Endocrine Abstracts

Introduction: Isolated central hypothyroidism is a rare disease. Acquired causes for central hypothyroidism include iatrogenic, traumatic, immunologic, infiltrative, infectious, vascular or space-occupying lesions. Empty sella may present with endocrine dysfunction, mainly hyperprolactinemia and growth hormone or gonadotropin deficiency. Few cases of empty sella associated with isolated TSH deficiency were published.Case report: A 66-years-old female wit...

Introduction: TRH, thyroid hormones, dopamine, somatostatin and glucocorticoids have a recognized influence on TSH secretion. On the other hand, serotoninergic, histaminergic, catecholaminergic, opioidergic and GABAergic systems establish connections with hypophysiotropic neurons involved in TSH regulation; their relative contribution to TSH secretion is unknown. Still, there are a few reports of H1 receptor antagonists impact on TSH levels.Case report: ...

Introduction: On average, 40 to 50% of the patients with autoimmune adrenocortical insufficiency will eventually develop an autoimmune polyglandular syndrome (APS). Our aim was to characterize a population with primary adrenocortical insufficiency (AI) and determine the prevalence of other autoimmune disorders that might establish the diagnosis of APS.Materials and methods: We included patients with primary AI under surveillance at our Department. Those ...

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

Introduction: Therapy with hydroxychloroquine (HCQ) and chloroquine (CQ) constitutes a rare but documented cause of hypoglycemia in non-diabetic adults. The physiopathological mechanism is not fully understood, and symptoms may appear several years after starting treatment. In this paper, we describe the clinical presentation and investigation of a case of hypoglycemia attributed to HCQ therapy. Clinical Case: A 60-year-old female patient was referred fo...

Introduction: Pituitary tumors can be classified according to their endocrine function, starting from the clinical phenotype to establish a diagnosis. The histological analysis can confirm the clinical suspicion. A thorough classification is essential in the therapeutic approach with an important influence in the disease-free survival.Case report: We report a case of a 16-year-old male, with loss of visual acuity and headache, attended by an Ophthalmolog...

Introduction: Cushing’s disease (CD) is a Grave disease that requires a multidisciplinary and individualized treatment approach.Case report: We describe the case of a 31-years old female patient with Cushing disease diagnosed in 2007. She initially complained of weight fluctuations, amenorrheia, rounded face with plethora and acne, for 1 year duration. Analytically: 0800 h plasma cortisol of 14 μg/dl (5–25) and 2300 h 15 μg/dl, ACTH 1...

Introduction: Type one diabetes is estimated to account for 1% of the pregnancies complicated by diabetes, associated with an increased risk of maternal and perinatal morbidity. The multidisciplinary follow up of the diabetic women can contribute to an improvement of the glycemic control, minimizing the obstetric and perinatal complications.Aims: To characterize pregnant women with type one diabetes followed in our Department’s Endocrinology/Obstetr...