Searchable abstracts of presentations at key conferences in endocrinology

ea0063p244 | Pituitary and Neuroendocrinology 1 | ECE2019

Effects of octreotide on hallmarks of autophagy and on parameters related to cell viability and metabolic activity in rat pituitary tumor cells

Tulipano Giovanni , Giustina Andrea

We investigated the direct effects of the somatostatin analog octreotide on hallmarks of autophagy and of cell viability and metabolic activity in rat pituitary tumor cells (GH1 and GH3 cells). The Western blot analysis of cell lysates suggested that octreotide (100 nM) treatment could induce changes in hallmarks related to autophagy activation (increased LC3-I protein lipidation) and to enhanced autophagic flux (SQSTM1/p62 protein downregulation) in pituitary tumor cells in d...

ea0081ep700 | Pituitary and Neuroendocrinology | ECE2022

A Delphi panel of Italian endocrinologists to define the unmet needs on the current management of Cushing’s Syndrome

Pivonello Rosario , Carla Scaroni , Polistena Barbara , Migliore Antonio , Giustina Andrea

Introduction: Cushing’s Syndrome (CS) requires an accurate diagnosis, patient-tailored treatments and long-term management. To define the unmet needs of patients with CS, a consensus among a panel of Italian endocrinologists was promoted. The panel involved 57 specialists with expertise in CS management.Methods: The endocrinologists were identified by convenience sampling. The survey was built around a set of statements formulated after literature r...

ea0049ep1020 | Pituitary - Clinical | ECE2017

European observational study of long-acting pasireotide for uncontrolled acromegaly: ACRONIS study design and rationale

Giustina Andrea , Enderle Gesine , Mesenka Daniela , Mondal Debolina , Schofl Christof

Introduction: Acromegaly is a rare, serious disease caused by the presence of a pituitary adenoma secreting an excessive amount of growth hormone (GH), which leads to a consequent increase in circulating insulin-like growth factor-1 (IGF-1) levels, and excessive skeletal growth and soft tissue enlargement. It is usually managed by surgery and/or treatment with somatostatin analogs (SSA). The ACRONIS study (CSOM230CIC05) will provide real-world evidence on the efficacy and safe...

ea0081p462 | Thyroid | ECE2022

Impact of COVID-19 vaccination on incidence of graves’ disease

Di Filippo Luigi , Valsecchi Fanny , Frara Stefano , Perticone Francesca , Castellino Laura , Giustina Andrea

Several reports of Graves’ disease (GD) onset after COVID-19 vaccination were recently published. The mechanism underlying GD occurrence in these cases could be related to the autoimmune syndrome induced by adjuvants (ASIA), a condition triggered by several vaccine adjuvants and excipients leading to dysfunctional immune response causing different conditions and endocrinopathies in genetically predisposed subjects. In Italy, population campaign for COVID-19 vaccination st...

ea0063p500 | Calcium and Bone 2 | ECE2019

Body mass index is a biomarker of resistance to active vitamin D but not to calcium supplementation, in patients with hypoparathyroidism

Tecilazich Francesco , Formenti Anna Maria , Frara Stefano , Resmini Eugenia , Doga Mauro , Giubbini Raffaele , Giustina Andrea

Background: Persistent Hypoparathyroidism (PH) is a condition characterized by inappropriately low concentrations of PTH that lead to hypocalcemia. The treatment cornerstones of PH are calcium and calcitriol supplementation; however, several patients do not achieve adequate control of the disease under this conventional therapy. Notably, no biomarker of risk of ‘resistance’ has yet been identified. Based on the fact that obesity alters the vitamin D-calcium homeostas...

ea0063p731 | Pituitary and Neuroendocrinology 2 | ECE2019

Therapeutic decisions in acromegaly according to disease control in patients with acromegaly with or without prior treatment: data from baseline analysis of the SAGIT® validation study

Giustina Andrea , Bronstein Marcello , Chanson Philippe , Petersenn Stephan , Casanueva Felipe , Sert Caroline , Houchard Aude , Melmed Shlomo

Background: The SAGIT® instrument, designed to assist clinicians in staging and managing acromegaly, is undergoing validation. A descriptive analysis of SAGIT Validation study baseline data revealed discrepancies between investigator-evaluated disease-control status, disease activity, hormonal control, and treatment decisions in acromegaly.Objective: To describe the baseline characteristics of patients in the SAGIT® valida...

ea0070aep1074 | Hot topics (including COVID-19) | ECE2020

ACROCOVID: An international survey on care for acromegaly during the COVID-19 era

Giustina Andrea , Mario Cesana Bruno , Marks Muriël , Mortini Pietro , Khawaja Sheila , Fleseriu Maria

The COVID-19 pandemic is significantly affecting the care of chronic conditions globally. Acromegaly is a rare chronic condition with a prevalence ranging between 2.8–13.7 cases/100.000 people. Acromegaly management requires a multidisciplinary team of health care professionals (HCPs), mainly including endocrinologists, neurosurgeons, and specialized endocrine nurses. Frequent consultations, particularly during early stages of the disease, and pre/post-surgery are necess...

ea0070aep1075 | Hot topics (including COVID-19) | ECE2020

COVID-19 and hypopituitarism. Experience from an endocrine center in a high-impact area

loli Paola , Frara Stefano , Pasquali Riccardo , Di Filippo Luigi , Rovere Querini Patrizia , Giustina Andrea

SARS-CoV-2 has rapidly spread from China throughout the world leading to a pandemic. COVID-19 can be severe enough to cause hospitalization and death. Many patients with endocrine disorders share many of the recognized risk factors for severe disease and have potential additional risks due to corticosteroid replacement therapy or alteration in blood electrolytes. We here report three cases of COVID-19 in patients with post-surgical hypopituitarism and documented hypocortisolem...

ea0070ep543 | Hot topics (including COVID-19) | ECE2020

Are women with osteoporosis treated with denosumab at risk of severe COVID-19?

Maria Formenti Anna , Pedone Erika , Di Filippo Luigi , Massimo Ulivieri Fabio , Giustina Andrea

Coronavirus disease 2019 (COVID-19), is a primarily respiratory infection which can lead to severe syndrome needing hospitalization and assisted ventilation with high lethality. In a recent meta-analysis of 33 RCTs increased risk of severe infections on treatment with Denosumab, widely used for treatment of osteoporosis, was found specifically for ear, nose, and throat. In fact, by inhibiting the receptor activator of nuclear factor κ-Β ligand, denosumab acts as an i...

ea0020p570 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effects of somatostatin analogs on glucose homeostasis: a meta-analysis of acromegaly studies

Mazziotti Gherardo , Floriani Irene , Bonadonna Stefania , Torri Valter , Chanson Philippe , Giustina Andrea

Objective: Somatostatin analogues (SSA) are widely used for the treatment of patients with neuroendocrine tumors. These drugs are able to influence glucose metabolism by an inhibitory effect of insulin secretion, but the clinical impact of this effect is uncertain. Most of the data on this topic have been obtained from studies including patients in acromegaly, one the major indication for SSA, which are limited in terms of numerosity and study duration. Therefore, we have carr...