Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp68 | Reproductive Axis | ECE2019

DHT, rather than free testosterone, influences symptoms of aging in eugonadal men

Sansone Andrea , Kliesch Sabine , Tuttelmann Frank , Dugas Martin , Isidori Andrea M. , Schlatt Stefan , Zitzmann Michael

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

ea0044p25 | Adrenal and Steroids | SFEBES2016

Random spot urinary metanephrines compared to 24-h collection in the diagnosis and follow up of phaeochromocytomas and paragangliomas: preliminary results

Sbardella Emilia , Isidori Andrea M , Shine Brian , Jafar-Mohammadi Bahram , Grossman Ashley B

Introduction: Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours with high morbidity. The majority are benign and surgically curable, but genetic testing suggests that many are associated with germline mutations, and careful long-term follow-up of patients and their family members is important. Regular biochemical screening with plasma or urinary metanephrines (uMetanephrines) is essential, but currently 24-h collections of uMetanephrines is cumbersome and inconven...

ea0044p149 | Neuroendocrinology and pituitary | SFEBES2016

Pituitary stalk thickening: use of an innovative MRI analysis to guide clinical management

Sbardella Emilia , Joseph Robin N , Jafar-Mohammadi Bahram , Isidori Andrea M , Cudlip Simon , Grossman Ashley B

Context: Disease processes that affect the pituitary stalk are broad, ranging from indolent lesions requiring simple observation to severe lesions with significant implications. Diagnosis and management of these lesions remains unclear.Objective: The aim of this study was to assess the clinical presentation, biochemical and pathology characteristics of pituitary stalk thickening lesions and their association with specific MRI features in order to provide...

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0020p48 | Adrenal | ECE2009

Cannabinoids and regulation of adipogenesis in differentiating 3t3-l1 preadipocytes

Isidori Andrea M , Lolli Francesca , Pierotti Silvia , Pozza Carlotta , Bonifacio Vincenzo , Gandini Loredana , Lenzi Andrea

Objective: Endocannabinoids (CBs) are novel lipid mediators that modulate appetitive behaviour and energy metabolism. The overactivation of the endocannabinoid system plays an important role in obesity. Endocannabinoids may regulate the lipid metabolism through their receptors (CB1 and CB2) in liver and adipose tissue. 11β-hydroxysteroid dehydrogenase (11β-HSD1) type 1 regulates the local availability of active glucocorticoid, potent inductors of adipogenic different...

ea0016oc3.5 | Diabetes and obesity | ECE2008

Hormonal regulation of 11-β-HSD1 expression and activity in differentiated 3T3- L1 adipocytes

Pierotti Silvia , Lolli Francesca , Gianfrilli Daniele , Bonifacio Vincenzo , Gandini Loredana , Lenzi Andrea , Isidori Andrea M

Introduction: In humans, testosterone treatment affects body fat distribution and metabolism. The mechanisms involved in these processes are not yet fully understood. We investigated whether sex hormones modulate the expression and activity of type1 11-β-hydroxy-steroid-dehydrogenase (11β-HSD1). 11β-HSD1 catalyses the conversion of inactive cortisone into active cortisol, a key step for the development of functional adipocytes. Based on previous studies an inhib...

ea0065p242 | Metabolism and Obesity | SFEBES2019

Glucocorticoid treatment is associated with dose-dependent effects in healthy male volunteers

Pofi Riccardo , Bonaventura Ilaria , Othonos Nanthia , Marjot Thomas , Moolla Ahmed , Isidori Andrea M , Hodson Leanne , Tomlinson Jeremy W

Objective: 2–3% of the population of the UK receive glucocorticoid (GC) therapy. Significant adverse effects are not confined to chronic use: recurrent short-course administration is associated with increased morbidity and mortality. Data about the cumulative dose responsible for drawbacks during GC treatment are still lacking. The aim of this study was to test the impact of 7 days of 10 or 15 mg of Prednisolone on metabolism in healthy male volunteers.<p class="abste...

ea0067o55 | Oral Presentations | EYES2019

Glucocorticoid treatment is associated with dose-dependent insulin resistance in healthy male volunteers

Pofi Riccardo , Bonaventura Ilaria , Othonos Nanthia , Marjot Thomas , Moolla Ahmed , Isidori Andrea M , Hodson Leanne , Tomlinson Jeremy W

Objective: Currently, 2–3% of the population of the UK and US receive glucocorticoid (GC) therapy. Significant adverse effects are not confined to chronic use; recurrent short-course administration is associated with increased morbidity and mortality. The efficacy of GC therapy is not in doubt but data about the cumulative dose responsible for adverse effects during GC treatment are still lacking. The aim of this study was to test the impact of 7 days of 10 or 15 mg of Pr...

ea0063p453 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Risk factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a case-control study from NETTARE Unit

Feola Tiziana , Sesti Franz , Puliani Giulia , Sbardella Emilia , Cozzolino Alessia , Lenzi Andrea , Faggiano Antongiulio , Isidori Andrea M , Giannetta Elisa

Introduction: GEP-NENs represent a heterogeneous group of neoplasms with increasing incidence in the last years. Pathogenesis and risk factors of sporadic GEP-NENs are not clear and still debated. The aim of this study is to evaluate the main risk factors for sporadic GEP-NENs in patients followed by the NETTARE Unit (NeuroEndocrine TAsk force of of ‘Sapienza’ University of Rome).Methods: We performed a case-control study including 32 consecuti...

ea0049gp149 | Male Reproduction and Endocrine Disruptors | ECE2017

Presentation, clinical features and long-term follow-up of Leydig cell tumours of the testis: 77 cases from a single center experience

Isidori Andrea M. , Giannetta Vincenzo , Gianfrilli Daniele , Lauretta Rosa , Tarsitano Maria Grazia , Fattorini Giorgio , Pofi Riccardo , Pozza Carlotta , Lenzi Andrea

Introduction: With the improved imaging techniques, Leydig cell tumours (LCTs) are frequently found, accounting up to 22% of testicular tumours. The natural history of LCTs is relatively unknown, because of the small size and heterogeneity of available studies. Since LCTs are often removed, long-term follow-up is missing. The aim of this study was to report the experience with a large cohort of prospectively collected LCTs.Materials and methods: Patients...