Endocrine Abstracts

Objective: To determine effectiveness of supplementing vitamin D alone vs vitamin D+ calcium on bone mass accrual in underprivileged Indian premenarcheal girls.Methods: A double blind, matched pair, cluster randomization study was carried out in 200 premenarcheal girls (8–12 years) from three public schools. The participants were randomized into two clusters and were allocated to receive either vitamin D (Group A): 30 000 IU oral cholecalciferol eve...

Objectives: Type one diabetes mellitus (T1DM) is associated with various autoimmune conditions including celiac disease. Both these conditions are independently and variably associated with risk of osteoporosis. The current study intended to study bone health parameters and factors affecting it in patients with T1DM with serological evidence of celiac disease (CD).Methods: A cross sectional study including 100 type one diabetes patients following up in o...

Objective: The aim of the present study was to assess the association between vitamin D receptor (VDR) gene polymorphism and bone mass indices in Indian adolescent girls.Methods: The current study was a cross sectional one including 100 post menarcheal girls aged 15–18 years. Serum levels of ionized calcium, inorganic phosphorus, alkaline phosphatase, parathyroid hormone and 25 hydroxy vitamin D were measured. Bone mineral content (BMC), Bone area (...

Objectives: The current study intended to assess the impact of GH deficiency (GHD) on bone health after using various size corrections.Methods: Thirty prepubescent children with GHD (male:female=20:10, mean age −9.4±3.5 years) were included in the study. Data on anthropometry and total body bone mineral content (TBBMC), bone area (TBBA) and lean body mass (TBLBM) by dual energy X-ray absorptiometry were collected. Anthropometric Z-sco...

Objective: To assess the prevalence of multiple endocrine neoplasia type 1 (MEN1) in patients with symptomatic primary hyperparathyroidism (PHPT).Methods: A retrospective analysis of 75 consecutive patients with symptomatic PHPT from January 1994 to July 2012 was done, who underwent parathyroid surgery at our centre. Five patients had MEN1 syndrome. Among them 1 was familial MEN1. The patients with MEN1 were analyzed based on clinical presentation, bioch...

Objective: To know the prevalence of primary hyperparathyroidism (PHPT) in urolithiasis and predictors of PHPT in urolithiasis.Methods: This cross sectional study was conducted between July 2005 and July 2012 in department of endocrinology and urology at our hospital. In this study a total of 165 consecutive patients with urolithiasis with radioopaque stones were evaluated for clinical and biochemical profile. Stones retrieved were analyzed for type of s...

Objective: i) To evaluate plasma levels of IL6, adiponectin and resistin in subjects with diabetic foot in comparison with subjects without foot complications. ii) To assess the impact of vitamin D status on the levels of above inflammatory markers.Methods: A total 100 diabetic foot cases and 100 diabetic controls were recruited in the study. Serum level of 25OH vitamin D was estimated from the cases and controls by RIA. Serum IL6, adiponectin and resist...

Objective: To present a patient with long standing type 2 diabetes complaining of chronic pelvic pain, due to an uncommon cause of bilateral vas calcification.Methods: Clinical, laboratory and radiographic data are reported on a 62-year-old diabetic presenting with chronic pelvic painResults: A 62-year-old man with a history of 17 years of diabetes presented with chronic dull aching, non radiating pain in the pelvis and in the regi...

Objective: Laparoscopic ileal interposition (II) with sleeve gastrectomy (SG)/diverted sleeve gastrectomy (DSG) are types of modified bariatric surgery for treatment of type 2 diabetes (T2DM). DSG is preferred over SG in patients with less favourable metabolic profile. Owing to variable remission response in our patients, retrospectively we devised a novel score metabolic surgery assessment score (MSAS). It helps to select the type of procedure and to predict the diabetes remi...

Objectives: i) To determine and compare inflammatory markers including adiponectin, visfatin and IL-18 in patients with polycystic ovarian syndrome (PCOS). ii) To find out whether adiponectin and interleukin-18 (IL-18) is associated with markers of insulin resistance, hyperandrogenism and carotid intima-media wall thickness (CIMT) as a cardiovascular risk factor.Methods: This is a prospective controlled study involving 60 consecutive euglycemic patients ...