Searchable abstracts of presentations at key conferences in endocrinology

ea0077p39 | Metabolism, Obesity and Diabetes | SFEBES2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems and asthma pre-date diabetes diagnosis by many years

Heald Adrian , Fachim Helene , Stedman Mike , Gibson Martin , Anderson Simon G , Peng Yonghong , Ollier WiIliam

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

ea0031p137 | Cytokines and growth factors | SFEBES2013

Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI

Narayanan Ram Prakash , Fu Bo , Payton Antony , Donn Rachelle , Heald Adrian , Ollier William ER , Gibson Martin

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...

ea0015p109 | Cytokines and growth factors | SFEBES2008

Relationships of IGF-I and its binding proteins to cardiac, large and small vessel structure and function in premenopausal women

Banerjee Moulinath , Austin Clare , Vyas Avni , Siddals Kirk , Gibson Martin , Malik Rayaz , Cruickshank Kennedy

Introduction: IGF-I and its binding proteins may modulate cardiovascular risk. As part of our Manchester MothersÂ’ Cardiovascular study, we tested in pre-menopausal women the hypothesis that higher circulating IGF-I concentrations would be associated with lesser arterial stiffness and lower cardiac (LV) mass, while higher IGFBP1, reflecting less pre-hepatic insulin, would be positively related to small vessel function.Methods: About 193 women aged 32...

ea0094p230 | Metabolism, Obesity and Diabetes | SFEBES2023

Case report - success story of GLP-1 agonist (liraglutide) treatment in someone with type 1 diabetes: A life transformed

Heald Adrian , Whyte Martin , Warner-Levy John , Belston Lleyton , Horne LInda , Gibson Martin

Introduction: Glucagon-like peptide-1(GLP-1) agonists are widely used for treatment of type 2 diabetes(T2D). To date a number of reports have described improvements in glucose control with the addition of a GLP-1 agonist to the insulin regime in treatment of type 1 diabetes(T1D). From a physiological perspective there is credence to the notion that a GLP-1 agonist will lower glucose levels in people with T1D as they do in T2D. GLP-1 is an endogenous hormone th...

ea0065p176 | Metabolism and Obesity | SFEBES2019

Brain derived neurotrophic factor (BDNF) methylation in patients with impaired glucose regulation: implications progression to type 2 diabetes mellitus (T2DM)

Fachim Helene , Siddals Kirk , Malipatil Nagaraj , Cortes Gabriela , Donn Rachelle , Dalton Caroline , Reynolds Gavin , Gibson Martin , Heald Adrian

Introduction: There is growing evidence of external factors modulating epigenetic modifications and their contribution to the development of obesity and T2DM. One of the epigenetic signatures is DNA methylation. We investigated whether a lifestyle intervention could influence DNA methylation of Brain derived neurotrophic factor (BDNF) in individuals with IGR, as BDNF is thought to play an important role in glucose metabolism.Methods: IGR participants (<e...

ea0077p173 | Metabolism, Obesity and Diabetes | SFEBES2021

Associations between reduction in body mass index (BMI) and proteins linked to neural function after 12 months of bariatric surgery

Fachim Helene , Iqbal Zohaib , Gibson Martin , Baracevic-Jones Ivonna , Campbel Amy , Geary Bethany , Donn Rachelle , Syed Akheel , Whetton Antony , Soran Handrean , Heald Adrian

Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there a...

ea0065p190 | Metabolism and Obesity | SFEBES2019

Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes – a 14-year follow up study

Heald Adrian , Yadegarfar Ghasem , Livingston Mark , Fachim Helene , Lunt Mark , Narayanan Ram Prakash , Siddals Kirk , Cortes Gabriela , Hackett Geoff , Naseem Asma , Kochhar Rupinder , Inamullah Khan , Donn Rachelle , Gibson Martin , Jones Hugh

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...