Endocrine Abstracts

Data regarding hyperthyroidism is lacking in Nepal. We did a retrospective analysis of clinical profile and treatment modalities of hyperthyroidism patients in our center.Methodology: Retrospective data of 132 hyperthyroidism patients between March 2013 and April 2014 at Kathmandu Diabetes and Thyroid Center were analyzed. These patients’ records were followed up for one year.Results: Hyperthyroidism was common in females (73....

Nepal seems to have high thyroid disorder prevalence but there has been no prevalence studies done so far in general population. We do have a few hospital based prevalence studies of hypothyroidism in Nepal. Our study aims to find the prevalence of thyroid disorders in general population in Nepal.Methods: We did thyroid function tests of the general population through screening camps in different parts of Nepal. We screened people from 7 places in 5 dist...

Introduction: The association between type 2 diabetes mellitus and obesity is very close. Obesity is common in women aged between 45 and 49 years. Prevalence of prediabetes, i.e. impaired fasting glucose also seems to be higher in women than men in the Indian population. The present work is planned to study the prediabetic status in preobese and obese in pre- and post-menopausal women with the help of estimation of fasting blood glucose (FBG) levels.Mate...

A 55-year-old lady presented with visual deterioration of 2 years duration affecting both eyes. Initial examination demonstrated reduced visual acuity in the LE at finger perception and RE 6/9 with right temporal superior quadrantopia. Rest of the systemic examination was unremarkable. Relevant endocrine tests revealed a FSH-146.9 U/l and FT4-14 pmol/l. MRI pituitary demonstrated a pituitary adenoma with significant suprasellar component compressing the optic nerves...

Introduction: Children with pseudohypoparathyroidism (PHP) can have a broad range of phenotypic features and biochemical abnormalities. The heterogeneity of this patient group prompted us to review the clinical features of these children in our service.Methods: We recorded the mode of presentation, clinical features, growth pattern, biochemical profile and progress of 13 paediatric patients with PHP and hypocalcaemia under review in our service over a 11...

Background: Hyperprolactinemia is a common endocrine disorder. Yet, data on clinical profile of Nepalese patients with hyperprolactinemia is missing. The aim of this study was to assess the clinical profile of Nepalese patients with hyperprolactinemia.Methodology: Retrospective clinic based study conducted at the endocrine centre Kathmandu Diabetes and Thyroid Center, Lalitpur, Nepal, in which data was collected from the patient record files of the subje...

Case history: We have previously presented the case of a 31 year lady presenting with a seizure following exercise with a blood sugar of 1.4 mmol/l on a background of an 8 month history of episodic slurred speech, blurred vision and hunger relieved by eating in 2011.Investigations: Investigations confirmed an insulinoma and imaging, including Ga68 DOTATATE PET CT identified a lesion in the tail of the pancreas with multiple liver metastases. M...

Autosomal Dominant Hypocalcaemia (ADH) type 1 is caused by activating mutations of the calcium-sensing receptor (CaSR) gene. Although a rare condition, the exact prevalence is uncertain as patients are asymptomatic and, historically, were sometimes diagnosed with hypoparathyroidism (HPT) due insensitivity of earlier PTH assays and failure to check urinary calcium. The consequences of an erroneous diagnosis of HPT in patients with ADH can be profound, as treatment with calcium ...

Homocystinuria is a rare autosomal recessive disorder of the transsulfuration or methylation pathway in methionine metabolism.We present a case of a 25 years old female, who presented with rapid onset loss of vision in both eyes and short-sightedness. She had a background of well-controlled epilepsy, normal mental and physical development. She had no family history of Marfan’s syndrome.On examinatio...

Homocystinuria is a rare autosomal recessive disorder of the transsulfuration or methylation pathway in methionine metabolism.We present a case of a 25 years old female, who presented with rapid onset loss of vision in both eyes and short-sightedness. She had a background of well-controlled epilepsy, normal mental and physical development. She had no family history of Marfan’s syndrome.On examinatio...