research included 20 patients of average age 59±8.5 years (ranging from 45 to 75 years of age), of whom there were 8 male patients (40%) and 12 female patients (60%), with average diabetes duration of 4.8±3.16 years. In this group HbA1c levels ranged from 6.6% to 9.4%, while the average BMI level was 30±3.39 kg/m2. Prior to the introduction of gliclazide MR with the daily dosage of 30 mg, all the patients had been treated with metformin with the d...

ea0016p783 | Thyroid | ECE2008

Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume and prevention the growth of solitary thyroid nodules

Mijailovic Vesna , Mijailovic Milan , Micic Dragan

Suppressive therapy with thyroxine is the standard conservative treatment for solitary benign thyroid nodules. However, factors which may influence the response to treatment remains controversal, as well as the risc of thyroxine administration.We prospectively evaluated the effects of twelve months thyroid-stimulating hormone suppression with Levothyroxine (L-T4) in reducing the volume of benign solitary nodules, and the effects of reduced...

ea0037gp.21.04 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Exaggerated and additive ACTH responses following the combined ghrelin+CRH test in patients with Cushing's disease

Miljic Dragana , Polovina Snezana , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Petakov Milan , Popovic Vera , Micic Dragan

Ghrelin is able to stimulate HPA axis in both humans and animals. Exaggerated ACTH and cortisol responses to ghrelin have been shown in patients with CD. Here we studied the role of ghrelin alone or in combination with CRH in the diagnosis of CD. In 21 CD patient (18 female, age 49.8±10.2 years, BMI 29.8±0.8 kg/m2, ten macroadenomas 11 microadenomas) we performed: i) ghrelin test (100 μg iv bolus) ii) CRH test (100 μg iv bolus) and iii) ghrelin+C...

ea0037ep1257 | Clinical Cases–Thyroid/Other | ECE2015

Incidental papilar carcinoma and large goitre in extremely obese patient with excessive daytime sleepiness

Tancic-Gajic Milina , Vujovic Svetlana , Vukcevic Miodrag , Ivovic Miomira , Marina Ljiljana , Arizanovic Zorana , Micic Dragan

Introduction: In adults, the most common cause of obstructive sleep apnoea is obesity. Other causes are anatomical craniofacial bony abnormalities, neurologic syndromes, alcohol and sedatives use, hypothyroidism, acromegaly and rarely thyroid goitre. Untreated obstructive sleep apnoea can lead to serious complications, including cardiovascular diseases, accidents, and premature death.Case report: A 56-year-old patient was referred to a pulmologist due to...

ea0035p233 | Clinical case reports Pituitary/Adrenal | ECE2014

Primary thyroid lymphoma in a patient with adrenal incidentaloma

Ivovic Miomira , Marina Ljiljana , Vujovic Svetlana , Tancic-Gajic Milina , Arizanovic Zorana , Rakovic Dragana , Micic Dragan

Introduction: Primary thyroid lymphoma (PTL) presents between 2 and 8% of all thyroid malignancies. Rapidly enlarging neck mass, especially in women with Hashimoto’s thyroiditis should steer the diagnostic procedures in the way of PTL. The most common type is diffuse large B-cell lymphoma. Adrenal incidentaloma are incidentally discovered adrenal masses without prior suspicion of adrenal disease.Case report: A 71-year-old woman with an adrenal incid...

ea0035p765 | Obesity | ECE2014

GLP-1, insulin and glucose levels during mixed test meal before and after gastric bypass surgery in obese patients

Micic Dragan , Polovina Snezana , Jeremic Danka , Micic Dusan , Sumarac-Dumanovic Mirjana

Introduction: Gastric bypass surgery in obese patients results in weight loss, changes in gastrointestinal and pancreatic hormones and improvement of insulin sensitivity.Methods: GLP-1, insulin and glucose levels were measured after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5, 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase);GLP-1 (Active 7–36) (pM/l; ...

ea0032p227 | Clinical case reports – Pituitary/Adrenal | ECE2013

Corticomedullary mixed adrenal tumor

Ivovic Miomira , Vujovic Svetlana , Tancic-Gajic Milina , Marina Ljiljana , Arizanovic Zorana , Micic Dragan

Introduction: Adrenal glands consist of two parts: adrenal cortex and adrenal medulla acting as two separate organs due to distinct structure, function and embryologic origin. Corticomedullary mixed tumor is an adrenal tumor mass which consists of mixed population of both adrenal cortical cells and medullar chromaffin cells.Case report: A 36-year-old woman was admitted to our Clinic with hypertensive episode, headache and palpitation. Ultrasound and CT c...

ea0032p251 | Clinical case reports – Pituitary/Adrenal | ECE2013

Malignant schwannoma in a patient with hypopituitarism, congenital hydrocephalus, atrial septal defect and agenesis of right kidney

Marina Ljiljana , Vujovic Svetlana , Barac Marija , Ivovic Miomira , Tancic-Gajic Milina , Arizanovic Zorana , Micic Dragan

Introduction: Schwannomas are tumors derived from myelin sheat of nerves which can displace and compress nerves causing pain, weakness and numbness. Very rarely they become malignant.Case report: Thirty-one years old patient was hospitalized at our Department to evaluate hypopituitarism. He was born at term by cesarean section, with hydrocephalus and did not start to breath spontaneously. A few months later, he was diagnosed with scoliosis thoracalis dup...

ea0032p1003 | Thyroid (non-cancer) | ECE2013

Thyroid-stimulating hormone and insulin resistance indexes in women with polycystic ovary syndrome

Sumarac-Dumanovic Mirjana , Jeremic Danka , Stamenkovic-Pejkovic Danica , Milin Jelena , Cvijovic Goran , Micic Dragan

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...