Searchable abstracts of presentations at key conferences in endocrinology

ea0014p318 | (1) | ECE2007

Carbamazepine and risk of hypothyroidism: a prospective study

Horacek Jiri , Simko Julius , Waberzinek Gerhard

While carbamazepine (CBZ) treatment may affect serum thyroid hormone concentrations it rarely leads to clinically important hypothyroidism. This study was aimed to evaluate an early effect of CBZ on thyroid status in hypothyroid patients with thyroid hormone replacement, as compared with patients without a thyroid disorder.Twenty-nine patients indicated for CBZ treatment were followed prospectively. Their thyrotropin (TSH), total thyroxine (TT4) and free...

ea0063p1203 | Thyroid 3 | ECE2019

Raynaud’s phenomenon as a primary symptom of the thyroid carcinoma

Havlinova Barbora , Horacek Jiri , Gabalec Filip , Cap Jan

Paraneoplastic manifestations of well-differentiated thyroid carcinoma are not so common but they can be the first signal of cancer. We present a case of a man with Raynaud’s phenomenon in the area of the lower limb fingers. Clinical signs of Raynaud’s phenomenon with ulceration and gangrene of fingers of both lower limbs appeared several months before the diagnosis of papillary microcarcinoma of the thyroid was made. The diagnosis of carcinoma of the thyroid was det...

ea0037ep950 | Thyroid (non-cancer) | ECE2015

Radioiodine treatment of Graves' disease: dose–response analysis

Cepkova Jitka , Svilias Ioannis , Krcalova Eva , Horacek Jiri

Introduction: Despite more than 60 years’ experience with radioactive iodine 131I (RAI) treatment of Graves’ disease (GD) about the most appropriate dosing regime is still controversial. The objective of our research was to analyse the outcome of RAI therapy in our cohort of patients.Methods: Retrospectively, we analysed 603 patients with GD (500 women and 103 men, mean age 51.5±12.7 years) treated with RAI. According to recomme...

ea0070aep929 | Thyroid | ECE2020

No important salivary gland damage following radioiodine remnant ablation

Krcalova Eva , Horacek Jiri , Gabalec Filip , Zak Pavel , Dolezal Jiri

Radioiodine (131I, RAI) has traditionally been used in thyroid cancer treatment but its benefitshould be balanced against possible risks. Among them, salivary gland dysfunction has oftenbeen discussed, although the reported data have been inconsistent. While some authors reported functional changes following higher (mostly cumulative) activities, there have been scarce data on the activity of 3.7 GBq (100 mCi) that is most commonly used for RAI remnant ablation...

ea0026p734 | Diabetes (epidemiology, pathophysiology) | ECE2011

Does anxiety influence food preference and insulin resistance in healthy men?

Brunerova Ludmila , Potockova Jana , Horacek Jiri , Andel Michal

Introduction: We tested our hypotheses that higher anxiety/depression scores can be connected with food preference of carbohydrates and higher insulin resistance.Methods: We examined 42 healthy men (average age 43.5±7.4 years, average BMI 27.4±5.7 kg/m2). Study protocol included filling in the self-asssessing scores of anxiety (SAS) resp. depression (SDS), carbohydrate-craving questionnaire (CCQ); assessment of 3-days diet records, h...

ea0022p633 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Relationship between metabolic parameters and central dopaminergic activity in healthy men

Brunerova Ludmila , Horacek Jiri , Potockova Jana , Andel Michal

Background: Dopaminergic agonists have been proved to improve control of diabetes and lipids. Central dopaminergic activity can be measured by apomorphin test (apomorphin increases GH and decreases prolactin levels, which is a marker of dopaminergic activity).The aim of our study was to evaluate the relationship between central dopaminergic activity and metabolic parameters in healthy men.Methods: We examined 42 healthy men (averag...

ea0014p520 | (1) | ECE2007

Food preference, central serotoninergic activity, depression and insulin resistance in obese and lean healthy men: a pilot study

Brunerova Ludmila , Potockova Jana , Horacek Jiri , Andel Michal

Objective: Higher anxiety/depression scores can be connected with food preference of carbohydrates, with increased insulin secretion and thus can lead to insulin resistance. Three hypotheses were postulated: 1. more depressive (still in the normal range) subjects do not differ in the central serotoninergic activity from those less depressive. 2. the former do not differ in food preference and 3. in insulin resistance from the latter.Methods: healthy men,...

ea0073ep17 | Adrenal and Cardiovascular Endocrinology | ECE2021

Biopsy in the diagnosis of bilateral pheochromocytoma

Havlinova Barbora , Mosnerova Eliska , Gabalec Filip , Horacek Jiri , Cap Jan

Pheochromocytoma is a rare neuroendocrine tumour usually formed in the adrenal medulla. Percutaneous biopsy has been associated with life-threatening haemorrhage, hypertensive crisis, capsular disruption with tumour implantation and death. We present a case of a 63 years old woman with non-specific clinical signs which included high blood pressure, headache, tachycardia and abdominal pain. She was treated for rheumatoid arthritis. Bilateral expansion of adrenal gland with dela...

ea0081p426 | Pituitary and Neuroendocrinology | ECE2022

3P syndrome: pheochromocytoma, paraganglioma, pituitary adenoma

Havlinova Barbora , Gabalec Filip , Solař Miroslav , Horacek Jiri , Cap Jan

Neuroendocrine tumours, especially pheochromocytomas, paragangliomas and pituitary adenomas, are more common in younger patients in 3rd–5th decade of life. PitNETs are the most common intracranial tumours, while PHEO and PGL are rare. The hormonal activity, signs and symptoms of NET are variable. PGL, PHEO and PitNET in one patient remains an exceptional association. 72 cases of concomitant pituitary adenoma and PGL have been reported to date. The first record of a patien...

ea0041ep315 | Clinical case reports - Pituitary/Adrenal | ECE2016

Posture-responsive primary aldosteronism – the utility of seated saline suppression test

Jakubikova Iva , Horacek Jiri , Spitalnikova Sylvie , Ballon Marek , Lojik Miroslav , Gabalec Filip , Zak Pavel

Introduction: The diagnostic procedure of primary aldosteronism (PA) includes one of four confirmatory tests, of which the saline suppression test (SST) seems to be the most convenient one. Current guidelines recommend SST to be performed in a recumbent position. However, a recent preliminary study demonstrated a higher sensitivity of SST when performed in the upright (i.e. seated) position. Here, we report a case of posture-responsive PA with a negative recumbent SST but clea...