Endocrine Abstracts

Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopau...

Background: Chronic urticaria (CU) is defined as recurrent episodes of hives with or without angioedema of at least 6 weeks’ duration; in almost 40% of the cases an underlying autoimmune process is implicated. Increased prevalence of autoimmune thyroid disease (ATD) has been reported in patients with CU, however the clinical significance of this finding remains controversial. Moreover, data concerning the prevalence of CU in patients with ATD are few.<p class="abstext...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder, associated with mutations of the MEN1 gene, characterised by the combined occurrence of tumours of the parathyroid glands, the pancreatic islet cells and the anterior pituitary.Aim: To identify MEN1 gene mutations and characterize clinical manifestations in Greek patients with MEN1.Patients and methods: We studied 4 ...

Introduction: Systemic mastocytosis (SM) is a rare disorder characterised by clonal proliferation of abnormal mast cells in several tissues, most often skin and bone marrow. Indolent systemic mastocytosis (ISM) is the commonest disease variant in adults, characterised by very low rate of mast cell proliferation. SM has been recognised as a cause of secondary osteoporosis.Objective: To evaluate bone mineral density and fragility fractures in ISM patients....

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism – overt (OH) or subclinical (SUH) – is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...