Searchable abstracts of presentations at key conferences in endocrinology

ea0049s18.2 | Hyperandrogenism: challenges in clinical management | ECE2017

Metabolic perspectives for the non-classical CAH (NCAH)

Kelestimur Fahrettin

Congenital adrenal hyperplasia (CAH) is one of the most common autosomal recessive inherited endocrine diseases and is characterized by complete or partial impairment of adrenal steroidogenesis. 21-hydroxylase deficiency and 11β-hydroxylase deficiency account for 90% and 6–8% of cases of CAH, respectively. NCAH is the mild form of CAH and occurs in approximately 0.1–0.2% in the general population. The worldwide prevalence of NCAH among hyperandrogenic women is a...

ea0032p605 | Female reproduction | ECE2013

Ovarian functions and polycystic ovary syndrome in women with type 1 diabetes mellitus

Karaca Zuleyha , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Background: Type 1 DM has been shown to be associated with increased rate of hyperandrogenemia, polycystic ovarian changes (PCO) and PCOS. Although stimulated 17-OH progesterone responses to leuprolide has previously been shown to be increased in pubertal girls with type 1 DM, the effect of gonadotropin releasing hormone analog stimulation has not been studied in adult women.Materials and methods: Fifty-two adult women with type 1 DM and 15 healthy adult...

ea0016p609 | Reproduction | ECE2008

A comparison between flutamide and finasteride plus flutamide combination in the treatment of hirsutism

Unluhizarci Kursad , Ozel Demet , Tanriverdi Fatih , Karaca Zuleyha , Kelestimur Fahrettin

Objective: To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with moderate to severe hirsutism.Patients and methods: Thirty hirsute women were randomly assigned to two treatment groups. Sixteen patients (group 1) were treated with flutamide (125 mg per day) and 14 patients (group 2) were treated with finasteride (5 mg per day) plus flutamide (125 mg per day) f...

ea0056p808 | Pituitary - Clinical | ECE2018

The comparison of combination test either with 1 μg acth test and glucagon test for the evaluation of hypothalamo-pituitary-adrenal axis in patients with pituitary disorders

Unluhizarci Kursad , Kokoglu Emel , Karaca Zuleyha , Tanriverdi Fatih , Kelestimur Fahrettin

The low-dose (1 μg) ACTH stimulation test or glucagon stimulation test (GST) are candidate tests for hypothalamo-pituitary-adrenal (HPA) axis evaluation in patients with pituitary disorders. In this study, we aimed to compare the combination of low-dose ACTH and GSTs (named as combination test) with each test results alone in the evaluation of HPA axis in patients with pituitary disorders whether combination test may overcome the problems when the test results are equivoc...

ea0063p739 | Pituitary and Neuroendocrinology 2 | ECE2019

Investigation of the role of miR-126-3p in pituitary insufficiency following traumatic brain injury

Tufan Esra , Taheri Serpil , Karaca Zuleyha , Bayramov Kezban Korkmaz , Unluhizarci Kursad , Kelestimur Fahrettin

Aim: Traumatic brain injury (TBI) is known to be associated with pituitary insufficiency (PI). We have recently shown that there was a relationship between miR-126-3p, miR-3610 and PI developing in follow up of patients with TBI. In this study, we aimed to test the effects of miR-126-3p on hypothalamus pituitary-adrenal (HPA) and Growth hormone-Insulin like growth factor (GH-IGF-1) axes.Materials and methods: miR126-3p microinjection was performed to mou...

ea0049ep1129 | Female Reproduction | ECE2017

NCAH prevalance with novel CYP21A2 and CYP11B1 mutations in hirsut turkish women

Polat Seher , Karaburgu Sulbiye , Unluhizarci Kursad , Dundar Munis , Ozkul Yusuf , Karaca Zuleyha , Kelestimur Fahrettin

Introduction: Hirsutism affects 5–8% of the whole female population. In most patients, hirsutism is associated with hyperandrogenemia and the most common cause of androgen excess is polycystic ovary syndrome; however, the clinical presentation of non-classical congenital adrenal hyperplasia(NCAH) in females is often indistinguishable from other hyperandrogenic disorders because of common clinical signs with hirsutism and poly cystic ovary syndrome(PCOS).<p class="abst...

ea0041gp22 | Adrenal (2) | ECE2016

Clinical and polysomnographical evaluation of sleep in patients with Cushing’s syndrome

Ismailogullari Sevda , Firat Sedat Tarik , Karaca Zuleyha , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Patients with Cushing’s Syndrome (CS) frequently have sleep complaints. The aim of the study was to evaluate the prevalance sleep disturbances and sleep structure of patients with CS.Materials and methods: 33 patients with CS were evaluated both clinically and with polysomnograhy (PSG) findings in terms of sleep disorders and data were compared with 20 healthy controls.Results: Seventeen (51.1%) patients with CS ...

ea0041ep400b | Developmental endocrinology | ECE2016

Mouse paternal-RNAs initiate pattern of metabolic disorders in a strain dependent manner

Basaran Guzide Satir , Akbarova Yagut , Korkmaz Kezban , Unluhizarci Kursad , Cuzin Francois , Kelestimur Fahrettin , Rassoulzadegan Minoo

Several instances of RNA-mediated inheritance of phenotypic variation have been reported, among them metabolic disorders. We and others have observed that microinjection into naive fertilized mouse eggs of total sperm RNAs of obese and diabetic males maintained on high-fat diet induce the same pathological variation in the offspring. A role of noncoding RNAs is currently the prevailing hypothesis.The sperm RNA content is complex. It depends on environmen...

ea0041ep898 | Pituitary - Clinical | ECE2016

Decreased skin capacitance and elasticity may be reversible after treatment of Cushing’s syndrome

Karaca Zuleyha , Tarik Firat Sedat , Borlu Murat , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Background: Acne, stria and decreased skin elasticity are dermatological features of Cushing’s syndrome (CS). Although it is known that collagen mass in skin is decreased in CS and glucocorticoids play a role in acneiform skin lesions, the dermatological findings of CS has not previously been measured by reliable methods.Objective: The aim of the present study was to measure skin elasticity, capacitance, sebum content, pH and temperature in CS befor...

ea0037ep729 | Pituitary: clinical | ECE2015

Does cigarette smoking affect serum total cortisol and salivary cortisol levels?

Elbuken Gulsah , Karaca Zuleyha , Tanriverdi Fatih , Unluhizarci Kursad , Simsek Yasin , Kelestimur Fahrettin

Aim: Although there are some studies regarding the effects of cigarette smoking on serum total cortisol (STC) and salivary cortisol (SaC) levels, the results are still challenging. For this purpose, we aimed to determine the effects of cigarette smoking on STC and/ or SaC levels in a small group of healthy volunteers.Study design: 15 (five female and ten male) cigarette smoker with the mean age of 39.47±14.27, and 15 age and gender matched non-smoke...