Endocrine Abstracts

Introduction: Thyroid storm or thyrotoxic crisis is a severe manifestation of thyrotoxicosis. Mortality rate is 20-30%. The most common trigger is hyperthyroidism due to Graves-Basedow Disease. There are two validated scales for diagnosis: the Burch Wartofsky scale (BWPS) and the Japanese Thyroid Association scale (JTA). These scales are based on cardiovascular, neurological, digestive, and thermoregulatory clinical manifestations. If clinical suspicion is high, treatment shou...

Introduction: Ectopic Cushing Syndrome (ECS) is a rare disease associated with significant comorbidity. Among the causes of Cushing’s syndrome (CS), ACTH-producing extrahypophyseal tumours are rarely reported. The aim of our study is to describe the clinical, diagnostic and therapeutic characteristics of patients with ECS treated in our Endocrinology department over a 15-year period.Methods: A cross-sectional unicentric retrospective study was desi...

Introduction: Approximately 20% of neuroendocrine tumor (NET) patients experience carcinoid syndrome (CS), primarily associated with metastatic ileal NETs. CS manifests with symptoms such as diarrhea, flushes, and cardiac complications. Carcinoid heart disease (CHD) is a negative prognostic factor in NETs. However, the considerable variability in reported diagnoses and treatment approaches in the literature creates uncertainty about optimal management in this specific populati...

Introduction: Cavernous hemangiomas (CH) are benign vascular tumors that frequently involve the skin, central nervous system or liver. Rarely, they can also affect adrenal glands. Adrenal cavernous hemangiomas are mostly unilateral lesions, typically discovered incidentally on radiological imaging. They generally present in the sixth to seventh decade of life and tend to be asymptomatic and non-functioning tumors. Preoperative differential diagnosis from malignant neoplasms ow...

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...

Background: Inferior petrosal sinus sampling (IPSS) is indicated in the diagnosis of adrenocor-ticotropic hormone (ACTH)-dependent Cushing’s syndrome (CS), especially when the results of the initial diagnostic tests are discordant.Objective: To describe the patients who underwent this invasive functional test in a tertiary hospital.Methods: This was an observational study of a retrospective cohort of patients with ACTH- depend...

Introduction: The Bethesda system gives each Fine Needle Aspiration (FNA) category a risk of malignancy (B1: 5-10%, B2: 0-3%, B3: 10-30%, B4: 25-40%, B5: 50-75%, B6: 97-99%). Based on this risk, therapeutic decisions are made that influence the patient’s life. It is important to check whether the percentage of malignancy obtained in our daily clinical practice is similar to that expected according to this system.Aim: To check whether the percentage ...

Introduction: Pheochromocytoma, a rare catecholamine-secreting tumor, typically presents with paroxystic hypertension, tachycardia, headache, and diaphoresis. Less frequently, symptoms imply substantial hemodynamic compromise and cardiogenic shock may occur. The delay time in diagnosis is approximately 3 years.Case Presentation: This is a 41-year-old woman with no relevant history or cardiovascular risk factors, who presented with stress-induced cardiomy...

In our country, as in others, there is a lack of data on the success rate of transsphenoidal surgery for producing pituitary adenomas. We evaluated the results reported in TESSPAIN, a retrospective multicenter nationwide project that includes all the TSS performed in the participating centers in the period between 2018 and 2022, both included. Surgical treatment success is defined according to the published criteria for each disease: normal IGF-1 and GH after 75 g of oral gluc...

Aim: To investigate the impact of pituitary surgery on glucose metabolism and to identify predictors of diabetes remission after surgery in patients with acromegaly.Methods: A national multicenter retrospective study of acromegaly patients undergoing transsphenoidal surgery for the first time at 33 tertiary Spanish hospitals (ACRO-SPAIN study, n=604) was performed. Surgical remission was evaluated according to the 2000 and 2010 criteria. Glucose...