Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc8.3 | Rapid Communications 8: Calcium and Bone | ECE2023

CYP24A1 mutation as a rare cause of hypercalcemia during pregnancy

Kullamaa Liisa , SOderlund Sanni , Viukari Marianna , Matikainen Niina , Schalin-Jantti Camilla

Clinical case: A 27-year-old pregnant woman (24 weeks of gestation) was investigated as her Hb level (87 g/l) was low. Laboratory work-up revealed severe, non-PTH dependent hypercalcemia (see Table). This was her first pregnancy, and serum calcium measured once previously 12 years earlier had been normal. The patient had symptoms of increased thirst, constipation and hyperemesis.Diagnostic work up and Treatment: Rehydration and close mon...

ea0090p566 | Adrenal and Cardiovascular Endocrinology | ECE2023

Evaluation of CYP11B2 immunostaining findings and cure rates of primary aldosteronism subtyped by anatomical imaging and functional methods

Viukari Marianna , Leijon Helena , Vesterinen Tiina , Porsti Ilkka , Nevalainen Pasi I. , Matikainen Niina

Background: The best lateralization method to ascertain cure after surgery in unilateral primary aldosteronism (PA) is debated. Risk of persistent of PA in those with non-classical adrenal histopathology remains poorly characterized.Objective: We examined the value of anatomical compared with functional subtyping and the significance of immunohistochemical analysis of CYP11B1 and CYP11B2 for the outcome and histopathological diagnosis of primary aldoster...

ea0063gp195 | Adrenal and Neuroendocrine - Clinical | ECE2019

Evaluation of clinical and biochemical cure and adrenal CYP11B2 and CYP11B1 immunostaining in primary aldosteronism operated after adrenal venous sampling

Matikainen Niina , Nevalainen Pasi I , Soinio Minna , Gomez-Sanchez Celso , Vesterinen Tiina , Leijon Helena

Background: The cure of unilateral primary aldosteronism (PA) after adrenalectomy can result in complete, partial or absent biochemical and clinical improvement1. Histological findings from HE samples are of little assistance in determining if adenoma or hyperplastic adrenal tissue is hormonally overactive. Our aim in the present study was to compare immunohistochemical (IHC) CYP11B1 and CYP11B2 staining in adrenal slices to histological diagnosis based on H&E s...

ea0056p131 | Endocrine tumours and neoplasia | ECE2018

Severe impairments in health-related quality of life in patients with small intestine neuroendocrine tumors

Matikainen Niina , Karppinen Noora , Linden Riikka , Sintonen Harri , Tarkkanen Maija , Roine Risto , Heiskanen Ilkka , Schalin-Jantti Camilla

Background: The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow, treatment options and long-term survival rates have improved. Health-related quality of life (HRQoL) is considered an important measure of patients’ perception of the burden of their disease and the impact of treatment modalities. Despite this, data on whether improvements in treatment options and survival rates also translate into improved HRQoL...

ea0099ep257 | Endocrine-Related Cancer | ECE2024

The value of cumulative serum 5-HIAA exposure in diagnostics of carcinoid heart disease: A prospective follow up in patients with small intestinal neuroendocrine tumors

Kostiainen Iiro , Simonen Piia , Aaltonen Katri , Linden Riikka , Karppinen Noora , Gordin Daniel , Rapola Janne , Schalin-Jantti Camilla , Matikainen Niina

Introduction: In small intestinal neuroendocrine tumors (SI-NET), unphysiological exposure to serotonin is considered as a major pathogenic factor predisposing to the development carcinoid heart disease (CHD), a complication of carcinoid syndrome associated with poor prognosis. The ability of biomarkers to predict the development of CHD is limited. The aim of our prospective study was to assess risk factors of CHD development and mortality in SI-NET.Meth...

ea0090p384 | Endocrine-related Cancer | ECE2023

Impact of SSTR PET/CT imaging on the follow-up of pancreatic NET in MEN1

Kostiainen Iiro , Majala Susanna , Schildt Jukka , Parviainen Helka , Kauhanen Saila , Seppanen Hanna , Miettinen Paivi , Matikainen Niina , Ryhanen Eeva , Schalin-Jantti Camilla

Introduction: In multiple endocrine neoplasia 1 (MEN1), the decreased life expectancy is related especially to pancreatic neuroendocrine tumors (panNETs). Timely diagnosis of potentially aggressive panNETs is the cornerstone of the follow-up in MEN1. Somatostatin receptor positron emission tomography (SSTR PET/CT) has a high accuracy in the detection of neuroendocrine tumors. The role of this imaging modality in early diagnosis and follow-up of MEN1-related panNETs is unclear....

ea0073pep9.5 | Presented ePosters 9: Endocrine-Related Cancer | ECE2021

Endothelial and vascular function, biomarkers and clinical presentation in patients with small intestine NETs

Kostiainen Iiro , Rosengård-Bärlund Milla , Karppinen Noora , Simonen Piia , Rapola Janne , Lindén Riikka , Schalin-Jäntti Camilla , Matikainen Niina

Background20–30% of patients with metastatic small intestine neuroendocrine tumours (SI-NETs) suffer from carcinoid syndrome (CS), i.e. diarrhea, flushing, and bronchospasm. Of these, 25–50% develop carcinoid heart disease (CHD) characterized by valve fibrosis and right heart failure. There are no early predictive markers of CHD, which typically is diagnosed in the advanced stage.Aims of the studyTo...

ea0073aep792 | Late Breaking | ECE2021

Long-term follow-up in primary aldosteronism: the major determinant of the haemodynamic phenotype is volume load

Kokko Eeva , Mutanen Aapo , Choudhary Manoj , Tikkakoski Antti , Onni Niemelä , Viukari Marianna , Matikainen Niina , Mustonen Jukka , Nevalainen Pasi , Ilkka Pörsti

BackgroundAldosterone excess causes volume retention and cardiovascular damage. We evaluated the long-term haemodynamic changes in patients with targeted treatment of primary aldosteronism (PA) (n = 40) in comparison with essential hypertension (EH) (n = 40) and untreated normotensive controls (n = 40).MethodsPA patients were subjected to adrenal vein sampling and allocated to adren...