Searchable abstracts of presentations at key conferences in endocrinology

ea0046nets1 | What's new in NETs? ENETS guidelines update (new recommendations applied to interactive cases), UK epidemiology and genetics | UKINETS2016

(Guidelines) update on small bowel NETs

Khan Mohid

With the ENETS guidelines update, there are a number of key issues tackled with this common subtype of NET. Terminology is clarified. Whether one uses neuroendocrine tumour, or neoplasm, as mentioned in the guidelines, the terms ‘midgut’ or ‘hindgut’ are thought not to be as helpful as indicating the primary anatomical site e.g. jejuno-ileal, rectal, colonic, caecal, appendiceal, etc.Grading with Ki-67 proliferation index, assessed fr...

ea0060nets4 | Diagnostic and Management Challenges in NETs | UKINETS2018

Duodenal NETs: under (-over) treated?

Khan Mohid

Duodenal neuroendocrine neoplasms (d-NENs) account for approximately 2% of all NENs, frequently encountered incidentally at endoscopy. They can be classified in a number of ways: ampullary/peri-ampullary and non-ampullary; gastrinomas, somatostatinomas, non-functional d-NENs, duodenal gangliocytic paragangliomas and high-grade poorly differentiated NECs. More than 90% arise in the 2st or 2nd part of the duodenum. ENETS guidelines suggest managing d-NENs according to size, with...

ea0080p2 | Abstracts | UKINETS2021

Vitamin deficiencies in patients with neuroendocrine tumours

Sivananthan Mathoorika , Khan Mohid , Dowd Charlotte

Background: Neuroendocrine tumours (NETs) are a heterogenous group of slow growing tumours with an increasing incidence. Disease-related diarrhoea, surgery and medical treatment can lead to malabsorption, resulting in vitamin deficiencies.Objective: To establish the prevalence of vitamin deficiencies in patients with NETs.Method: Retrospective review of NET patients seen since 2014 in South Wales across 6 health boards. Deficiencie...

ea0052p09 | (1) | UKINETS2017

Audit of South Wales Neuroendocrine MDT pathology reports

Peaker James , Morgan Meleri , Rees Aled , Khan Mohid , Christian Adam

The South Wales regional NET Multidisciplinary Meeting (MDT) discusses patients on a monthly basis. The European Neuroendocrine Tumour Society (ENETS) have guidance on expected pathology input into a NET MDT service. We assessed pathology reports submitted and discussed in 2016 for compliance with ENETS criteria, and determined the time from pathology reporting to MDT discussion. 117 patients had pathology submitted for review in 2016 and were assessed by one specialist NET pa...

ea0052p34 | (1) | UKINETS2017

Grading systems in gastroenteropancreatic neuroendocrine tumours

Hobby Charlotte , Morgan Meleri , Rees Aled , Khan Mohid , Christian Adam

Objective: To compare 3 methods of generating Ki-67% in gastroenteropancreatic neuroendocrine tumours (GEP-NETs).Methods: Twenty-four slides were used to generate 49 images for analysis. Each image was analysed and 3 different methods were used to calculate Ki-67%.Results: The comparison of Ki-67% from counting and estimating using the diameter (shortcut method) was strongly positively correlated, whereas the Ki-67% from counting a...

ea0052p06 | (1) | UKINETS2017

Nutritional assessment and vitamin deficiencies in patients with NETs

Lim Sheryl , Reynolds Mark , Chaudhry Rayhan , Blackhouse Jennifer , Rees Aled , Khan Mohid

Introduction: Neuroendocrine tumours (NETs) have diverse natural history and clinical syndromes. As a result of the disease or related to management, patients may have altered gut or pancreatic function that can cause nutritional deficiencies. There is a lack of consistent evidence-based dietetic guidance for patients with NETs.Aim: This study evaluated whether nutritional status and nutritional deficiencies had been assessed in patients with NETs in an ...

ea0068oc1 | Abstracts | UKINETS2019

Longitudinal biomarker changes during treatment of functional midgut neuroendocrine tumours with lanreotide autogel: CALM-NET study results

Shah Tahir , Caplin Martyn , Khan Mohid S , Houchard Aude , Higgs Kate , Meyer Tim

Background: CALM-NET (EudraCT 2013-002194-22; NCT02075606), a prospective, exploratory study, evaluated enumeration of pre-treatment circulating tumour cells as a predictor of symptomatic response to lanreotide autogel (LAN) in patients with functional midgut neuroendocrine tumours (NETs). Here, we describe the effect of LAN on biomarkers.Methods: Patients, ≥18 years, with functional, well- or moderately-differentiated midgut NETs were treated with...

ea0063p446 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Prevalence of non-carcinoid syndrome (non-CS) diarrhoea in patients with neuroendocrine tumours (NETs): a systematic literature review (SLR)

Khan Mohid S , Walter Thomas , Buchanan-Hughes Amy , Keeber Lucie , Feuilly Marion , Grande Enrique

Background: Approximately 20% of NET patients develop CS, characterised by diarrhoea and flushing. However, CS is not the only cause of diarrhoea among NET patients. Non-CS causes should be considered to allow for appropriate management. We investigated the reported occurrence of diarrhoea from various non-CS causes in patients with gastroenteropancreatic NETs (GEP-NETs), to explore the need for differential diagnosis (DDx) of NET diarrhoea.Methods: MEDL...

ea0046p23 | (1) | UKINETS2016

Evaluation of faecal elastase 1 in symptomatic patients with neuroendocrine tumours

Chaudhry Rayhan , Newbould Rachel , Williams Megan , Reid Kieran , Donnelly Lauren , Lewis Janet , Khan Mohid

Monitoring patients with NETs reveals a significant prevalence of gastrointestinal symptoms, often unrelated directly to the tumour1. Exocrine pancreatic insufficiency exemplifies a common treatable cause of gastrointestinal symptoms in NET patients undergoing therapy with somatostatin analogues. There is a paucity of data regarding this important issue which affects quality of life in NETs. We explored the value of faecal elastase (FE) as a marker of exocrine pancr...

ea0072p8 | (1) | UKINETS2020

The prevalence of depression and anxiety among neuroendocrine tumour and general gastroenterology outpatients and the psychometric validity of emotional thermometers

Linton Kirsty , Newton Hannah , Harris Sophie , Lancastle Deborah , John Bev , Vick Tracey , Rees Janice , Hewett Rhys , Khan Mohid , Tahor Tayyeb

Background: Depression and anxiety are frequently associated with functional gastrointestinal disorders (FGID), inducing personal suffering and a decreased quality of life. There is limited data in patients with NETs. Therefore, adequate research identifying the prevalence of these mood disorders among GI patients and NETs are necessary to inform holistic clinical management. Further, due to the nature of hospital clinics being fast-paced, quick and effective screening tools a...