Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep998 | Pituitary - Clinical | ECE2017

Ipilimumab-induced hypophysitis

Selfa Silvia Maria Maraver , Vega Maria Molina , Molero Inmaculada Gonzalez , Doblas Isabel Mancha , Madueno Francisco Tinahones

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

ea0035p210 | Clinical case reports Pituitary/Adrenal | ECE2014

Diabetes insipidus and hypopituitarism in a patient with idiopathic pulmonary fibrosis

Selfa Silvia Maraver , Garach Araceli Munoz , Cesar Maria Jose Picon , Doblas Isabel Mancha , Madueno Francisco Tinahones

Diabetes insipidus is a disease characterized by the inability to concentrate urine. The common form is central diabetes insipidus (CDI) caused by a lack of AVP after destruction of supraoptic–paraventricular nuclei. Further investigations are needed to establish its cause.: Case reportA 38-year-old woman presented with prompt polyuria–polydipsia. She has been taking contraceptive tablets for 2 years, smoked four to five cigarettes per day....

ea0022p708 | Obesity | ECE2010

Prevalence of no insulin-resistance in morbidly obese patients

Fernandez-Garcia Diego , Manuel Garcia Almeida Jose , Sebastian-Ochoa Arantzazu , Madueno Francisco Tinahones

Progression of metabolic syndrome to diabetes is not easily predicted in patients with morbid obesity. We hypothesized that no insulin-resistance is more usual as we thought.Objective: Evaluate prevalence of no insulin-resistance status in patients with morbid obesity.Patients and method: The study was undertaken in 130 patients with a BMI of 53.93±6.67 kg/m2. The morbidly obese patients were divided into four group...

ea0035p839 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Thyrotropinoma: one tumour, two different clinical presentations

Gomez Perez Ana Maria , Selfa Silvia Maraver , Vega Maria Molina , Pareja Isabel Cornejo , Garach Araceli Munoz , Madueno Francisco Tinahones

Thyrotropin-secreting pituitary tumors are <1% of pituitary adenomas. Clinical manifestations are similar to other forms of hyperthyroidism. Most of them are diagnosed as macroadenoma (microadenomas <10%).Case 1: A 48 years old woman with menopause presented 6 years ago, consulting in 2009 for weight loss and palpitations. She had elastic goiter and distal tremor. Blood test: TSH 8.66 μUI/ml (0.2–4.2), FT4 4.7 ng/dl (0.7&#150...

ea0056p25 | Adrenal cortex (to include Cushing's) | ECE2018

Presence of comorbidities related to hypercortisolism in a case series on adrenal incidentaloma (AI)

Cesar Maria Jose Picon , Vega Maria Molina , Garcia Carmen Hernandez , Perdigones Cristina Diaz , Fuentes Miguel Damas , Madueno Francisco Tinahones

Introduction: The European Society of Endocrinology Clinical Practice Guideline defines follow-up recommendations for AI based on the 1 mg overnight dexamethasone suppression test and the presence of associated comorbidities. Follow-up is not recommended for AI presenting serum cortisol levels post dexamethasone ≤1.8 μg/dl neither those presenting serum cortisol levels post dexamethasone between 1.9–5 μg/dl (defined as ‘possible autonomous cortisol se...

ea0056p894 | Clinical case reports - Thyroid/Others | ECE2018

Postmenopausal virilization with negative imaging

Vega Maria Molina , Doblas Isabel Mancha , Pareja Isabel Cornejo , Garach Araceli Munoz , Selfa Silvia Maraver , Madueno Francisco Tinahones

Introduction: After menopause, an abrupt drop in estrogen levels happens, while ovary androgens secretion declines gradually with aging. This relative hyperandrogenism may lead to the development of hyperandrogenic symptoms. However, the development of marked hirsutism and/or symptoms/signs of virilization, make necessary a detailed study in order to rule out tumorous cause (from adrenal glands or ovaries).Case report: 58 years old woman with progressive...

ea0037ep718 | Pituitary: clinical | ECE2015

Pituitary adenoma of aggressive behaviour

Selfa Silvia Maraver , Perez Ana Gomez , Doblas Isabel Mancha , Pareja Isabel Maria Cornejo , Vega Maria Molina , Perdigones Cristina Diaz , Madueno Francisco Tinahones

Pituitary ACTH-secreting tumour presents with variety of clinical features: normal cortisol secretion and ACTH-immunopositive staining and mild hypercortisolism without typical features of Cushing’s disease. We present a 53-year-old male with history of hypertension. First visit (2005): visual loss, bitemporal hemianopsia in campimetry and in MRI pituitary adenoma (2.5 cm) invading cavernous sinus and suprasellar cister. Hormonal study supported panhypopituitarism. After ...

ea0037ep1169 | Clinical Cases–Pituitary/Adrenal | ECE2015

Oncocytic adrenal cortical adenoma presenting as Cushing's syndrome: an exceptional clinical entity

Vega Maria Molina , Garach Araceli Munoz , Selfa Silvia Maraver , Perez Ana Gomez , Pareja Isabel Cornejo , Perdigones Cristina Diaz , Doblas Isabel Mancha , Madueno Francisco Tinahones

Introduction: Oncocytomas are tumours composed by oncocytes, cells with granular and eosinophilic cytoplasm filled with mitochondria. It is a neoplasm that can arise in several organs (more commonly described in the kidney, salivary gland and thyroid). Oncocytoma arising in the adrenal gland is a rare finding. Most of them are benign and non-functioning and are detected incidentally. However, functional adrenal oncocytomas presenting as Cushing’s syndrome and phaeochromoc...

ea0037ep1207 | Clinical Cases–Pituitary/Adrenal | ECE2015

Cushing's syndrome secondary to aberrant hormone receptors in a patient with macronodular adrenal hyperplasia ACTH-independent

Vega Maria Molina , Medina Jose Antonio Lopez , Garach Araceli Munoz , Pareja Isabel Cornejo , Perdigones Cristina Diaz , Perez Ana Gomez , Madueno Francisco Tinahones

Introduction: Cushing’s syndrome (CS) due to macronodular adrenal hyperplasia ACTH-independent (MAHAI) is rare. Regulation of cortisol secretion by G-protein-coupled receptors (GPCRs) aberrantly expressed is frequently found in MAHAI. Various aberrant receptors have been reported, mostly: GIP, vasopressin, beta-adrenergic, LH/hCG and serotonin.Case report: 61 years old woman. Medical history: type 2 diabetes, hypertension, obesity, dyslipidaemia and...

ea0056p299 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

PCSK9 inhibitors as an add on for the treatment of dislipemia in real clinical practice

Garcia Carmen Hernandez , Perdigones Cristina Maria Diaz , Fuentes Miguel Damas , Martinez Clara Estaun , Ramos Andrea Sanchez , Ramos Ana Molina , Madueno Francisco Tinahones

Introduction and objectives: The treatment with monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) is a new group of drugs that allows us to reach the therapeutic targets of low density cholesterol (LDL-c) in patients intolerant to statins or those who despite treatment with maximum doses of them do not obtain a proper lipid control.Material and methods: We performed a descriptive observational study. We include all ...