Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1110 | Pituitary and Neuroendocrinology 3 | ECE2019

Isolated central hypothyroidism as a clue for empty sella syndrome

Gouveia Sofia

Introduction: Isolated central hypothyroidism is a rare disease. Acquired causes for central hypothyroidism include iatrogenic, traumatic, immunologic, infiltrative, infectious, vascular or space-occupying lesions. Empty sella may present with endocrine dysfunction, mainly hyperprolactinemia and growth hormone or gonadotropin deficiency. Few cases of empty sella associated with isolated TSH deficiency were published.Case report: A 66-years-old female wit...

ea0056p1005 | Clinical case reports - Thyroid/Others | ECE2018

Pharmacologic interference as a contributory factor for spuriously elevated TSH levels

Gouveia Sofia

Introduction: TRH, thyroid hormones, dopamine, somatostatin and glucocorticoids have a recognized influence on TSH secretion. On the other hand, serotoninergic, histaminergic, catecholaminergic, opioidergic and GABAergic systems establish connections with hypophysiotropic neurons involved in TSH regulation; their relative contribution to TSH secretion is unknown. Still, there are a few reports of H1 receptor antagonists impact on TSH levels.Case report: ...

ea0032p40 | Adrenal cortex | ECE2013

Autoimmune polyglandular syndrome on a cohort of patients with primary adrenocortical insufficiency

Gouveia Sofia , Ribeiro Cristina , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Carrilho Francisco

Introduction: On average, 40 to 50% of the patients with autoimmune adrenocortical insufficiency will eventually develop an autoimmune polyglandular syndrome (APS). Our aim was to characterize a population with primary adrenocortical insufficiency (AI) and determine the prevalence of other autoimmune disorders that might establish the diagnosis of APS.Materials and methods: We included patients with primary AI under surveillance at our Department. Those ...

ea0032p420 | Diabetes | ECE2013

Relationship between metformin treatment and hyperlactacidemia diagnosed at the emergency room

Guelho Daniela , Paiva Isabel , Fonseca Isabel , Gouveia Sofia , Saraiva Joana , Moreno Carolina , Carvalheiro Manuela , Carrilho Francisco

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

ea0032p1136 | Thyroid cancer | ECE2013

Thyroglobulin measurement in fine needle aspirates from cervical lymph nodes

Ribeiro Cristina , Paiva Sandra , Melo Miguel , Gouveia Sofia , Leitao Fatima , Carrilho Francisco

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

ea0022p90 | Bone/Calcium | ECE2010

Primary hyperparathyroidism: retrospective evaluation

Santos Jacinta , Paiva Isabel , Barros Luisa , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

ea0099ep622 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Sometimes It’s Lupus – A Case of Hydroxychloroquine-Induced Hypoglycemia

Rodrigues Gustavo , Monsanto Alice , Carvalho Tania , Ribeiro Cristina , Gouveia Sofia , Rodrigues Dircea , Paiva Isabel

Introduction: Therapy with hydroxychloroquine (HCQ) and chloroquine (CQ) constitutes a rare but documented cause of hypoglycemia in non-diabetic adults. The physiopathological mechanism is not fully understood, and symptoms may appear several years after starting treatment. In this paper, we describe the clinical presentation and investigation of a case of hypoglycemia attributed to HCQ therapy. Clinical Case: A 60-year-old female patient was referred fo...

ea0032p254 | Clinical case reports – Pituitary/Adrenal | ECE2013

Recurrent pituitary tumor: the importance of a functional classification at diagnosis

Moreno Carolina , Paiva Isabel , Gomes Leonor , Ruas Luisa , Gouveia Sofia , Saraiva Joana , Guelho Daniela , Carvalheiro Manuela , Carrilho Francisco

Introduction: Pituitary tumors can be classified according to their endocrine function, starting from the clinical phenotype to establish a diagnosis. The histological analysis can confirm the clinical suspicion. A thorough classification is essential in the therapeutic approach with an important influence in the disease-free survival.Case report: We report a case of a 16-year-old male, with loss of visual acuity and headache, attended by an Ophthalmolog...

ea0032p267 | Clinical case reports – Pituitary/Adrenal | ECE2013

Treatment dilemmas of Cushing disease: case report

Saraiva Joana , Paiva Isabel , Alves Marcia , Gouveia Sofia , Moreno Carolina , Guelho Daniela , Gomes Leonor , Carvalheiro Manuela , Carrilho Francisco

Introduction: Cushing’s disease (CD) is a Grave disease that requires a multidisciplinary and individualized treatment approach.Case report: We describe the case of a 31-years old female patient with Cushing disease diagnosed in 2007. She initially complained of weight fluctuations, amenorrheia, rounded face with plethora and acne, for 1 year duration. Analytically: 0800 h plasma cortisol of 14 μg/dl (5–25) and 2300 h 15 μg/dl, ACTH 1...

ea0032p421 | Diabetes | ECE2013

Type 1 diabetes and pregnancy: importance of glycemic control in maternal and perinatal outcomes

Moreno Carolina , Ruas Luisa , Paiva Sandra , Marta Elvira , Gouveia Sofia , Saraiva Joana , Guelho Daniela , Moura Paulo , Carvalheiro Manuela , Carrilho Francisco

Introduction: Type one diabetes is estimated to account for 1% of the pregnancies complicated by diabetes, associated with an increased risk of maternal and perinatal morbidity. The multidisciplinary follow up of the diabetic women can contribute to an improvement of the glycemic control, minimizing the obstetric and perinatal complications.Aims: To characterize pregnant women with type one diabetes followed in our Department’s Endocrinology/Obstetr...