Searchable abstracts of presentations at key conferences in endocrinology

ea0081p138 | Pituitary and Neuroendocrinology | ECE2022

Takayasu’s artheritis presenting as a large sellar mass with neurological and hypopituitarism manifestations

Galazzi Elena , Giancola Noemi , Citterio Valeria , Moro Mirella , Addobbati Laura , Avignone Sabrina , Capsoni Franco , Persani Luca

Introduction: Only one case of hypophysitis secondary to TakayasuÂ’s artheritis (TKA) has been described so far. We report the second case of a TKA presenting with a massive sellar and cerebrovascular infiltration.Clinical case: A 52 years-old female was referred to endocrine outpatient clinics after a brain MRI performed for a 2-year history of headaches, dizziness and general discomfort. Past medical history included hypertension and aspecific symp...

ea0081ep754 | Pituitary and Neuroendocrinology | ECE2022

Early diagnostic tools in milder forms of central hypothyroidism in patients harbouring a pituitary adenoma: cross-sectional study on 142 patients from a single tertiary center

Galazzi Elena , Nicoli Federico , Carrara Silvia , Milan Chiara , Fatti Letizia Maria , Moro Mirella , Persani Luca

Introduction: Milder forms of central hypothyroidism (CeH) are still challenging to diagnose due to absence of gold standards, wide variability of fT4 values and aspecificity of symptoms. We aimed to find diagnostic clues at diagnosis (pituitary lesion dimensions, other hormonal deficit) and during long-term follow-up, guiding the clinician to a precocious diagnosis of CeH.Study: 142 patients harbouring a pituitary adenoma with complete pituitary assessm...

ea0090p143 | Pituitary and Neuroendocrinology | ECE2023

Role of fT4 and TSH-index fluctuations as early diagnostic tools in milder forms of central hypothyroidism: data from 221 patients with pituitary lesions from a single tertiary center

Carrara Silvia , Galazzi Elena , Nicoli Federico , Moro Mirella , Fatti Letizia , Cangiano Biagio , Persani Luca

Diagnosis of Central Hypothyroidism (CeH) is commonly given when FT4 concentrations are below the lower limit of normal range. A reduction in FT4 concentrations greater than 20% was proposed in ETA 2018 Guidelines as an unphysiological fluctuation indicating the onset of milder forms of CeH with FT4 still within the normal range. Similarly, TSH-index was proposed to quantify thyrotrope reserve, hence as a tool to detect patients at risk of CeH. Here we verified the performance...

ea0090p67 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Study of the prevalence, clinical correlates, and cardiovascular outcomes of central and primary hypogonadism in type 2 diabetes mellitus

Cangiano Biagio , Elena Lunati Maria , Bollino Ruggiero , Conti Antonio , Galazzi Elena , Fiorina Paolo , Persani Luca , Bonomi Marco

Background: In patients affected with type 2 diabetes mellitus (T2DM) a high prevalence of hypogonadism has been reported, even if there is no consensus on its metabolic and cardiovascular implications, especially according to the type of hypogonadism. The aim of this observational study is to evaluate: (1) the prevalence of different types of hypogonadism in T2DM according to validated criteria from the EMAS study; (2) look for correlations of gonadal status with severity or ...

ea0090p736 | Reproductive and Developmental Endocrinology | ECE2023

The Impact of Covid-19 Lockdown on Pubertal Onset in A Second Level Center

Goggi Giovanni , Moro Mirella , Chila Alessandro , Fatti Letizia , Cangiano Biagio , Federici SIlvia , Galazzi Elena , Carbone Erika , Soranna Davide , Vezzoli Valeria , Persani Luca , Bonomi Marco

Background: As of December 2019, the COVID-19 pandemic has spread rapidly, therefore Governments from all over the world promoted a strategy of social confinement through a general lockdown in order to contain it. During the months following its introduction, many studies reported a significant increase in the incidence of idiopathic central precocious puberty (CPP) throughout several countries, especially in girls.Purpose: The aim of our study was to co...

ea0081ep668 | Pituitary and Neuroendocrinology | ECE2022

A multicenter retrospective study on a large cohort of patients with primary empty sella: hormonal and neuroradiological features over a long follow-up

Carosi Giulia , Brunetti Alessandro , Mangone Alessandra , Baldelli Roberto , Tresoldi Alberto , Sindaco Giulia Del , Lavezzi Elisabetta , Sala Elisa , Mungari Roberta , Fatti Letizia Maria , Galazzi Elena , Ferrante Emanuele , Indirli Rita , Biamonte Emilia , Arosio Maura , Cozzi Renato , Gerardo Antonio Lania Andrea , Mazziotti Gherardo , Mantovani Giovanna

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...