Searchable abstracts of presentations at key conferences in endocrinology

ea0016p285 | Endocrine tumours | ECE2008

The role of parathyroid hormone-related protein on gynecomatia in patients with Klinefelter's syndrome and idiopathic gynecomastia

Deniz Ferhat , Bolu Erol , Azal Omer , Ozata Metin , Kutlu Mustafa

Background: Parathyroid hormone-related protein (PTHrP) was discovered as a tumor product. It is also one of the complex epithelial and mesenchymal interaction signal mediator in breast development. An increase in the prevalence of malignancy in patients with Klinefelter’s syndrome, but not in patients with idiopathic gynecomastia has been previously reported. PTHrP may play a critical role in the development or progression of breast cancer.Aim: We ...

ea0022p148 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Searching for the metabolic syndrome criteria in young adults with hypogonadism

Sonmez Alper , Haymana Cem , Bolu Erol , Tapan Serkan , Barcin Cem , Aydogdu Aydogan , Taslipinar Abdullah , Kutlu Mustafa

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

ea0022p162 | Cardiovascular endocrinology and lipid metabolism | ECE2010

The effect of testesterone replacement therapy on HDL subfraction levels in hypogonadotropic hypogonadism

Taslipinar Abdullah , Sonmez Y Alper , Bolu Erol , Tapan Serkan , Uckaya Gokhan , Aydogdu Aydogan , Kutlu Mustafa

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

ea0022p277 | Diabetes | ECE2010

Comparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patients

Ozsari Levent , Karadurmus Nuri , Sahin Mustafa , Uckaya Gokhan , Ural Ali Ugur , Musabak Ugur , Kutlu Mustafa

Objective: Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance.Methods: We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated fr...

ea0022p320 | Diabetes | ECE2010

Calcaneal spur incidence is increased in patients with type 2 diabetes mellitus

Aydogdu Aydogan , Akbulut Halil , Uckaya Gokhan , Taslipinar Abdullah , Sonmez Y Alper , Aydogan Umit , Kutlu Mustafa

Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to originate from chronic plantar fasciitis. But histological findings support the thesis that ‘plantar fasciitis’ is a degenerative fasciosis without inflammation. Diabetes mellitus may contribute to the risk of CS by decreased ability of tissue repair and increased reactive ossification. Thus, we aimed to determine CS incidence in asymptomatic obese subjects with and without type 2 diabete...

ea0020p408 | Diabetes and Cardiovascular | ECE2009

Effects of alteration in serum testosterone levels on beta cell functions in male patients with hypogonadism and in female patients with polycystic ovary syndrome

Uckaya Gokhan , Bolu S Erol , Ozgurtas Taner , Erbil M Kemal , Kutlu Mustafa

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

ea0022p697 | Obesity | ECE2010

Waist circumference does not reflect body fat distribution and insulin resistance in young male patients with idiopathic hypogonadotrophic hypogonadism

Aydogdu Aydogan , Kucukerdonmez Ozge , Uckaya Gokhan , Taslipinar Abdullah , Bolu S Erol , Sonmez Y Alper , Aydogan Umit , Kutlu Mustafa

Hypogonadism is associated with increased body fat content and insulin resistance. Many associations including ADA, IDF and EASD declare that waist circumference is a reliable measure of visceral adiposity and may account for insulin resistance. Our observations in young male patients with idiopathic hypogonadotrophic hypogonadism (IHH) are opposite. Thus, we aimed to compare body fat content and anthropometric measurements between patients and age-matched eugonadal healthy co...

ea0020p240 | Bone/Calcium | ECE2009

The effect of short term human chorionic gonadotropin treatment on the improvement of bone mass in patients with hypogonadotropic hypogonadism

Bolu Erol , Sonmez Alper , Apikoglu Mehmet , Gurel Hasan , Emer Ozdes , Taslipinar Abdullah , Ozguven M Ali , Kutlu Mustafa

Background: Idiopatic hypogonadotropic hypogonadism is a congenital abnormality due to GnRH deficiency which is associated with severe osteoporosis. Testosterone replacement has been shown to improve the loss in the bone mass. The aim of the present retrospective analysis was to measure the effect of human chorionic gonadotropin treatment on the improvement of bone mineral density.Methods: A total number of 96 young male (mean age 21±3.7 years) pati...

ea0020p367 | Diabetes and Cardiovascular | ECE2009

The relationship between hemoglobin levels and endothelial functions in diabetes mellitus

Sonmez Alper , Yilmaz M Ilker , Zoccali Carmine , Saglam Mutlu , Kilic Selim , Uckaya Gokhan , Eyileten Tayfun , Yenicesu Mujdat , Kutlu Mustafa

Introduction: Hemoglobin (Hb) is the main carrier and buffer of Nitric oxide. Recently, an inverse association between Hb and the endothelium dependent relaxation was observed in patients with Type 2 diabetes. Testing whether this association exists also in diabetic nephropathy is important because anemia in these patients starts at an earlier stage than in other renal disease. Also, at population level diabetes and renal dysfunction, particularly albuminuria, contribute indep...

ea0020p391 | Diabetes and Cardiovascular | ECE2009

Visfatin seems not to be related in insulin resistance

Taslipinar Abdullah , Taslipinar Mine Y , Azal Omer , Kebapcilar Levent , Sahin Mustafa , Uckaya Gokhan , Sonmez Y Alper , Kucukerdonmez Ozge , Kutlu Mustafa

Visfatin is a newly discovered adipocyte hormone. Recent studies showed a possible relationship between diabetes mellitus and visfatin level. But the effect of visfatin on the insulin resistance was not well understood. The aim of the present study was to explore the relation of visfatin with insulin resistance in patients with prediabetes and diabetes.We included a total of 128 persons in the study and of these 128 persons, 36 were diabetic, 69 were pre...