Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder with an estimated prevalence of 1 per 30,000 in the general population. MEN2 is subclassified into two distinct syndromes: types 2A (MEN2A) and 2B (MEN2B). MEN2A and 2B are inherited in an autosomal dominant pattern with very high penetrance. In both syndromes, there is an occurrence of multicentric tumour formation in all organs where the RET proto-oncogene is expressed.<p ...

Introduction: The most common cause of loss of adequate substitution on a stable dose of replacement therapy is noncompliance. Impaired absorption and weight gain are also possible. We present a rare case of renal loss of thyroxin in severe nephritic syndrome.Case report: We present a 46 year old female after total thyroidectomy for Graves-Basedow disease. From 2005 she was euthyroid on a stable dose of L-thyroxin (100 μg/day). On phy...

Introduction: Lymphomas account for <5% of thyroid malignancies. The vast majority of them are non-Hodgkin’s lymphomas (NHL), especially mucosa-associated lymphoid tissue lymphomas (MALT) and diffuse large B-cell lymphomas (DLBCL). However, Hodgkin’s lymphoma affecting thyroid gland is very rare. Worldwide has been reported <50 cases so far and we describe another one.Case report: A 22-year-old woman was referred to our department of en...

Prolactinomas are the most common hormonally active tumours of the pituitary. The treatment of choice is pharmacological. They are treated with cabergolin, which decreases the level of prolactin as well as the size of the tumour. Rarely, dangerous complications can arise after a quick reduction of the tumour’s size.Case presentation: Two men with macroprolactinomas were initially treated with cabergoline (Dostinex®) in a dose of 1 mg per week w...

IntroductionPapillary thyroid cancer (PTC) has generally good prognosis irrespective of lymph node metastases. The rate of survival in patients with distant metastases is variable, depending upon the site of metastases and radioiodine accumulation status. The median survival of patients with brain metastases is approximately one year.CaseWe present a 66 years old woman with a tumour triplicity (PTC, breast ca...

Introduction: Dilated cardiomyopathy is the third most common reason for heart failure and transplantation worldwide. The etiology of dilated cardiomyopathy often remains unclear, but in certain cases we can discover the cause, which can then contribute to better and more causal treatment.Observation: We present a case of a 47-year-old man without any significant comorbidities in his medical history. In 2015 he underwent two hemithyroidectomies with a ne...

Paraneoplastic manifestations of well-differentiated thyroid carcinoma are not so common but they can be the first signal of cancer. We present a case of a man with Raynaud’s phenomenon in the area of the lower limb fingers. Clinical signs of Raynaud’s phenomenon with ulceration and gangrene of fingers of both lower limbs appeared several months before the diagnosis of papillary microcarcinoma of the thyroid was made. The diagnosis of carcinoma of the thyroid was det...

Introduction: Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the evaluation and the treatment of LCH.Case: 39 years old woman has had amenorrhea for 2 years and higher intake of fluids (5–7 l/day) for 6 years. Non-functioning pitu...

Introduction: A transsphenoidal adenectomy (TSFE) is primary treatment of Cushing’s disease. Pharmacological management when the disease persists after surgery is a challenge.Case report: A 47-year-old man was initially diagnosed with CD (petrosal sinus sampling with CRH testing included) after suffering from multiple organ failure in sepsis. Microadenoma 2×4 mm was suspected on the pituitary MRI. Clinical symptoms were markedly improved after ...

Primary hyperparathyroidism (PHPT) is rarely caused by parathyroid adenoma with cystic degeneration, especially by the cyst localized in mediastinum. Both differential diagnosis of mediastinal cyst and management of the patient can be challenging.Case presentation: A 57 years old woman was transferred from district hospital where her urosepsis and nephrolithiasis had been treated successfully. A liquid collection in left hemithorax had also been found du...