Searchable abstracts of presentations at key conferences in endocrinology

ea0022p813 | Thyroid | ECE2010

Association of Pro12Ala PPAR-γ gene polymorphism with Graves' orbitopathy

Daroszewski Jacek , Pawlak Edyta , Bolanowski Marek , Frydecka Irena

Introduction: Peroxisome proliferation-activated receptors-γ (PPAR-γ) have been shown to be involved in adipogenesis as well as in immunoregulation and inflammation control. Orbital fibroblast differentiation to adipocytes is a PPAR-γ dependent process essential for pathogenic tissue remodeling in Graves orbitopathy (GO).Purpose: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the ...

ea0014p336 | (1) | ECE2007

Soluble CTLA-4 is increased in Graves’ disease and not related to thyroid status or ophthalmopathy severity

Daroszewski Jacek , Pawlak Edyta , Bolanowski Marek , Slowik Miroslaw , Frydecka Irena

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a B7-binding protein that plays an important role in the down-regulation of T-cell activation. CTLA-4 function is closely associated with predisposition to autoimmune diseases. A native soluble form of CTLA-4 (sCTLA-4) is reported to be present in the sera of patients suffering from autoimmune thyroid disease. In this study we report data on sCTLA-4 concentrations in patients with clinical expression of Graves’ disease.<p c...

ea0020oc5.5 | Thyroid: Basic and Clinical | ECE2009

Graves patients with high sCTLA-4 level are at risk of severe ophthalmopathy

Daroszewski Jacek , Pawlak Edyta , Karabon Lidia , Bolanowski Marek , Jonkisz Anna , Frydecka Irena

Objectives: Graves' disease (GD) is an autoimmune disease caused by combination of environmental and genetic factors. The CTLA-4 gene is a candidate gene for conferring susceptibility to thyroid autoimmunity. Increased serum level of soluble isoform of CTLA-4 molecule (sCTLA-4), resulting by alternative splicing, was found in some autoimmune diseases. The role of this molecule in the pathomechanism of autoimmunity has not been defined.The principa...

ea0035p986 | Thyroid (non-cancer) | ECE2014

Polymorphisms within genes encoding co-stimulatory molecules modulate the susceptibility to Graves' disease and orbitopathy

Daroszewski Jacek , Pawlak-Adamska Edyta , Przemyslaw Janusz , Frydecka Irena , Karabon Lidia , Jonkisz Anna , Tomkiewicz Anna , Partyka Anna , Lebioda Arleta , Bolanowski Marek

The clinical presentation of Graves’ disease (GD) depends on the combination of environmental and genetic factors. The CTLA-4 and CD28, ICOS genes encoding negative and positive regulator of the T-lymphocyte immune response, are candidate genes for conferring susceptibility to thyroid autoimmunity.Polymorphisms in genes: CTLA-4: g.319C>T (rs5742909), c.49A>G (rs231775), g.*642AT(8_33), CT60 (g.*6230G>A, rs3087243), Jo31...

ea0014oc1.5 | Thyroid clinical | ECE2007

CTLA- 4 gene polymorphisms and autoimmune thyroid diseases: meta-analyses of published and individual-level data

Kavvoura Fotini , Akamizu Takashi , Awata Takuya , Ban Yoshiyuki , Chistiakov Dimitry , Frydecka Irena , Ghaderi Abbas , Gough Stephen , Hiromatsu Yuji , Ploski Rafal , Wang Pei-Wen , Ban Yoshio , Bednarczuk Tomasz , Chistiakova Emma , Chojm Marcin , Heward Joanne , Hiratani Hitomi , Juo Suh-Hang Hank , Karabon Lidia , Katayama Shigehiro , Kurihara Susumu , Liu Rue-Tsuan , Miyake Ikuyo , Omrani Gholam-Hossein , Pawlak Edyta , Taniyama Matsuo , Tozaki Teruaki , Ioannidis John PA

Background: CTLA-4 polymorphisms have been widely examined for their associations with autoimmune thyroid diseases (Graves’ disease [GD] and Hashimoto thyroiditis [HT]) but their relative population effect remains unclear.Methodology/Principal findings: Meta-analyses of group-level data from 32 (n=11.019 subjects) and 12 (n=4.479) published and unpublished studies were performed for the association of the A49G polymorphism with ...