Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...

Introduction: IGF-I and its binding proteins may modulate cardiovascular risk. As part of our Manchester Mothers’ Cardiovascular study, we tested in pre-menopausal women the hypothesis that higher circulating IGF-I concentrations would be associated with lesser arterial stiffness and lower cardiac (LV) mass, while higher IGFBP1, reflecting less pre-hepatic insulin, would be positively related to small vessel function.Methods: About 193 women aged 32...

Introduction: Glucagon-like peptide-1(GLP-1) agonists are widely used for treatment of type 2 diabetes(T2D). To date a number of reports have described improvements in glucose control with the addition of a GLP-1 agonist to the insulin regime in treatment of type 1 diabetes(T1D). From a physiological perspective there is credence to the notion that a GLP-1 agonist will lower glucose levels in people with T1D as they do in T2D. GLP-1 is an endogenous hormone th...

Introduction: There is growing evidence of external factors modulating epigenetic modifications and their contribution to the development of obesity and T2DM. One of the epigenetic signatures is DNA methylation. We investigated whether a lifestyle intervention could influence DNA methylation of Brain derived neurotrophic factor (BDNF) in individuals with IGR, as BDNF is thought to play an important role in glucose metabolism.Methods: IGR participants (<e...

Introduction: Microvascular and macrovascular complications in type 1 diabetes T1D) may be linked to endothelial stress due to glycaemic variability. This work aimed to examine whether determination of glycaemic parameters including glucose variability (GV) over an 18month period is associated with microvascular clinical sequelae. Methods: Freestyle Libre 15-minute glucose values were downloaded for 89 T1DM individuals for up to 18 months from 2021 to 20...

Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there a...

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...