Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc2.1 | Thyroid | ECE2010

Calcitonin screening and pentagastrin testing: predictive value for diagnosis medullary carcinoma in nodular thyroid disease

Herrmann Burkhard , Schmid Kurt , Bockisch Andreas , Kemen Mathias , Mann Klaus

Context: Serum calcitonin (hCT) measurement may be useful for detecting medullary carcinoma (MTC), but the routine use of hCT and after pentagastrin stimulation to screen patients with nodular thyroid disease remains controversial.Patients: One thousand and seven patients (667 females, 440 males) with nodular thyroid disease and a mean age of 55±14 (mean±S.D.) years were included in the study. All patients did not have impaired r...

ea0020p31 | Adrenal | ECE2009

Confounding variables for plasma metanephrines and normetanephrines may influence the diagnosis of pheochromocytomas

Deutschbein Timo , Jager Andrea , Mann Klaus , Petersenn Stephan

Introduction: Measurements of plasma metanephrines (META) and normetanephrines (NOR) have been advocated as first-line tests for the diagnosis of pheochromocytoma. This study assessed the impact of several potential confounders, which may influence the correct diagnosis.Methods: Eight healthy males (age 26.8±1.7; BMI 23.1±0.8) were tested on 6 separate days. Tests were performed in supine rest with blood sampling via i.v. canullas at 0900 h fol...

ea0016p304 | Endocrine tumours | ECE2008

Inhibition of intracellular signaling pathways and induction of cell cycle arrest by the multi-kinase inhibitor sorafenib in thyroid carcinoma cells

Broecker-Preuss Martina , Redmann Anja , Britten Martin , Mann Klaus

Objective: Therapeutic options for patients with dedifferentiated thyroid carcinoma are rare and alternative treatment strategies are needed. Among the most promising new agents for these patients are protein kinase inhibitors like the BRAF- and multi-targeted kinase inhibitor sorafenib. We have already shown that sorafenib inhibits growth of dedifferentiated thyroid carcinoma cell lines with and without BRAF mutation. The purpose of this study was to analyze the molecular eff...

ea0016p595 | Paediatric endocrinology | ECE2008

Day profiles of salivary 17-hydroxyprogesterone for the control of glucocorticoid therapy in adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Deutschbein Timo , Unger Nicole , Hauffa Berthold , Mann Klaus , Petersenn Stephan

Introduction: Optimizing glucocorticoid (GC) therapy in patients with congenital adrenal hyperplasia (CAH) remains a challenge. While overdosing may result in Cushing’s syndrome, underdosing is associated with female virilization and adrenal insufficiency. This study evaluated day-profiling of salivary 17-hydroxyprogesterone (17OHP) for the biochemical control of adolescents with CAH due to 21-hydroxylase deficiency.Methods: Twelve patients (4 males...

ea0014p565 | (1) | ECE2007

The effects of pasireotide (SOM230) on glucose metabolism and growth hormone (GH) nadir during oral glucose tolerance test (OGTT) in 12 patients with acromegaly from a Phase II study

Petersenn Stephan , Glusman Joan , Unger Nicole , Mann Klaus

Introduction: Pasireotide (SOM230) is a novel multi-ligand somatostatin analogue with high binding affinity for four of the five somatostatin receptor subtypes (sst1,2,3 and sst5). A randomized study of 59 patients showed that pasireotide effectively controls GH and IGF-I levels in patients with acromegaly and reduces pituitary tumor size. The impact of pasireotide on GH levels during glucose suppression and glucose metabolism in 12 patients enrolled in t...

ea0022p55 | Adrenal | ECE2010

Influence of various clinical variables and storage conditions on urinary cortisol levels: gas chromatography–mass spectrometry (GC–MS) versus immunoassay

Deutschbein Timo , Broecker-Preuss Martina , Hartmann Michaela , Wudy Stefan , Althoff Ricarda , Mann Klaus , Petersenn Stephan

Introduction: Measurement of urinary cortisol is often used to assess disease activity in patients with suspected or proven hypercortisolism. However, specific reference ranges are lacking for some of the newer assays. This study analyzed upper limits of normal (ULN, mean+2S.D.) for two analytical procedures (GC–MS, ECLIA) in relation to various independent variables. Besides, the influence of different storage conditions was investigated (by ECLIA).<p ...

ea0022p396 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Outcome of two chemotherapies in the treatment of progressive, undifferentiated neuroendocrine carcinomas: a single-center experience

Deutschbein Timo , Unger Nicole , Yuece Ali , Lahner Harald , Mann Klaus , Petersenn Stephan

Introduction: Treatment of poorly differentiated neuroendocrine tumors (NET) usually includes chemotherapeutic intervention. However, both the rarity and the heterogeneity of the disease have led to relatively few clinical trials. This study evaluated the outcome of two chemotherapy regimens in patients suffering from undifferentiated and histologically confirmed NET.Methods: Eighteen patients (11 males; age 56.7±2.5) with proven progressive disease...

ea0022p503 | Growth factors | ECE2010

Acromegaly: a prospective analysis of the oral and maxillofacial pathologies and its impact of disease duration

Herrmann Burkhard , Mortsch Florentine , Berg Christian , Weischer Thomas , Mohr Christopher , Mann Klaus

Context: It is well established that clinical features of acromegaly concern the teeth and the jaw, but less is known about the degree of oral and maxillofacial pathologies and its impact of the disease duration.Patients: Twenty-eight acromegalics (13 females, 15 males) with a mean age 49±11 (mean±S.D.) years (range 31–70) were included in the study. Thirty-two percent had active disease, 39% were well-controlled under the s...

ea0020p24 | Adrenal | ECE2009

Characterization of tyrosine hydroxylase expression in various adrenal tumors to confirm the diagnosis of adrenal pheochromocytomas

Ueberberg Bianca , Hinrichs Jakob , Walz Martin K , Schmid Kurt W , Mann Klaus , Petersenn Stephan

Background: Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis catalyzing the conversion of tyrosine to dihydroxyphenylalanine (DOPA). To establish a molecular marker for adrenal pheochromocytomas, we compared the expression in various adrenal tumors in comparison to normal adrenal glands.Methods: Tissue from 19 pheochromocytomas (PHEO), 20 aldosterone-producing adenomas (APA), 20 cortisol-producing adenomas (CPA), an...

ea0016p476 | Neuroendocrinology | ECE2008

Prospective comparison of the glucagon stimulation test (GST) with the insulin tolerance test (ITT) in patients following pituitary surgery

Berg Christian , Meinel Timo , Yuece Ali , Lahner Harald , Mann Klaus , Petersenn Stephan

Objective: The ITT is the gold-standard for assessment of GH and ACTH reserve but has certain contraindications. GH and cortisol responses of <3 ng/ml and <500 nmol/l, respectively, have been defined as evidence of severe deficiency. The GST like the ITT stimulates both the ACTH and GH secretion and is suggested to be a good alternative in terms of efficiacy. However, there are limited prospective data with modern assays on sensitivity and specificity for the GST in co...