Searchable abstracts of presentations at key conferences in endocrinology

ea0022p763 | Thyroid | ECE2010

Effect of hyperthyroidism on parameters of oxidative stress and antioxidant status in Wistar rats

Petrulea Mirela Sanda , Duncea Ileana , Muresan Adriana

Introduction: Thyroid hormones are the most important factors involved in the regulation of the basal metabolic state, as well as in the oxidative metabolism. Oxidative stress accompanying hyperthyroidism is caused by increased synthesis of reactive oxygen species (ROS) and changes in the antioxidant defence system.Aim of the study: To evaluate the pro-oxidant/antioxidant status and the effect of vitamin E supplementation in damage caused by the excessiv...

ea0016p735 | Thyroid | ECE2008

Onset of thyrotoxicosis in patients over 65 years is associated with increased risk of skeletal and heart disease

Duncea Ileana , Georgescu Carmen , Ilie Ioana

It has been shown that aging is associated with ‘physiological’ alterations in both the hypothalamo–pituitary–thyroid axis and at the peripheral level such as elevation of basal TSH levels, often with normal T3 and T4 levels and decreased nuclear binding of thyroid hormones, particularly of T3. The frequency of nodular goiter and of an altered thyroid status increases with advancing age. The aim of our study was to analyze t...

ea0014p402 | (1) | ECE2007

Marginal periodontal pathology in patients with pituitary disorders

Duncea Ileana , Georgescu Carmen , Duncea Ioana

Periodontal changes are induced by hormonal alterations through soft tissue oedema, inflammation, demineralization or abnormal periosteal development of the alveolar bones.Objectives: The purpose of the present work was to evaluate the frequency, severity and type of periodontal disease in subjects with previously diagnosed and non-treated pituitary disorders.Patients and methods: Twenty-five subjects (21 women and 4 men) aged 44.7...

ea0020p78 | Thyroid | ECE2009

Value of ultrasound elastography of the thyroid gland in differentiating malignant nodules

Ghervan Cristina , Dumitriu Dana , Dudea Sorin , Muntean Valentin , Duncea Ileana

Background and objective: One of the key features of thyroid gland cancer evaluated at palpation is the degree of firmness: malignant lesions tend to be much harder than benign ones. US elastography is combining the diagnostic advantages of high-frequency US examination and the accuracy of thyroid cancer diagnosis based on the lesion’s stiffness. The aim of our prospective study was to evaluate the elastographic appearance of thyroid gland tumours and to explore the sensi...

ea0020p165 | Thyroid | ECE2009

New clinical feature in hypothyroidism: paroxysmal supraventricular tachycardia: case report

Olarescu Cristina , Ghervan Cristina , Hazi Georgeta , Duncea Ileana

Background: The aim of this case report is to underline the possible etiological link between paroxysmal supraventricular tachycardia (PSVT) and hypothyroidism, although supraventricular arrhythmias are ordinary features of hyperthyroidism. We present the case of a patient with repetitive episodes of PSVT whose autoimmune hypothyroidism was diagnosed and thyroxin replacement therapy leaded to remission of arrhythmia.Methods: A 47 year old women with a lo...

ea0020p289 | Clinical case reports and clinical reports | ECE2009

Glucocorticoid resistance syndrome: treatment with ketoconazole, an efficient therapy solution – case report

Molnar Erika-Emoke , Ghervan Cristina , Hazi Georgeta , Duncea Ileana

Background: Glucocorticoid resistance syndrome is a rare, familial or sporadic disease, caused by genetic mutations of the glucocorticoid receptor or at any other level of the signaling pathway. It is characterized by general, partial, target-tissue insensitivity to glucocorticoids, leading to activation of the hypothalamo–hypophysis–adrenal axis resulting in compensatory increased levels of cortisol, but also increased concentrations of adrenal products with mineral...

ea0014p580 | (1) | ECE2007

The empty sella syndrome – particularities of the clinical features depending on etiology

Ghervan Cristina , Olarescu Cristina , Leucuta Daniel , Duncea Ileana

The empty sella syndrome (ESS) is caused by the herniation of the suprarahnoidian space into the sella turcica, generating the compression of the pituitary gland and, in most cases, a remodelling of the sella. The purpose of this study was to evaluate the etiology, the degree of hormonal deficit and the occurrence rate of the signs and symptoms accompanying ESS.Material and methods: We performed a descriptive, retrospective study by analysing the medical...

ea0037ep1090 | Endocrine tumours | ECE2015

Benign and malignant thyroid disease in patients with acromegaly

Tenu Irina , Kiraly Antonia , Duncea Ileana , Valea Ana , Silaghi Alina , Ghervan Cristina

Introduction and purpose: Acromegaly is characterised by a chronic increase of GH and IGF-1 levels that may induce various clinical symptoms and multisystem comorbidities. The purpose of this study is to evaluate the type and frequency of thyroid disease most often associated with acromegaly patients.Material and methods: We conducted a retrospective observational study analysing the data from the observation charts of 77 patients with acromegaly (58 fem...

ea0032p278 | Clinical case reports - Thyroid / Others | ECE2013

Coexistence of euthyroid ophthalmopathy and isolated ocular myasthenia gravis in a patient with vitiligo: a challenging diagnosis of APS-3C

Duncea Ileana , Ilie Ioana R , Goia-Socol Monica , Gherghel Dana , Georgescu Carmen E

About 1% of the patients with Graves’ disease develop myasthenia gravis, however, euthyroid Graves’ ophtalmopathy has only rarely been associated with myasthenia gravis and especially with isolated ocular myasthenia gravis. A 63-year old, male patient with vitiligo presented double vision and right ptosis, shortly followed by left ptosis. On the ophthalmological examination there was bilateral ptosis and orbito-ocular ultrasonography yielded a thickening of the left ...

ea0032p1037 | Thyroid (non-cancer) | ECE2013

Sexual dysfunction in women with thyroid pathology

Ana Valea , Cristina Ghervan , Alina Silaghi , Iulia Iacob , Florica Tomesc , Adina Terec , Ileana Duncea

Introduction: Sexual dysfunction is a particular pathology with relative high prevalence, often underestimated in general population. It’s manifest as an impairment of sexual desire, orgasm, sexual excitement or pain related to intercourse. Although often recognize a psychogenic cause, sexual dysfunction are found also in various systemic diseases more or less related to changes of sexual hormones. Thyroid pathology, particularly hyper and hypothyroidism, with high freque...