Endocrine Abstracts

Objective: Decline in the number of D2 receptor (D2R) is considered as the reason of resistance to dopamine agonists (DA). PP4R2 gene was observed up-regulated in prolactinoma patients according to our previous genechip study. In this study, we demonstrated that PP4C was crucial for D2R expression and PRL secretion in rat pituitary MMQ cells.Methods: In this study, we used rat pituitary MMQ cells which could secrete abundant prolactin and express functio...

BackgroundGraves’ Disease (GD) is characterized by production of stimulating autoantibodies to thyrotropin receptor resulting in hyperthyroidism. Hyperthyroidism is associated with insulin resistance, hyperglycemia and ketosis. Our aim was to evaluate if single nucleotide polymorphism (SNP) in pro-inflammatory cytokines contributes to dysglycemia in GD.MethodsWe evaluated 98 patients with Graves’ di...

Introduction: Immobilization induced hypercalcemia, which was first described in 1941 by Albright, is an uncommon reason for hypercalcemia. It is associated with increased bone remodeling disorders and conditions associated with limited movement such as medullar lesions or vascular events. The exact mechanism of the disorder is unknown. Diagnosis requires an detailed evaluation to rule out other causes of hypercalcemia.Case presentation: A 24 year old ma...

Context: Distinct differences of clinical manifestations exist in hypertensive pheochromocytomas (HPs) and normotensive phaeochromocytomas (NPs), however the comparative analysis is lacking.Objective: The objective of the study was to assess the clinical symptoms, haemodynamics, metabolism, radiological and histological features of patients with HPs and NPs.Research design and methods: This retrospective study included 104 patients...

Introduction: Primary retroperitoneal bronchogenic cysts are rarely seen. Bronchogenic cysts are mostly benign which originate from the remnants of the primitive foregut during the embryonic development.These lesions can be seen near or inside any organ that originates from the embryonic foregut. Bronchogenic cysts are most often found in the thoracic cavity, especially in the mediastinum. Except this many distant sites, such as abdomen, retroperitoneum,...

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormon...

Introduction: Persistent or intractable PHPT can lead to neuromuscular and psychiatric symptoms and may increase the long-term risk for cardiovascular disease and fractures. Cinacalcet (Mimpara/Sensipar) represents an innovative treatment option for this small group of patients, as it directly acts on the calcium sensing receptors on cell surfaces, reducing the severity of hypercalcemia.Purpose: To estimate the UK budget impact of cinacalcet in patients ...

IntroductionGestational diabetes mellitus (GDM) may frequently be overcome by nutrition therapy alone, but insulin regimen may be necessary in about 30 % of the patients with GDM. It was known that thyroid hormones were associated with glucose metabolism. Therefore, we aimed to investigate the association of fT4 level with insulin requirement in euthyroid pregnant women with GDM.Materials and methodsWe consec...

Osteoporosis is a progressive disease characterized by excessive bone loss which is often accompanied by augments in marrow adiposity as a result of estrogen deficiency, metabolic abnormalities or medications. Nuclear receptor estrogen-related receptor alpha (ESRRA) has a demonstrated role in energy homeostasis and fat metabolism. To determine if ESRRA is a potential therapeutic target for regulating fat-bone balance, we generated an adipocyte-specific ESRRA knockout mice (ESR...

Background: Liraglutide is a long-acting GLP-1 receptor (GLP-1R) agonist. GLP-1R is highly expressed in C-cells hyperplasia and in medullary thyroid cancer. We aimed to evaluate calcitonin levels stimulated by calcium test and possible development of C-cell hyperplasia during Liraglutide therapy in a case with obesity.Case Report: A 50-year-old woman was referred to endocrinology policlinic with complaints of increased appetite and weight gain. There wer...