Searchable abstracts of presentations at key conferences in endocrinology

ea0029p113 | Adrenal cortex | ICEECE2012

Usefulness of FDG–PET for detecting primary aldosteronism in patient who have bilateral adrenal incidentaloma

Kim Y. , Ko M. , Park C. , Nam-Goong I. , Na Y. , Kim E.

Adrenal masses are common incidental radiological findings. It has been estimated that as many as 10–20% of patients with essential hypertension may suffer from undiagnosed primary aldosteronism (PA). In patients who have both adrenal incidentaloma, which the functioning one must be identified. We report a case where an unilateral PA was detected on 18F-fluorodexoyglucose (FDG)-positron emission tomography (PET), and comfirmed by adrenal venous sampling.<p ...

ea0026p503 | Bone/calcium/Vitamin D | ECE2011

Differential gene expression in Runx2 and osterix double heterozygotes during skeletal development

Baek J E , Kim Y H , Baek W Y , de Crombrugghe B , Choi J Y , Kim J E

The transcription factors Runx2 and osterix (Osx), which are known as downstream genes in BMP2 pathway, are essential for osteoblast differentiation and bone formation. Runx2 expression is normal in Osx null mice, but Osx is not expressed in Runx2 null mice, indicating that Osx acts as a downstream of Runx2. Here, we questioned whether or not all bones could be formed by BMP2–Runx2–Osx pathway or unknown their own gene axis. To answer this question, we first analyzed...

ea0029p737 | Diabetes | ICEECE2012

The effect of nighttime glargine with morning NPH in type 2 DM.

Kim Y. , Shin D.

Recently basal insulin is the first recommended step when failed with oral medication, and adding morning NPH is one of step 1 intensive insulin treatment regimen when failed with basal insulin alone and post-lunch glucose level is high. But morning NPH or premixed insulin alone was the usual first step before basal insulin was available. When once a day morning insulin failed to reach target, next option was splitting twice a day injection. But many patients don’t agree ...

ea0007s21 | Neural migration in neuroendocrine systems | BES2004

GnRH neuronal Ontogeny - lessons from the investigation of Kallmann's Syndrome

Bouloux P , Hu Y , Kim S , Martinez|#Gonzalez D

The defining features of Kallmann's syndrome (KS) are isolated hypogonadotrophic hypogonadism (IHH) and anosmia, the consequences of a GnRH neuronal migratory defect and olfactory bulb agenesis respectively. Additional features in X-linked Kallmann's syndrome (XKI), include unilateral renal agenesis and bimanual synkinesis respectively. XKI results from mutations of KALIG 1, on Xp22.3. The encoded protein anosmin-1, is a hexamodular secreted cell membrane associated extracellu...

ea0029p1226 | Obesity | ICEECE2012

Curcumin inhibits the upregulation of cathepsin L by palmitate in fat

Yoo J. , Lee Y. , Kim J. , Kang S. , Nam J. , Park J. , Ahn C. , Song Y. , Kim K.

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

ea0041ep1138 | Thyroid cancer | ECE2016

The prevalence of thyroid malignancy incidentally detected by ultrasound in patients with non-thyroidal head and neck cancer

Joo Yun E , Young Yoon D , Jung Kim Y , Won Oh K

Thyroid cancer is one of the common head and neck malignancies and may be found incidentally with other head and neck cancers. The purpose is to evaluate the prevalence and risk of malignancy in incidental thyroid lesions identified by ultrasound (US) in patients with head and neck cancer. We retrospectively reviewed medical records of all patients with head and neck cancer other than of thyroid origin between January 2004 and January 2012. A total of 697 patients (542 men and...

ea0029p157 | Bone &amp; Osteoporosis | ICEECE2012

The level of Osterix expression in osteoblasts is important to prevent IL6-induced inflammatory-prone state

Baek W. , Kim Y. , Park S. , Kwon T. , Park K. , Kim J.

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...

ea0029p932 | Female Reproduction | ICEECE2012

Metabolic characteristics in women with polycystic ovary syndrome by phenotypes based on various diagnostic criteria

Sung Y. , Kim D. , Baik S. , Won K. , Kim H. , Oh J. , Lee H.

The metabolic features of Polycystic ovary syndrome (PCOS) can vary based on the definition used. The aim of this study is to compare the metabolic characteristics of PCOS according to the phenotypes from various diagnostic criteria and help to establish a optimal diagnostic criteria.Subjects with PCOS defined by the NIH criteria (n=494) and the Rotterdam criteria (n=568) and regular cycling non-hirsuite control women (n=1000) were r...

ea0011p240 | Cytokines and growth factors | ECE2006

Anosmin-1: a novel cofactor for fibroblast growth factor receptor 1

Hu Y , Kim S , Cadman S , Guimond S , Turnbull J , Bouloux P

Introduction: Autosomal dominant Kallmann’s syndrome (AKS) results from mutations within the fibroblast growth factor receptor 1 (FGFR1: KAL-2). The FGFR family of tyrosine kinases are involved in a multitude of biological processes from embryogenesis to adult homeostasis. The crystal structure of FGF-FGFR-heparan sulphate (HS) ternary complex has provided a basis for understanding the way in which FGF, FGFR and HS cooperate to assist FGFR dimerization. Anosmin-1, KAL-1 g...