Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc11.2 | Oral Communications 11: Thyroid 2 | ECE2022

What you choose makes the difference: the first medical therapy for amiodarone-induced thyrotoxicosis has significant implications on cardiovascular events and hospitalizations

Cappellani Daniele , Cosentino Giada , Morganti Riccardo , Manetti Luca , Bartalena Luigi , Bogazzi Fausto

Context: Amiodarone is a widely used anti-arrhythmic medication, however associated with a 15-20% rate of thyroid adverse effects. Amiodarone-induced thyrotoxicosis (AIT) is a complex disease due to diagnostic difficulties and therapeutic challenges. AIT patients often receive initial therapy for thyrotoxicosis before admission to a referral center. Whether the first-line medical therapy (i.e. therapies for thyrotoxicosis at first diagnosis of AIT) may affect the outcome of AI...

ea0037ep1219 | Clinical Cases–Pituitary/Adrenal | ECE2015

Autoimmune hypophysitis: from pituitary expansion to empty sella: description of four cases

Marconcini Giulia , Lupi Isabella , Manetti Luca , Cosottini Mirco , Urbani Claudio , Martino Enio , Marcocci Claudio , Bogazzi Fausto

Four patients with autoimmune hypophysitis were followed since the diagnosis of the disease. All presented with severe headache, decreased libido, astenia. Case 1 and 3 presented polyuria and polydipsia. At MRI pituitary was enlarged, with high gadolinum uptake and stalk enlargement.Case 1, male 41 years. MRI volume: AP 13 mm, CC 7 mm. Hormonal assessment: central hypothyroidism, hypoadrenalism, hypogonadism, normal GH and IGF1, hyperprolactinemia, centr...

ea0022p5 | Adrenal | ECE2010

Evaluation of haemostatic and fibrinolytic markers in patients with Cushing's syndrome: a longitudinal study

Raffaelli Valentina , Manetti Luca , Ruocco Lucia , Giovannetti Clara , Genovesi Maura , Pellegrini Giovanni , Bogazzi Fausto , Martino Enio

Patients with active Cushing’s syndrome (CS) have an increased coagulability and thrombotic tendency. High glucocorticoids concentrations increase plasma clotting factors, especially von Willebrand factor (vWf) and reduced fibrinolytic capacity. Thromboemobolic complications, mainly in the postsurgical phase, have been reported.Aim of this longitudinal study was to evaluate haemostatic and fibrinolytic markers in patients with active Cushing’s ...

ea0022p564 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Use of cabergolin in Nelson's syndrome: preliminary results in four patients

Giovannetti Clara , Manetti Luca , Raffaelli Valentina , Cosottini Mirco , Genovesi Maura , Martino Enio

The Nelson’s syndrome (NS) is characterized by hyperpigmentation, sellar growing mass, and increased plasma ACTH concentrations The management of NS remains difficult: neurosurgery represent the first choice therapy. Many drugs have been used with variable results: cyproeptadine, GABA-agonists, somatostatin analogues, chemiotherapy, PPAR-γ-agonists, and dopamin-agonists.Aim of this study was to evaluate the efficacy of cabergoline administratio...

ea0022p613 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Tumor infiltrating lymphocytes but not serum pituitary antibodies are associated with poor clinical outcome after surgery in patients with pituitary adenoma

Lupi Isabella , Manetti Luca , Caturegli Patrizio , Menicagli Michele , Bevilacqua Genersoso , Bogazzi Fausto , Martino Enio

Serum pituitary antibodies (Pit Abs) and tumor infiltrating lymphocytes (TILs) have been described in a small percentage of pituitary adenomas but their clinical significance remains unknown.Aim of the study was to assess Pit Abs and TILs prevalence in patients with pituitary adenomas and to determine their influence on the clinical outcome. In this prevalence case–control study were enrolled 291 pituitary adenoma cases, (110 non-secreting, 30 ACTH-...

ea0014p572 | (1) | ECE2007

Impairment of GH secretion by ghrelin stimulation test in primary hyperparathyroidism (PHP)

Cecconi Elisabetta , Giovannetti Clara , Manetti Luca , Raffaelli Valentina , Procopio Massimo , Ghigo Ezio , Gasperi Maurizio , Martino Enio

Pituitary GH secretion is regulated by the interplay of at least two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin, through their interaction with specific cell surface receptors on the anterior pituitary somatotrophs. A third type of receptor, the growth hormone secretagogue receptor, called GHS receptor type 1a (GHSR1a), was identified in the pituitary and the hypothalamus. Ghrelin is an acylated peptide produced predominantly by stomach and a natural l...

ea0056p835 | Pituitary - Clinical | ECE2018

IgG4-related neuroinfundibulo-hypophysitis treated by rituximab and corticosteroids

Lupi Isabella , Urbani Claudio , Manetti Luca , Cosottini Mirco , Brancatella Alessandro , Cappellani Daniele , Bogazzi Fausto

IgG4-related hypophysitis, a type of IgG4-related disease, is a rare condition. It appears to be sensitive to glucocorticoids in most patients, but its recurrence is likely.Clinical case: A 17 year-old girl was referred for hypotonic polyuria and polydipsia of 1 month duration. Water deprivation test was suggestive of central diabetes insipidus. Basal and dynamic assessment of pituitary anterior function were unremarkable. Patient did suffer from autoimm...

ea0099p102 | Pituitary and Neuroendocrinology | ECE2024

Establishing BMI-Related thresholds for the 1 mg dexamethasone suppression test: a retrospective analysis

Urbani Claudio , Corleo Davide , Venturi Caterina , Marconcini Giulia , Bogazzi Fausto , Lupi Isabella , Santini Ferruccio , Manetti Luca

Background: Cushing Syndrome (CS) is associated with metabolic disturbances, including obesity. The 1 mg Dexamethasone Suppression Test (1mgDST) is widely used to assess cortisol regulation in suspected CS patients. However, its interpretation may require adjustments based on individual factors, such as body mass index (BMI), due to obesity’s influence on cortisol metabolism. The literature offers differing cutoff values for obese patients. This study aimed to establish B...

ea0081ep774 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s syndrome due to adrenocorticotropic hormone-secreting metastatic neuroendocrine pancreatic tumor: diagnostic workup and management

Cosentino Giada , Manetti Luca , Marconcini Giulia , Boggi Ugo , Marconcini Riccardo , Lupi Isabella , Cappellani Daniele , Urbani Claudio , Bogazzi Fausto

We report the clinical history of a 21-years old young female who, in February 2021, presented abdominal pain and biliary vomiting that lasted for two months. An esophagus-gastroduodenoscopy revealed a duodenal ulcerative lesion and proton pump inhibitory therapy was started with clinical benefit. One month later, the patient presented a facial acneiform rush with hirsutism for which she was referred to our attention. An abdominal MRI documented a well-circumscribed hyper-vasc...

ea0070aep917 | Thyroid | ECE2020

Total thyroidectomy for amiodarone-induced thyrotoxicosis: Identification of the surgical candidates and preparation to surgery

Cappellani Daniele , Papini Piermarco , Maria Di Certo Agostino , Mantuano Michele , Manetti Luca , Materazzi Gabriele , Bartalena Luigi , Bogazzi Fausto

Background: Amiodarone-induced thyrotoxicosis (AIT) is a challenging disease associated with increased morbidity and mortality. The European Thyroid Association guidelines define the role for total thyroidectomy in the management of AIT. However, these recommendations were based on small series, which often lead to heterogeneous results and, importantly, did not identify patients who may benefit from surgery.Materials and methods: Observational longitudi...