Searchable abstracts of presentations at key conferences in endocrinology

ea0081p659 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of copeptin levels during glucagon stimulation test in children with suspected growth hormone deficiency

Ferrante Emanuele , Giacchetti Federico , Indirli Rita , Profka Eriselda , Rodari Giulia , Giavoli Claudia , Mantovani Giovanna , Arosio Maura

Introduction: Glucagon stimulation test is one of the recommended growth hormone provocation tests for diagnosing growth hormone deficiency in children. In adult patients, recent data showed that glucagon administration is able to stimulate the release of copeptin, the stable C-terminal glycopeptide of the AVP prohormone whose evaluation during hypertonic saline infusion represents the gold standard for the differential diagnosis of polyuria/polydipsia. However, similar data o...

ea0063gp237 | Anterior and Posterior Pituitary | ECE2019

Diagnostic accuracy of copeptin in the diagnosis of diabetes insipidus after pituitary surgery

Ferrante Emanuele , Serban Andreea , Sala Elisa , Cremaschi Arianna , Grassi Giorgia , Locatelli Marco , Arosio Maura , Mantovani Giovanna

Background: Routine clinical use of arginine-vasopressin (AVP) is limited by its small molecular size and pre-analytical errors. In contrast, copeptin – a peptide of 39 amino acids co-secreted with arginine-vasopressin (AVP) - is a stable protein and its measurement represents a reliable measure of AVP concentration. The aim of this study was to analyze diagnostic role of copeptin in diagnosis of diabetes insipidus (DI) in patients treated for hypothalamic-pituitary disea...

ea0014p532 | (1) | ECE2007

Growth hormone deficiency and recombinant hGH (rhGH) replacement in children with idiopathic isolated GH deficiency: effects on the hypothalamus-pituitary-adrenal axis

Bergamaschi Silvia , Giavoli Claudia , Ferrante Emanuele , Rusconi Roberto , Lania Andrea G , Spada Anna , Beck-Peccoz Paolo

Cortisol and cortisone are interconverted by type 1 and type 2 11ßhydroxysteroid dehydrogenase (11ßHSD) isoenzymes. The type 1 isoenzyme is a widely expressed reductase that converts cortisone to cortisol regulating glucocorticoid tissue exposure. Its activity is inhibited by GH and IGF-I, being increased in GH deficiency (GHD) and decreased in acromegaly. In our experience rhGH therapy unmasked a central hypoadrenal state in adults with organic GHD, likely by normal...

ea0056p823 | Pituitary - Clinical | ECE2018

Recovery of the adrenal function after pituitary surgery in patients with Cushing Disease: remission or recurrence?

Serban Andreea , Verrua Elisa , Sala Elisa , Locatelli Marco , Arosio Maura , Mantovani Giovanna , Ferrante Emanuele

Background: The treatment of choice in patients with Cushing Disease (CD) is pituitary surgery (PS). A successful PS is generally followed by adrenal insufficiency (AI). Although the remission rate after PS may reach 96.6% of cases, approximately 1/3 of cured patients experience the recurrence of the disease during lifetime. The aim of this study was to analyze the duration of AI in relation with the recurrence of CD.Materials and methods: We performed a...

ea0081ep869 | Reproductive and Developmental Endocrinology | ECE2022

Procoagulant imbalance in male hypogonadism and effect of short-term testosterone replacement therapy

Indirli Rita , Clerici Marigrazia , Lanzi Valeria , Profka Eriselda , Cangiano Biagio , Bonomi Marco , Arosio Maura , Mantovani Giovanna , Tripodi Armando , Ferrante Emanuele

Introduction: The effects of testosterone on coagulation have not yet been clarified. In particular, it is still controversial whether male hypogonadism, or testosterone replacement therapy (TRT), may slightly increase the risk of venous thromboembolism, in particular during the first months of therapy. This study aimed to assess the hemostatic balance in hypogonadal men before and after short-term TRT, compared to healthy controls.Methods: Thrombin gene...

ea0090oc8.1 | Oral Communications 8: Calcium and Bone | ECE2023

Clinical picture of early infancy PTH-resistance syndromes: is it time to improve diagnostic criteria?

Del Sindaco Giulia , Pagnano Angela , Berkenou Jugurtha , Ferrante Emanuele , Rothenbuhler Anya , Arosio Maura , Mantovani Giovanna , Linglart Agnes

Since the first description of inactivating PTH/PTHrP signaling disorders (iPPSDs, historically named pseudohypoparathyroidism (PHP)) a remarkable clinical variability was observed, especially in clinical presentation, which seems to be age-dependent. The main clinical features, including PTH resistance, brachydactyly and short stature, develop during mid and late childhood, whilst minor clinical features such as a round face, rapid weight gain and subclinical hypothyroidism a...

ea0090p576 | Calcium and Bone | ECE2023

Hypercalcitoninemia in a large cohort of adult and paediatric patients with PTH-resistance syndromes

Cremaschi Arianna , Del Sindaco Giulia , Pagnano Angela , Dolci Alessia , Contarino Andrea , Ferrante Emanuele , Arosio Maura , Linglart Agnes , Mantovani Giovanna

Inactivating PTH/PTHrP signaling disorders (iPPSDs, historically named pseudohypoparathyroidism (PHP)) are a group of rare disorders associated with resistance to parathormone (PTH) and other hormones due to impaired hormonal signaling via G protein coupled receptors. Hypercalcitoninemia has been reported in these patients, however very few reports are available. The aim of this study was to further investigate the prevalence and characteristics of hypercalcitoninemia in both ...

ea0090p142 | Pituitary and Neuroendocrinology | ECE2023

Characterization of a large cohort of patients with “micromegaly”: long-term follow-up and preliminary data on treatment response

Carosi Giulia , Mangone Alessandra , Sala Elisa , Del Sindaco Giulia , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Background: In a previous study, we retrospectively analysed a group of patients with high insulin growth factor 1 (IGF1) but normal growth hormone (GH) suppression, identifying among them a subgroup of “micromegalic” patients presenting with clinical features of acromegaly and high rate of comorbidities. We therefore expanded our cohort of patients, extended the follow-up time and collected preliminary data on treatment response aiming to better characterize this co...

ea0063p725 | Pituitary and Neuroendocrinology 2 | ECE2019

Remission rate of acromegaly after somatostatin analogs withdrawal: an update

Carosi Giulia , Sala Elisa , Sindaco Giulia Del , Verrua Elisa , Serban Andreea Liliana , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Objective: Several studies reported that a long-time therapy with somatostatin analogs (SSTa) in acromegaly could induce persistent remission event after drug withdrawal. The aim of this study was to evaluate GH/IGF-I secretion after SSTa discontinuation in a series of acromegalic patients.Materials and methods: Data of 21 patients regularly referred to our Centre and previously included in a multicentre study, have been updated at the last available fol...

ea0063p790 | Thyroid 2 | ECE2019

The prevalence of macro TSH in patients with subclinical hypothyroidism: experience of a single centre

Serban Andreea , Ferrante Emanuele , Maregnani Alessio , Grassi Giorgia , Mantovani Giovanna , Beck-Peccoz Paolo , Ceriotti Ferruccio , Arosio Maura

Background: Subclinical hypothyroidism (SH) is a frequent clinical condition with a prevalence of 3–15% in general population. It is defined by elevated TSH levels with normal thyroid hormones [free thyroxine (FT4) and free triiodothyronine (FT3)]. Similar to prolactin, high TSH levels may be caused by macroTSH, a large molecular sized TSH with a low bioactivity. The aim of the study was to assess the prevalence of macroTSH in patients with subclinical hypothyroidism....