Searchable abstracts of presentations at key conferences in endocrinology

ea0090p130 | Pituitary and Neuroendocrinology | ECE2023

Increased Plasma Leptin and Agouti-Related Peptide May Be Related To Sleep Alterations In Patients With Active Cushing’s Syndrome

Sulu Cem , Mefkure Ozkaya Hande , Kadioglu Pinar

Aim: To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) leptin, and interleukin-6 (IL-6) play a permissive role in sleep alterations.Methods: We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyses of AgRP, leptin, and IL-6. The laboratory and sleep-related pa...

ea0090p159 | Pituitary and Neuroendocrinology | ECE2023

Mild Autonomous Cortisol Secretion May Be Related To Decreased Thalamic Volume

Sulu Cem , Kadioglu Pinar , Mefkure Ozkaya Hande

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

ea0090ep774 | Pituitary and Neuroendocrinology | ECE2023

The role of artificial intelligence algorithm in predicting the prognosis in prolactinomas

Kara Zehra , Sulu Cem , Demir Ahmet Numan , Kadioglu Pinar

Objective: To test the utility of the artificial learning algorithms using magnetic resonance (MR) images of the pituitary gland in predicting the prognosis of prolactinoma.Methods: This single-center, retrospective study was conducted in the Pituitary Center of a tertiary care university hospital. A total of 224 images derived from 38 patients with treatment-refractory prolactinoma, 23 patients with prolactinoma remission and 51 healthy individuals were...

ea0035p869 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

A case with acromegaloidism

Kadioglu Pinar , Kalfa Melike , Hatipoglu Esra , Gundogdu Sadi

Introduction: Acromegaloidism is characterized by features of acromegaly without excessive GH secretion.Case report: A 24-year-old male presented with acral enlargement and bilateral non-inflammatory wrist and ankle pain. He had coarse facial features, prominent clubbing, enlarged hands and feet. BMI was 21.3 kg/m2. He did not have a relevant personal and family history. He was not on any medication. Due to his acromegaloid appearance he was r...

ea0026p97 | Female reproduction | ECE2011

Sexual dysfunction in polycystic ovary syndrome

Velet Selvinaz , Velet Mustafa , Kadioglu Pinar , Sahmay Sezai

Objective: We aimed to examine sexual dysfunction frequency and relationship between sexual dysfunction and androgen level in polycystic ovary syndrome.Patients and methods: Twenty-five PCOS patients were recruited from the outpatient clinics of the Division of Endocrinology in the Department of Internal Medicine and outpatient clinics of the Department Obstetrics and Gynecology at the Cerrahpasa Medical Faculty. Twenty-five healthy volunteer age and sex...

ea0014p330 | (1) | ECE2007

Thyroid disease prevalance in Cushing’s disease

Toptas Tayfur , Tiryakioglu Ozay , Yetkin Demet Ozgil , Kadioglu Pinar

Purpose: To determine the prevalence of nodular thyroid disease, autoimmune thyroid disease, goiter and primary thyroid dysfunction in patients with active Cushing’s disease.Patients and methods: Nineteen patients with active Cushing’s disease (17 female, 2 male, mean age 43.16±3.55 years) and forty, age and gender matched healthy volunteers who served as the control group (34 female, 6 male, mean age 47.28±2.31 years) were included i...

ea0099p520 | Pituitary and Neuroendocrinology | ECE2024

Use of artificial intelligence to predict survival of patients with acromegaly: is it really better?

Sulu Cem , Sahin Serdar , Ozkaya Hande , Kadioglu Pinar

Aim: To identify the causes and predictors of mortality in acromegaly patients diagnosed, treated, and followed in the Pituitary Center of Istanbul University-Cerrahpasa over the last three decades using machine learning (ML) models.Methods: The study sample consisted of 607 consecutive patients diagnosed with acromegaly at Cerrahpasa Faculty of Medicine during the period 1990 – 2023. The main inclusion criteria were age > 18 years and a clear-c...

ea0099p533 | Pituitary and Neuroendocrinology | ECE2024

The relations between serum growth hormone, seminal plasma growth hormone, and sperm count in acromegaly patients

Cicek Ebru , Sulu Cem , Sahin Serdar , Ozkara Hamdi , Ozkaya Hande , Pivonello Rosario , Kadioglu Pinar

Aim: To investigate the relationship between serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels, seminal plasma GH and IGF-1 levels, and sperm parameters in acromegalic patients.Methods: A cross-sectional study was conducted on 24 acromegaly patients (acromegaly group), 11 non-functioning adenoma (NFA) patients (NFA group), and 16 healthy men (control group). Seminal plasma GH and IGF-1 levels were measured. Semen parameters and se...

ea0090p266 | Late-Breaking | ECE2023

Risk of Impulse Control Disorders in Cabergoline-Treated Cushing’s Disease: A Cross-sectional Study

Sulu Cem , Gul Nurdan , Ciftci Sema , Tanrikulu Seher , Yener Ozturk Feyza , Mefkure Ozkaya Hande , Cagri Poyraz Burc , Kadioglu Pinar

Aim: To determine the prevalence of impulse control disorder (ICD) in patients with Cushing’s disease (CD) treated with cabergoline (CBG) compared to CBG-naive patients with CD.Methods: We performed a cross-sectional study in patients with CD followed at 5 referral centers based in Istanbul. Eligible patients with CD were those with current CBG treatment for ≥ 3 months. Eligible controls were CBG-naive patients with CD that were matched for ag...

ea0056p798 | Pituitary - Clinical | ECE2018

Static and dynamic balances in acromegaly and impact of exercise on balance

Haliloglu Ozlem , Topsakal Nuri , Camliguney Filiz , Polat Korkmaz Ozge , Sahin Serdar , Cotuk Birol , Kadioglu Pinar , Erkut Oya

Purpose: Patients with acromegaly may have changes in balance due to visual disturbances, musculoskeletal abnormalities and changes in body composition. We aim to compare static and dynamic balances in patients with acromegaly and healthy controls and to evaluate effects of exercise on balance in patients with acromegaly.Methods: Twenty-two patients with acromegaly followed at the Endocrinology Outpatient Clinic of Istanbul University, Cerrahpasa Medical...