Endocrine Abstracts

Matrix-GLA-protein (MGP) was repeatedly associated with inflammation markers during the last decade. It is expressed in leucocytes and is a regulator of immune response. Due to posttranslational modification, there are 4 forms. The form responsible for immunomodulation is still unknown. Since the predicted active form - carboxylated, phosphorylated MGP - is not directly associated with immunomodulation, we aimed to investigate the association of dp-ucMGP (dephosphorylated, unc...

Background: Anti-Müllerian hormone (AMH) is well known for its association with ovarian follicular count and ovarian reserve in general as well as for its recruitment of primordial follicles in women. With an explicit decrease in menopause, it is mainly used for clinical questions from in-vitro-fertilisation to polycystic ovary syndrome. Interestingly, AMH levels in men are quite high during lifetime, but there is only few data about its relevance and potential effects in...

Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male popu...

Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly ...

Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly ...