Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep713 | Pituitary and Neuroendocrinology | ECE2020

Pregnancy and pituitary adenomas: A case series

Dumitriu Roxana , Dusceac Roxana , Florentina Burcea Iulia , Baciu Ionela , Capatina Cristina , Dumitrascu Anda , Poiana Catalina

Introduction: Pituitary tumours may interfere with fertility and pregnancy may be uncommon in these cases, but some patients can conceive spontaneous. Also in pregnancy, due to the physiologic changes of the pituitary gland, gradual volume increase and cellular hyperplasia that target hormonal secretion, the evaluation of the pituitary function is very complex.Clinical cases: We present 5 cases of female patients (24 – 35 years old) that were diagn...

ea0070ep121 | Bone and Calcium | ECE2020

Teriparatide in the treatment of severe osteoporosis: Results of a case series

Florentina Burcea Iulia , Dusceac Roxana , Poiana Catalina

Introduction: Known as a potent anabolic drug, teriparatide has a stimulating effect on bone formation, increasing bone mineral density (BMD) and reducing fracture risk.Methods: 11 Caucasian women (mean age 66 years old) with severe osteoporosis treated with recombinant human parathyroid hormone (1–34) – teriparatide (Forsteo) 20 micrograms daily for 24 months were added to the study.BMD at lumbar spine, total hip and f...

ea0090p3 | Adrenal and Cardiovascular Endocrinology | ECE2023

Late onset congenital adrenal hyperplasia after the fifth decade of life: case series

Zaifu Laura , Dusceac Roxana , Naglabeala Laura , Niculescu Dan , Poiana Catalina

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that is caused by mutations of genes involved with adrenal steroidogenesis. The mutations mostly occur in the 21-hydroxylase gene and rarely in the 3β-hydroxysteroid dehydrogenase gene or 11β-hydroxylase genes. Our aim is to present a series of 3 cases of patients with late onset CAH, probably due to 21-hydroxylase deficiency, after 50 years of age.Case series...

ea0067gp10 | Poster Presentations | EYES2019

Advanced metastatic sporadic medullary thyroid carcinoma: a case of thirty-year survival with progressive disease

Sorohan Madalina , Dusceac Roxana , Dumitrascu Anda , Poiana Catalina

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

ea0063p109 | Calcium and Bone 1 | ECE2019

Evaluation of bone quality in acromegaly and thyrotoxicosis using trabecular bone score

Sorohan Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Trabecular bone score (TBS) evaluates bone microarchitecture by measuring the grey-level variations from lumbar spine dual-energy X-ray absorbtiometry (DXA) images. Bone mineral density (BMD) in various endocrinopathies might not be sufficient in assessing bone fragility, especially in patients with acromegaly (ACM) but also in thyrotoxicosis. The aim of our study was to evaluate bone quality and quantity by BMD and TBS in patients with acromegaly and thyrotoxicosis.<p cla...

ea0056p468 | Diabetes complications | ECE2018

Predictors for low bone mineral density assessed with DXA and trabecular bone score in patients with diabetes mellitus

Dragne Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Background: Diabetes mellitus is a metabolic disease associated with an increased risk of fracture, despite normal or increased bone mineral density (BMD), especially type 2 diabetes mellitus (T2DM). Trabecular bone score (TBS) is an imaging investigation that measures the grayscale variations on the lumbar spine performed on the DXA machine. The aim of this study was to evaluate the determinants associated with low BMD and TBS in patients with type 1 and type 2 diabetes melli...

ea0073aep568 | Pituitary and Neuroendocrinology | ECE2021

Managing pituitary disease during COVID-19 pandemic: A case report

Dumitriu Roxana , Burcea Iulia Florentina , Dusceac Roxana , Poiana Catalina

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

ea0073ep127 | Endocrine-Related Cancer | ECE2021

Advanced metastatic disease in a low-grade pulmonary neuroendocrine tumor: a case report with partial response to targeted therapy

Cristiana Calin , Dusceac Roxana , Burcea Iulia-Florentina , Catalina Poiana

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

ea0049ep1018 | Pituitary - Clinical | ECE2017

Disposition index in active acromegaly: A pilot study

Niculescu Dan Alexandru , Dusceac Roxana , Caragheorgheopol Andra , Popescu Nicoleta , Poiana Catalina

Background: Active acromegaly is characterized by decreased insulin sensitivity (ISen). However, insulin secretion (ISec) may not increase satisfactorily to compensate for the low ISen.Aim: To assess ISen and ISec and to calculate disposition index (DI) using an intravenous glucose tolerance test (IVGTT) in patients with active acromegaly.Methods: Twelve patients (7 men, 5 women) with active acromegaly and 2 normal subjects (2 men)...

ea0035p892 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Pituitary incidentaloma: an age-related study in 266 Romanian patients

Poiana Catalina , Carsote Mara , Ene Cristina , Mihai Alexandra , Dumitrascu Anda , Dusceac Roxana , Niculescu Dan , Peretianu Dan

Introduction: The pituitary tumors which are considered pituitary incidentalomas are accidentally discovered at pituitary scan and they associate a lack of pituitary hyper-secretion. Opposite to what generally are considered for adrenal incidentalomas, the pituitary incidentalomas are more frequent with years of life.Aim: We analyzed the incidentaloma sizes related to decades of age.Material and method: This is a retrospective stud...