Endocrine Abstracts

Introduction: Low androgen levels are associated with decreased sexual activity. However, to our knowledge no population based study has evaluated the association between androgen levels and sexual activity in young men.Aim: To evaluate associations between androgen levels and sexual activity in young men.Design: Seven hundred and seventy-three Danish men, aged 20–29 years, underwent clinical and biochemical examination: Total...

Background: PPARγ-agonist treatment may decrease bone mineral density (BMD) in postmenopausal women. The hypothesis that premenopausal women are relatively protected from mineral loss during PPARγ-agonist treatment has not been evaluated in clinical studies.Aim: To investigate the effect of pioglitazone on BMD and bone turnover markers in patients with polycystic ovary syndrome (PCOS).Methods: Thirty premenopausal PCOS pa...

Background: Birth weight has been associated with low bone mass in later life. Previous studies, however, have relied on self-reported data on birth weight, included select populations, or been of a limited size. Moreover, it is unclear if the association between birth weight and bone mass is be mediated by body weight, lean body mass, or fat mass.Aim: We hypothesize that birth weight is associated with peak bone mass in men independent of current lean b...

Objective: To investigate the effect of pioglitazone on cortisol metabolism in PCOS.Design: Thirty insulin resistant PCOS patients were randomized to either 16 weeks of pioglitazone (30 mg/day) or placebo treatment. Before and after intervention, patients underwent 24 h 20 min.-integrated blood sampling for measurement of cortisol and 24 h excretion of cortisol, cortisone and steroid metabolites (cortisol, corticosteron, androgen, and 17-hydroxyprogester...