Endocrine Abstracts

Introduction: Idiopathic hypoparathyroidism is a rare endocrine disorder with varying clinical manifestations ranging from acute hypocalcemic symptoms to asymptomatic soft and skeletal tissue calcifications/ossifications. Patients may present with wide spectrum of rheumatological manifestations, which are under-recognized, thus delaying timely treatment. This results in chronic disability.Case presentation: A 47-year-old male with past history of convuls...

Background: Pituitary carcinoma is extremely rare and constitute only 0.1−0.2% of all pituitary tumors. Diagnosis is on evidence of metastasis, although these criteria has been challenged. Majority of pituitary carcinomas are functioning tumours, usually secreting ACTH (42%) or prolactin (33%). Common sites of metastasis include the brain, spinal cord, leptomeninges, bone, liver, lymph nodes and lung. Mean survival after detection of metastasis is around 1−2 years....

Background: Obesity and related co-morbidities have become an emerging major health concern in South Asia. In addition to the efficacy in weight control, bariatric surgery improves metabolic disorders, thus is a recognized mode of treatment in obesity.Objectives: To review the outcome of metabolic disorders in a group of obese patients in Sri Lanka following bariatric surgery.Methods: Patients who underwent bariatric surgery at Pro...

Background: Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Recovery of pituitary function can occur, and reassessment is required to avoid unnecessary hormonal replacement. However, frequency of re-testing is variable across centres. Aim of this study was to determine recovery rates and time to recovery of hypothalamo-pituitary adrenal (HPA) and thyroid axis after TSA.Methods: We performed a single-centre, retrospecti...

Introduction: The prevalence of gynaecomastia ranges between 40-60% and the majority of cases are asymptomatic, commoner among obese and is due to excess circulating oestrogen. Ovo-testicular disorders of sex development (OT-DSD) is one of the rarest disorders of DSDs and commonly presents with bilateral intra-abdominal gonads and ambiguous external genitalia.Case presentation: A 15 years old male presented with progressively worsening bilateral gynaecom...

Background: Patients receiving radiotherapy for residual or recurrent pituitary adenoma require regular surveillance for the development of anterior pituitary axis deficit. Whilst the sequelae of hypopituitarism post cranial irradiation is well recognized, there are relatively varied incidences of new onset hypopituitarism post-conventional radiotherapy, reported in the literature. We aimed to investigate timing and frequency of the individual axis deficits in adults who have ...

Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Prediction of pituitary function (PF) recovery would inform hormonal replacement strategies. However, the frequency of re-testing of PF is variable across centres. The aim of this study was to determine rates, time and predictors of 6-weeks (6 w) recovery of hypothalamo-pituitary adrenal (HPA) and gonadal function after TSA.Methods: We performed a single-centre, retrospec...

Background: Hypopituitarism can occur post trans-sphenoidal adenomectomy(TSA). Accurate prediction of HPA axis recovery would inform hydrocortisone replacement strategies but there are limited studies on this. In our centre, HPA axis is assessed with pre-operative short synacthen test (SST), day-8 post TSA 9am cortisol and 6-week post-TSA SST. Patients are commenced on hydrocortisone post TSA until 6 weeks review.Methods: We performed a single-centre, lo...