Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp45 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Hypoglycemia and dementia risk in older patients with type 2 diabetes: a propensity-score matched analysis of a population-based cohort study

Jin Han Seung , Kim Young-Gun , Young Moon So

Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM.Methods: We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 7,752 patients who had ever experienced hypo...

ea0090p335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Dapagliflozin Improves Glycemic control and Liver Function with Body Weight Loss as Add-on therapy to Metformin Plus Evogliptin: A 24-week, Randomized, Double-blind, Clinical Trial

Jeong In-Kyung , Mook Choi Kyung , Ah Han Kyung , Kim Kyoung-Ah , kim injoo , jin Han Seung , Wan Lee Byung , Lee Won-Young , Jib Yoo Soon

Background and aims: The efficacy and safety of dapagliflozin as add-on therapy in patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control with evogliptin and metformin combinations was investigated.Materials and methods: Patients with HbA1c of 7.0% to 10.5% receiving evogliptin 5mg and metformin ≥1000 mg were randomized to receive dapagliflozin 10 mg/day (n=99) or placebo (n=99) for 24 weeks. The primary end...

ea0081p66 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of empagliflozin in palmitate-induced ER stress and apoptosis in H9C2 cells

Jeong Jae Yeop , Choi Sung-E , Song Min Woo , Ho Park Suck , Kang Yup , Ho Kim Tae , Ahn So-Yeon , Jin Kim Hae , jin Han Seung , Jeon Ja Young , Lee Nami , Jung Kim Dae , Lee Kwan-Woo

Aim/hypotheses: Ectopic lipid accumulation in the heart contributes to the abnormal function of the heart and to the death of cardiomyocytes. Saturated FFA is one of the most important causes of death in cardiomyocytes. Although empagliflozin has been reported to be beneficial for people with diabetic complications and/or CVD, it has not been confirmed as to how it affects cardiomyocytes death by FFA. This study was designed to evaluate the protective effects of SGLT2 inhibito...

ea0081ep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of deferoxamine (DFO) in insulin resistance and diabetes

Ahn So-Yeon , Woo Song Min , Yeop Jeong Jae , Ho Kim Tae , Choi Sung-E , Kang Yup , Jin Kim Hae , Young Jeon Ja , JIN Han Seung , Lee Nami , Lee Kwan-Woo

Iron also plays an important role in many physiological processes, including redox balance, inflammation, and metabolism. It is reported perturbation of iron (Fe) homeostasis has also been associated with metabolic diseases. Iron reduction, with iron chelator, has preventive effects in cardiovascular remodeling and obesity. On the other hand, deferoxamine (DFO) increases hypoxia and collagen production in the kidney. Thus, the effects of DFO on metabolic disease remains contro...